DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS18 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	407	Identity:	107/407 - (26%)
Similarity:	192/407 - (47%)	Gaps:	57/407 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VWFITLITGTCMLYSTRT-------TMPLLVPAVASAQK--WSKTDSGTVLSSFFWGYTLTQVVG 83
            |..:.::.....|...||       :.|:.|....:.:|  |.....|.:|.|||:||.:||:.|
Human    62 VALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPG 126

  Fly    84 GYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQGVHFPSMIS 148
            ||.:.:.||:.::.|..:|.:::|...|.       .....:..::.:|.|.|..:||.||:|.:
Human   127 GYVASKIGGKMLLGFGILGTAVLTLFTPI-------AADLGVGPLIVLRALEGLGEGVTFPAMHA 184

  Fly   149 LTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALV------ 207
            :.|....|.|||....:..||:.|||:::..:...:..|..|:|||...|.:||.|.|:
Human   185 MWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVS 249

  Fly   208 --------LRYYAMAGERNRIINIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMN 264
                    :.:|    |:..|:: :..::|.:.||      |||:...:.|..||.|:.|.....
Human   250 DTPQKHKRISHY----EKEYILS-SLRNQLSSQKS------VPWVPILKSLPLWAIVVAHFSYNW 303

  Fly   265 CFFVLLSWLPTYFHD--GFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTT--VRKVI 325
            .|:.||:.||||..:  .|...:...::.:|:|....|.:.:......|.|: |:.:|  ||::
Human   304 TFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAK-WNFSTLCVRRI- 366

  Fly   326 QSCCFAAQNL---ALFVMSR---TSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSVFG 384
                |:...:   |:|:::.   ..|:..|:..:||.....||.::..::|..|:||.::|.:.|
Human   367 ----FSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLG 427

  Fly   385 LMNTVGAIPGFLGVYLA 401
            :.||...|||.:|..:|
Human   428 ITNTFATIPGMVGPVIA 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	106/405 (26%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	104/397 (26%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	107/407 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820