DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS18 and slc17a8

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	450	Identity:	119/450 - (26%)
Similarity:	204/450 - (45%)	Gaps:	61/450 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 WFITLITGT--CMLYSTRTTMPLLVPAVAS--------------AQ-KWSKTDSGTVLSSFFWGY 76
            :.|.:::|.  |:.:..|..:.:.:..:.:              || .|.....|.:..||||||
Zfish    76 YIIAMLSGLGFCISFGIRCNLGVAIVEMVNNNTVYINGTAVMQPAQFNWDPETVGLIHGSFFWGY 140

  Fly    77 TLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQGV 141
            .:||:.||:.|::....||...|....|::...:|    :|..:....:.|   :|||.|.::||
Zfish   141 IVTQIPGGFISNKLAANRVFGAAIFLTSVLNMFIP----SAARVHYGCVMF---VRILQGLVEGV 198

  Fly   142 HFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWA- 205
            .:|:...:.|:...|.|||........||..|.::...:...|:.|.||..||.:.|:.||.|.
Zfish   199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYVGWPSVFYIYGVFGIIWYI 263

  Fly   206 --LVLRYYAMA-------GERNRI-INIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHA 260
              ::|.|.:.|       .|||.| .:|...:.|   .|..|....||..:|..:..:|.::.:.
Zfish   264 FWILLAYNSPAVHPTISEEERNYIETSIGEGANL---MSSTEKFKTPWREFFTSMPVYAIIVANF 325

  Fly   261 CEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLAL----PPCTLFAKYLTTRLLAREWHTT 319
            |....|::||...|.||.:  |||.:|..:::.:|.:.:    |.....|.:|.:|.:.   .||
Zfish   326 CRSWTFYLLLISQPAYFEEVFGFPISKVGILSAVPHMVMTIIVPIGGQLADFLRSRKIL---STT 387

  Fly   320 TVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVT---VNPQDLAPLHSGS 381
            ||||::....|..:...|.|:..:   ||..:.::.:|...||...|::   ||..|:||.::..
Zfish   388 TVRKIMNCGGFGMEATLLLVVGFS---HTRAVAISFLILAVGFSGFAISGFNVNHLDIAPRYASI 449

  Fly   382 VFGLMNTVGAIPGFLGVYLAGHILELTQ-----SWPMVFSAAAGINLVGWIIFIVFGSAE 436
            :.|:.|.||.:.|.:...:.|   .||:     .|..||..|:.::..|.|.:.:|.|.|
Zfish   450 LMGISNGVGTLSGMVCPLIVG---ALTKHKTRLEWQHVFVIASMVHYTGVIFYAIFASGE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	116/443 (26%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	106/401 (26%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	118/449 (26%)
		MFS	81..503	CDD:119392	115/440 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820