Protein Alignment CG15439 and PHF14

DIOPT Version :10

• Sequence 1: NP_608836.1
• Gene: CG15439 / 33651
• FlyBaseID: FBgn0031606
• Length: 1008
• Species: Drosophila melanogaster
• Sequence 2: NP_001007158.1
• Gene: PHF14 / 9678
• HGNCID: 22203
• Length: 948
• Species: Homo sapiens
• Alignment Length: 1045
• Identity: 314/1045 - (30%)
• Similarity: 437/1045 - (41%)
• Gaps: 351/1045 - (33%)

  Fly     9 ITTQALLDFDLGESSSDSDFLPDI---DNCSDGSKDESDGDGSSSDASGGSDSESDSDAESEDST 70
            ::.:.|.|.|..:|..|:|:.|.:   ...|...|:.|||| :..|...||.|:.|.:.|..|
Human   195 VSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGD-NEDDEDEGSGSDEDENDEGND-- 256

  Fly    71 LQLRQLLAETEPSPLENGINGVDHCAASSPAAPVVPR----------APLQLSSAPAKR------ 119
                    |...||...|       ......:.|:.|          ..|.||.:.:..
Human   257 --------EDHSSPASEG-------GCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILE 306

  Fly   120 --------------MCCVCLGERSDDVNEIVECDSCGVSVHEGCYGV-SDNVSISSTNSTCSTEP 169
                          :||||||:.|:|.:||::||:||::|||||||| .::.||.|:.|..||||
Human   307 KSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEP 371

  Fly   170 WFCEACRAGVSEPDCELCPNKGGIYKETDVGKWVHLICALYVPGVAFGEVEQLSSVTLFEMQYSK 234
            |||:||:.||| |.||||||:.||:||||.|:|||::|||||||||||::::|..|||.||.|||
Human   372 WFCDACKCGVS-PSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSK 435

  Fly   235 WGAKVCSLCENALFARTGVCIGCDAGMCKTYFHVTCAQVAGFLIEAHHEDDAADPFYAHCKVHSE 299
            :|||.||.||:..||||||||.||||||:.||||||||..|.|.||..|:|.||||:|:||.|::
Human   436 YGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHAD 500

  Fly   300 KEMIKKRRRNYHTLR--LNMMQRAREKEALAAEHETPAPHPNPAQARIQRKLLKIQHKYTRHKEL 362
            :...|.:|:||..|:  ..|..:.|||: |:.|          |||||..:|.:.:.|....:..
Human   501 RLDRKWKRKNYLALQSYCKMSLQEREKQ-LSPE----------AQARINARLQQYRAKAELARST 554

  Fly   363 KPTPWVPTQKMSRLLTTSASACRRLLAKAEIMSVDVQHLEQREAHINALTDIRKKWHIAPAFSVE 427
            :|..|||.:|:.|.||:||||.|:|:.|||:|.:.........:..::..|.|:| |..||.:.:
Human   555 RPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRK-HKQPALTAD 618

  Fly   428 FTAYYMDRIVRMDDFRQQQRELISHNAILSKDQDVLRAQYDTALEERKAVKATKDSLLTSIKSLH 492
            |..||.:|.:||...::...|..:....|..:|:.|..:|:...|..:.::.....|.:..:.:.
Human   619 FVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGIW 683

  Fly   493 TALGQI-APNMTLPSVDLIAHPLPEAPPKTSTPTPPQRPISVPTAAALKMGVGFPLGHLGPPGSK 556
            ..||:| ...:.:|::  :..|....|.|
Human   684 ALLGRITGQKLNIPAI--LRAPKERKPSK------------------------------------ 710

  Fly   557 MDSSRMLSTHAKQGKHSTSSASVEAAPSVSCGICKRSKDQHLLVKCDTCNLHYHLGCLNPPLTRP 621
                       |:|  .|...|...|...||||||::.|||||:.||||.||||||||:|||||.
Human   711 -----------KEG--GTQKTSTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRM 762

  Fly   622 PKKSKQYGWQCSECCDKSEGSDAVTEISSGPRKSRTRFNKDGHLVYVDRYSLDDIPVAAVNVPKE 686
            |:|:|...||||| ||::..||...::
Human   763 PRKTKNSYWQCSE-CDQAGSSDMEADM-------------------------------------- 788

  Fly   687 SHTKRALNKSLPAPAPEYIEDLTKSPKRPKLQSPCK-TPINVPAENVTPTTDAAPVAASAATPAA 750
                          |.|.:.|.||..:| :::.|.| .|.:||
Human   789 --------------AMETLPDGTKRSRR-QIKEPVKFVPQDVP---------------------- 816

  Fly   751 APTLPTPNTIVINLSGCEDSIDDSSGKLSRKGKRKDKHKNKHNLSSDTEKSIGKEHKRKRKKRAH 815
                |.|..|.|                                         :..:.:.:||:.
Human   817 ----PEPKKIPI-----------------------------------------RNTRTRGRKRSF 836

  Fly   816 LDESSTHLDNAGNTSGSTIKIIFKALRLPGEDAPESQYFYVPANAVRSVDEASRPTSVETVEDSV 880
            :.|...|
Human   837 VPEEEKH---------------------------------------------------------- 843

  Fly   881 QGAEQALAPIVLPAASPQKVREPKETAASASVNPTPSPKRKVSPRKASPRKPRVGRPRVSNAKPN 945
                              :.|.|:|                           |..|..|...||.
Human   844 ------------------EERVPRE---------------------------RRQRQSVLQKKPK 863

  Fly   946 VE---ISCCVCSQTGKSNQVVTCDECHRHYHFACLDPPLKKSPKIRGYSWHCADCDPT----DED 1003
            .|   ..|..|..||.:..:|.||||...|||.|||||||||||..||.|.|.:||.:    ||:
Human   864 AEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDEN 928

  Fly  1004 ALPKK 1008
            ...:|
Human   929 EAERK 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15439	NP_608836.1	PHD1_PHF14	120..175	CDD:277036	33/55 (60%)
		ePHD_PHF14	184..297	CDD:277144	78/112 (70%)
		PHD2_PHF14	586..635	CDD:277037	35/48 (73%)
		PRK10819	854..>938	CDD:236768	5/83 (6%)
		PHD3_PHF14	949..997	CDD:277038	27/47 (57%)
PHF14	NP_001007158.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..302		29/124 (23%)
		PHD1_PHF14	321..377	CDD:277036	33/55 (60%)
		ePHD_PHF14	385..498	CDD:277144	78/112 (70%)
		PHD2_PHF14	727..776	CDD:277037	36/49 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..862		17/220 (8%)
		PHD3_PHF14	870..918	CDD:277038	27/47 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	920..948		3/14 (21%)