DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Secp43 and Pspc1

DIOPT Version :9

Sequence 1:	NP_608837.2	Gene:	Secp43 / 33652	FlyBaseID:	FBgn0031607	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001020843.1	Gene:	Pspc1 / 305910	RGDID:	1310122	Length:	522	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	75/341 - (21%)
Similarity:	130/341 - (38%)	Gaps:	80/341 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CQLWMGSLESYMTENFIIAAFRKMGEDPTTVRLMRNKYTGEPAGYCFVNFISDDHALDAMHKLNG 70
            |:|::|:|.:.:||......|.:.|| |:.|.:.|::      |:.|:...|...|..|..:|:|
  Rat    81 CRLFVGNLPTDITEEDFKRLFERYGE-PSEVFINRDR------GFGFIRLESRTLAEIAKAELDG 138

  Fly    71 KPIPGTNPIVRFRLNSASNSYKLPGNEREFSVWVGDLSSDVDDYQLYKVFSSKFTSIKTAKVILD 135
            ..:......:||..:.|:.:.|             :||..|.:..|.:.| |:|..::.|.|::|
  Rat   139 TILKSRPLRIRFATHGAALTVK-------------NLSPVVSNELLEQAF-SQFGPVEKAVVVVD 189

  Fly   136 SLGFSKGYGFVRFGIEDEQKSALYDM-NGYIGLGTKPIKICNAVPKPKSELGGAVGEGNTNYGYG 199
            ..|.:.|.|||.|..:...:.||... :|...|.|.|..:   :.:|
  Rat   190 DRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPV---IVEP------------------ 233

  Fly   200 SGMTAAGGTDYSQYYDPTSTYWQGYQAWQGYYEQAGASITDAAAYYQQAMSQSHSNPQTLA-QHA 263
                      ..|:.|......:..|..|.|::             ::......:.|.|.. ::|
  Rat   234 ----------MEQFDDEDGLPEKLMQKTQQYHK-------------EREQPPRFAQPGTFEFEYA 275

  Fly   264 EAWSAQRSAQYEQQQQQQT------ASAANGAEDENGLVEHKFVLDVDKLNREAIDADRRLYD-- 320
            ..|.|  ..:.|:||::|.      |.....||.|....||:.:|....|.|...:. |||.:
  Rat   276 SRWKA--LDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEEL-RRLEELR 337

  Fly   321 --ALESSKWLPIEQLE 334
              .|:..|.:.:...|
  Rat   338 NQELQKRKQIQLRHEE 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Secp43	NP_608837.2	RRM1_SECp43	7..90	CDD:241054	21/82 (26%)
Secp43	NP_608837.2	RRM2_SECp43	99..180	CDD:241056	22/81 (27%)
Pspc1	NP_001020843.1	RRM1_PSP1	80..150	CDD:241030	19/75 (25%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000250	124..357		61/291 (21%)
		RRM2_PSP1	156..235	CDD:241033	24/123 (20%)
		NOPS_PSPC1	226..319	CDD:240584	22/138 (16%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000250	230..357		30/168 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000