DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS18 and Slc17a7

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_892038.2	Gene:	Slc17a7 / 72961	MGIID:	1920211	Length:	560	Species:	Mus musculus

Alignment Length:	455	Identity:	119/455 - (26%)
Similarity:	200/455 - (43%)	Gaps:	67/455 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RVWFITLITGT--CMLYSTRTTMPLLVPA--------------VASAQ-KWSKTDSGTVLSSFFW 74
            |.:.|.:::|.  |:.:..|..:.:.:.:              |..|| .|.....|.:..||||
Mouse    61 RRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFW 125

  Fly    75 GYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQ 139
            ||.:||:.||:...:|...||..||.:..|.:..|:|    :|..:....:.|   :|||.|.::
Mouse   126 GYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIP----SAARVHYGCVIF---VRILQGLVE 183

  Fly   140 GVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAW 204
            ||.:|:...:.|:...|.|||........||..|.::...:...|:.|.|||.||.|.|..||.|
Mouse   184 GVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFW 248

  Fly   205 A---LVLRYYAMA-----------------GERNRIINIATPSRLCANKSPAETSAVPWLRYFRR 249
            .   |::.|.:.|                 ||..:::|            |......||.|:|..
Mouse   249 YLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMN------------PVTKFNTPWRRFFTS 301

  Fly   250 LSFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL----PPCTLFAKYLT 308
            :..:|.::.:.|....|::||...|.||.:  ||..:|..:|:.:|.|.:    |.....|.:|.
Mouse   302 MPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLR 366

  Fly   309 TRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQD 373
            :|.:   ..||.|||::....|..:...|.|:..:.....|:..:.:.:|.:||..:...||..|
Mouse   367 SRHI---MSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLD 428

  Fly   374 LAPLHSGSVFGLMNTVGAIPGFLGVYLAGHIL--ELTQSWPMVFSAAAGINLVGWIIFIVFGSAE 436
            :||.::..:.|:.|.||.:.|.:...:.|.:.  :..:.|..||..|:.::..|.|.:.||.|.|
Mouse   429 IAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGE 493

Fly 437 436
Mouse 494 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	114/446 (26%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	106/407 (26%)
Slc17a7	NP_892038.2	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	114/445 (26%)
Slc17a7	NP_892038.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820