DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS18 and slc17a9b

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001002635.1	Gene:	slc17a9b / 436908	ZFINID:	ZDB-GENE-040718-380	Length:	465	Species:	Danio rerio

Alignment Length:	421	Identity:	169/421 - (40%)
Similarity:	244/421 - (57%)	Gaps:	14/421 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WTRHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGY 85
            |||...|:|.:.|:.|||:||..|..||:...::|....|||.::|.||.||||||..|||:|||
Zfish    42 WTRPVARIWTVVLLLGTCLLYCARVAMPICAVSMAERFSWSKRETGMVLGSFFWGYCFTQVLGGY 106

  Fly    86 FSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQGVHFPSMISLT 150
            .|||.||::|:|.:|..|..:|...|.:    ....|..|..:...|.|.|.|||||:||:.||.
Zfish   107 VSDRVGGEKVMLLSAAAWGAMTAFTPIL----AHFCSQPIFSMTLSRFLMGLLQGVHYPSLASLC 167

  Fly   151 SQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMAG 215
            ||.:..:||......:.:||.||||:.|.:||.:||.:||..||.|.||:.:.||..:..|.:.|
Zfish   168 SQKVVESERGFLMSTVGSGSYLGTLVIGGVGSLMLDLYGWESVFYVSGLLSVLWAYCMWKYLLKG 232

  Fly   216 ERNRIINIATPSRLCANKSPAETSAVP---WLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYF 277
            | ..||.:.:..      |....|.:|   |||.||:.:..|.::||.|..:.||.|||||||:|
Zfish   233 E-GPIITLESLG------SAGTQSKIPKRNWLRLFRQPAVCAVIITHLCTASTFFTLLSWLPTFF 290

  Fly   278 HDGFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSR 342
            .|.||.|||||.|:|||....|.:||:..|:..|:::.:.|.:|||::|.......::....:..
Zfish   291 KDTFPDAKGWVFNVIPWFVAIPSSLFSGCLSDHLISQGFDTASVRKLMQFFSMGVSSVFTLFLCG 355

  Fly   343 TSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILEL 407
            |:.|..|:..::..:|.|.|.::.|:||.|||||..:|::||:|||.||..|.:.||.:|:::|.
Zfish   356 TTTFPAAVAFVSATMGLTTFSHSGVSVNVQDLAPSCAGALFGVMNTCGAFTGVIMVYFSGYLIET 420

  Fly   408 TQSWPMVFSAAAGINLVGWIIFIVFGSAEAI 438
            |.||..||.....:||:|...|:.|..|..:
Zfish   421 TGSWASVFGLITVVNLLGLTTFLSFAEARRV 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	162/404 (40%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	149/367 (41%)
slc17a9b	NP_001002635.1	MFS	51..446	CDD:119392	162/405 (40%)
slc17a9b	NP_001002635.1	MFS_1	54..409	CDD:284993	149/365 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586868
Domainoid	1	1.000	283	1.000	Domainoid score	I1606
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76562
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2419
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D357187at33208
OrthoFinder	1	1.000	-	-		FOG0005560
OrthoInspector	1	1.000	-	-		otm25322
orthoMCL	1	0.900	-	-		OOG6_107359
Panther	1	1.100	-	-	LDO	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3559
SonicParanoid	1	1.000	-	-		X3977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800