DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Secp43 and TIAL1

DIOPT Version :9

Sequence 1:	NP_608837.2	Gene:	Secp43 / 33652	FlyBaseID:	FBgn0031607	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001029097.1	Gene:	TIAL1 / 7073	HGNCID:	11804	Length:	392	Species:	Homo sapiens

Alignment Length:	373	Identity:	97/373 - (26%)
Similarity:	138/373 - (36%)	Gaps:	100/373 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LWMGSLESYMTENFIIAAFRKMG---------EDPTTVRLMRNKYTG---------EPAGYCFVN 54
            |::|:|...:||..|:..|.::|         |.|.:.|:  |...|         :|  ||||.
Human    11 LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRV--NSSVGFSVLQHTSNDP--YCFVE 71

  Fly    55 FISDDHALDAMHKLNGKPIPGTNPIVRFRLNSASNSYKLPGNEREFSVWVGDLSSDVDDYQLYKV 119
            |.....|..|:..:||:.|.|....|.:....:|..   ......|.|:|||||.::....:...
Human    72 FYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQK---KDTSNHFHVFVGDLSPEITTEDIKSA 133

  Fly   120 FSSKFTSIKTAKVILD-SLGFSKGYGFVRFGIEDEQKSALYDMNGYIGLGTKPIKICNAV---PK 180
            | :.|..|..|:|:.| :.|.|||||||.|..:.:.::|:..|.|. .||.:.|:...|.   |.
Human   134 F-APFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQ-WLGGRQIRTNWATRKPPA 196

  Fly   181 PKSELGGAVGEGNT---------------NYGYGSGMTAAGGTD--YSQYYDPTSTYWQ------ 222
            |||     ..|.||               |.....|..|:|.||  ..|.:.|.....:
Human   197 PKS-----TQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE 256

  Fly   223 -GYQAWQ-GYYEQAGASIT---------------------DAAAYYQQA-------MSQSHSNPQ 257
             ||...: ..:|.|..:|.                     |....:||.       .||.:.|||
Human   257 KGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQ 321

  Fly   258 TLAQH-AEAWSAQRSAQYEQQQQQ------QTASAA----NGAEDENG 294
            ...|: |..|.......|.|...|      |:.|||    .||:...|
Human   322 QYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Secp43	NP_608837.2	RRM1_SECp43	7..90	CDD:241054	27/99 (27%)
Secp43	NP_608837.2	RRM2_SECp43	99..180	CDD:241056	29/84 (35%)
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	27/99 (27%)
		RRM2_TIAR	113..192	CDD:410029	29/80 (36%)
		RRM3_TIAR	222..294	CDD:241064	12/71 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1842
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940