DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS18 and Slc17a5

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_766361.1	Gene:	Slc17a5 / 235504	MGIID:	1924105	Length:	495	Species:	Mus musculus

Alignment Length:	408	Identity:	115/408 - (28%)
Similarity:	192/408 - (47%)	Gaps:	58/408 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSY 123
            ||.....|.:|.|||:||.:||:.|||.:.|.||:.::....:|.|:.|...|.       ....
Mouse   102 KWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPL-------AADL 159

  Fly   124 AIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYF 188
            .:..:|.:|.|.|..:||.||:|.::.|....|.|||....:..||:.|||:::..:...:..|.
Mouse   160 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM 224

  Fly   189 GWSYVFRVIGLMGIAWALV--------------LRYYAMAGERNRIINIATPSRLCANKSPAETS 239
            .|:|||.:.|::||.|.::              :.:|    |:..|:: :..::|.:.|
Mouse   225 NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHY----EKEYIVS-SLKNQLSSQK------ 278

  Fly   240 AVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHD--GFPHAKGWVVNMIP----WLALP 298
            .|||....:.|..||.|:.|......|:.||:.||||..:  .|...:...::.:|    ||.:.
Mouse   279 VVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMI 343

  Fly   299 PCTLFAKYLTTRLLAREWH--TTTVRKVIQSCCFAAQNL---ALFVMSR---TSDFHTALICMTI 355
            .|...|.||..:     |:  |.:||::     |:...:   |:|:::.   ..|:..|:..:||
Mouse   344 LCGQAADYLRVK-----WNFSTISVRRI-----FSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTI 398

  Fly   356 IIGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHIL--ELTQSWPMVFSAA 418
            .....||.::..::|..|:||.::|.:.|:.||...|||..|..:|..:.  ...:.|..||..|
Mouse   399 STTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIA 463

  Fly   419 AGINLVGWIIFIVFGSAE 436
            |.||:.|.|.|.:|...|
Mouse   464 AAINVFGAIFFTLFAKGE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	113/402 (28%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	101/365 (28%)
Slc17a5	NP_766361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Dileucine internalization motif. /evidence=ECO:0000250	22..23
		2A0114euk	30..491	CDD:129972	115/408 (28%)
		MFS	99..478	CDD:119392	113/403 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820