DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15436 and ZNF256

DIOPT Version :9

Sequence 1:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_005764.2	Gene:	ZNF256 / 10172	HGNCID:	13049	Length:	627	Species:	Homo sapiens

Alignment Length:	340	Identity:	110/340 - (32%)
Similarity:	159/340 - (46%)	Gaps:	61/340 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YEDVKSAYGIRQTCEESHQFYCRVRDEGIEDALCALLEEEDWEISEDEDARIDSASAAD------ 114
            :..||:.|...:..:.....:.||:.:|      .|:.|..:..||...:...|.|.:|
Human   204 FHSVKNHYNWGECVKAFSYKHVRVQHQG------DLIRERSYMCSECGKSFSTSCSLSDHLRVHT 262

  Fly   115 --------DDGKSDSKKVAF-------------ECRECHKKYQRKGTFLRHMRTHMDGQSFPCPY 158
                    :.|||..:..:.             :|.||.|.:.||...|.|.|.|...:.:.|..
Human   263 SEKPYTCGECGKSYRQSSSLITHRRIHTGVRPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCSE 327

  Fly   159 CKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSS 223
            |.::|....:|..|.:.|...:|||||.|.|:|...|:|.:|:|.|||.||:.||:|.|:|.:|.
Human   328 CGKSFSHSSSLITHQRIHTGMRPYECSECGKSFIHSSSLITHQRVHTGTRPYMCSECGKSFSQSC 392

  Fly   224 DLRRHIRTHGSERPFKCSKCTKTFT----------------------------RKFHLDNHFRSH 260
            .|.:|.|.|..|.|::||:|.|.||                            |||.|..|.|.|
Human   393 HLIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVRSHECHECGKLFSRKFDLIVHERVH 457

  Fly   261 TGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCP 325
            |||||::||.|.|:|..|.:|..|.::|...||:.|..|.|:|..||||.:|:.||..||.::|.
Human   458 TGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECN 522

  Fly   326 HCASFYKQRKTLARH 340
            .|..|:.|..:|.||
Human   523 ECGKFFSQSSSLIRH 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	3/21 (14%)
		C2H2 Zn finger	128..148	CDD:275368	9/19 (47%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		COG5048	<180..341	CDD:227381	78/189 (41%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..219	CDD:290200	12/21 (57%)
		C2H2 Zn finger	212..232	CDD:275368	9/19 (47%)
		zf-H2C2_2	224..249	CDD:290200	12/52 (23%)
		C2H2 Zn finger	240..260	CDD:275368	12/47 (26%)
		zf-H2C2_2	252..276	CDD:290200	13/23 (57%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	7/17 (41%)
ZNF256	NP_005764.2	KRAB	14..54	CDD:366587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76
		C2H2 Zn finger	215..233	CDD:275368	3/23 (13%)
		C2H2 Zn finger	241..261	CDD:275368	5/19 (26%)
		C2H2 Zn finger	269..289	CDD:275368	3/19 (16%)
		COG5048	293..626	CDD:227381	94/245 (38%)
		C2H2 Zn finger	297..317	CDD:275368	9/19 (47%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
		C2H2 Zn finger	381..401	CDD:275368	9/19 (47%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		C2H2 Zn finger	493..513	CDD:275368	9/19 (47%)
		C2H2 Zn finger	521..541	CDD:275368	7/17 (41%)
		C2H2 Zn finger	549..569	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	605..625	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910