DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gs1l and PUDP

DIOPT Version :9

Sequence 1:	NP_477228.1	Gene:	Gs1l / 33653	FlyBaseID:	FBgn0019982	Length:	231	Species:	Drosophila melanogaster
Sequence 2:	NP_001129037.1	Gene:	PUDP / 8226	HGNCID:	16818	Length:	251	Species:	Homo sapiens

Alignment Length:	244	Identity:	117/244 - (47%)
Similarity:	153/244 - (62%)	Gaps:	24/244 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VTHCVFDMDGLLL-----------------------DTERLYTVATEMILEPYGKTYPFEIKEQV 50
            |||.:||||||||                       ||||||:|..:.|...|.|.|.:::|..|
Human     8 VTHLIFDMDGLLLGYTGSIVAAASGESSRGLQSRWTDTERLYSVVFQEICNRYDKKYSWDVKSLV 72

  Fly    51 MGLQTEPLARFMVEHYELPMSWEEYARQQRANTEILMRNAQLMPGAERLLRHLHANKVPFCLATS 115
            ||.:....|:.:::..:||||.||...:.:...:.:...|.||||||:|:.||..:.:||.||||
Human    73 MGKKALEAAQIIIDVLQLPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHGIPFALATS 137

  Fly   116 SGADMVELKTAQHRELFSLFNHKVCGSSDKEVVNGKPAPDIFLVAAGRFGVPPKPSDCLVFEDSP 180
            ||:...::||::|:|.||||:|.|.| .|.||.:|||.|||||..|.||..||....||||||:|
Human   138 SGSASFDMKTSRHKEFFSLFSHIVLG-DDPEVQHGKPDPDIFLACAKRFSPPPAMEKCLVFEDAP 201

  Fly   181 NGVTAANSAGMQVVMVPDPRLSQEKTSHATQVLASLADFKPEQFGLPAF 229
            |||.||.:||||||||||..||::.|:.||.||.||.||:||.||||::
Human   202 NGVEAALAAGMQVVMVPDGNLSRDLTTKATLVLNSLQDFQPELFGLPSY 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gs1l	NP_477228.1	YcjU	12..220	CDD:223710	107/230 (47%)
Gs1l	NP_477228.1	HAD_like	16..231	CDD:304363	112/237 (47%)
PUDP	NP_001129037.1	PGMB-YQAB-SF	11..217	CDD:213673	93/206 (45%)
PUDP	NP_001129037.1	HAD_like	15..251	CDD:304363	112/237 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159400
Domainoid	1	1.000	185	1.000	Domainoid score	I3400
eggNOG	1	0.900	-	-		E1_COG0637
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8093
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3476
Isobase	1	0.950	-	0	Normalized mean entropy	S1244
OMA	1	1.010	-	-		QHG57193
OrthoDB	1	1.010	-	-		D1510544at2759
OrthoFinder	1	1.000	-	-		FOG0001355
OrthoInspector	1	1.000	-	-		oto89604
orthoMCL	1	0.900	-	-		OOG6_100310
Panther	1	1.100	-	-	LDO	PTHR18901
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1909
SonicParanoid	1	1.000	-	-		X845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750