DRSC/TRiP Functional Genomics Resources

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Protein Alignment Secp43 and TIA1

DIOPT Version :10

Sequence 1:NP_608837.2 Gene:Secp43 / 33652 FlyBaseID:FBgn0031607 Length:336 Species:Drosophila melanogaster
Sequence 2:NP_071505.2 Gene:TIA1 / 7072 HGNCID:11802 Length:386 Species:Homo sapiens


Alignment Length:396 Identity:93/396 - (23%)
Similarity:134/396 - (33%) Gaps:144/396 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LWMGSLESYMTENFIIAAFRKMGEDPTTVRLMRNKYTGEPAG---YCFVNFISDDHALDAMHKLN 69
            |::|:|...:||..|:..|.::|.......:|      :.||   ||||.|....||..|:..:|
Human     9 LYVGNLSRDVTEALILQLFSQIGPCKNCKMIM------DTAGNDPYCFVEFHEHRHAAAALAAMN 67

  Fly    70 GKPIPG--------TNPIVRFRLNSASNSYKLPGNEREFSVWVGDLSSDVDDYQLYKVFSSKFTS 126
            |:.|.|        |.|..:.:..|:|.......::..|.|:|||||.::....:...| :.|..
Human    68 GRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAF-APFGR 131

  Fly   127 IKTAKVILD-SLGFSKGYGFVRFGIEDEQKSALYDMNGYIGLGTKPIKICNAV---PKPKSELGG 187
            |..|:|:.| :.|.|||||||.|..:.:.::|:..|.|. .||.:.|:...|.   |.|||..  
Human   132 ISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQ-WLGGRQIRTNWATRKPPAPKSTY-- 193

  Fly   188 AVGEGNTNY--------------------GYGSGMT----------------------------- 203
               |.||..                    |..||:|                             
Human   194 ---ESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVR 255

  Fly   204 ------------AAGGTDYSQYYDPTSTYW--------------------QGYQAWQGYY---EQ 233
                        :..||....:.  ...||                    |.|..|..:|   :|
Human   256 FNSHESAAHAIVSVNGTTIEGHV--VKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQ 318

  Fly   234 AGASITD-----AAAYYQQAMSQSHSNPQTLAQHAEAW----------------------SAQRS 271
            .|..:.:     |...|.||.:|...| ||  |.:..|                      |..|.
Human   319 IGQYMPNGWQVPAYGMYGQAWNQQGFN-QT--QSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRV 380

  Fly   272 AQYEQQ 277
            |.||.|
Human   381 AGYETQ 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Secp43NP_608837.2 RRM1_SECp43 7..90 CDD:410022 27/92 (29%)
RRM2_SECp43_like 99..178 CDD:409781 28/79 (35%)
Trnau1ap 210..330 CDD:465438 24/118 (20%)
TIA1NP_071505.2 RRM1_TIA1 8..81 CDD:410027 23/77 (30%)
RRM2_TIA1 104..181 CDD:410030 28/78 (36%)
RRM3_TIAR 214..286 CDD:241064 8/73 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386 5/31 (16%)

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