Protein Alignment MFS18 and SLC17A6

DIOPT Version :10

• Sequence 1: NP_608835.1
• Gene: MFS18 / 33650
• FlyBaseID: FBgn0025684
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_065079.1
• Gene: SLC17A6 / 57084
• HGNCID: 16703
• Length: 582
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 115/446 - (25%)
• Similarity: 200/446 - (44%)
• Gaps: 49/446 - (10%)

  Fly    27 RVWFITLITGT--CMLYSTRTTMPLLVPAVASAQ---------------KWSKTDSGTVLSSFFW 74
            |.:.|.:::|.  |:.:..|..:.:.:..:.:..               .|.....|.:..||||
Human    69 RRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFW 133

  Fly    75 GYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQ 139
            ||.:||:.|||.:.|....||...|.:..|.:..|:|    :|..:....:.|   :|||.|.::
Human   134 GYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIP----SAARVHYGCVIF---VRILQGLVE 191

  Fly   140 GVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAW 204
            ||.:|:...:.|:...|.|||........||..|.::...:...|:.|.|||.||.|.|..|:.|
Human   192 GVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVW 256

  Fly   205 A---LVLRYYAMA------GERNRII--NIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLT 258
            .   |::.|.:.|      .|..|.|  :|...:.|.......:|   ||.::|..:..:|.::.
Human   257 YMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKT---PWRKFFTSMPVYAIIVA 318

  Fly   259 HACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL----PPCTLFAKYLTTRLLAREWH 317
            :.|....|::||...|.||.:  ||..:|..:::.:|.|.:    |.....|.:|.::.:.   .
Human   319 NFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQIL---S 380

  Fly   318 TTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSV 382
            ||||||::....|..:...|.|:..:.....|:..:.:.:|.:||..:...||..|:||.::..:
Human   381 TTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 445

  Fly   383 FGLMNTVGAIPGFLGVYLAGHIL--ELTQSWPMVFSAAAGINLVGWIIFIVFGSAE 436
            .|:.|.||.:.|.:...:.|.:.  :..:.|..||..||.::..|.|.:.:|.|.|
Human   446 MGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS_SLC17A9_like	31..433	CDD:340938	111/437 (25%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	110/436 (25%)