DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS18 and Slc17a9

DIOPT Version :9

Sequence 1:	NP_608835.1	Gene:	MFS18 / 33650	FlyBaseID:	FBgn0025684	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_898984.3	Gene:	Slc17a9 / 228993	MGIID:	1919107	Length:	447	Species:	Mus musculus

Alignment Length:	424	Identity:	170/424 - (40%)
Similarity:	256/424 - (60%)	Gaps:	12/424 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DTQSIWTRHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQ 80
            ||:  |:|.|.:.|...|:.|||:||..|.|||:...|::....|:|.::|.|||||||||.|||
Mouse    26 DTR--WSRPECQAWTGILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQ 88

  Fly    81 VVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQGVHFPS 145
            ||||:..||.||::|||.:|..|..||...|.:    ..:.|..:.|:...|||.|.||||:||:
Mouse    89 VVGGHLGDRIGGEKVILLSASAWGFITVTTPLL----AHLGSGHLAFLTFSRILTGLLQGVYFPA 149

  Fly   146 MISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWA-LVLR 209
            :.||.||.:..:||:..:..:.|||.:|||:||.:||.|||..||..||...|.:.:.|| .|.|
Mouse   150 LTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYR 214

  Fly   210 YYAMAGERNRIINIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLP 274
            |  :..|::.::.:..   |.......:.|.|||.:.||:.|.||.:.:..|....||:||||||
Mouse   215 Y--LLNEKDLVLALGF---LAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLP 274

  Fly   275 TYFHDGFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFV 339
            |:|.:.||::||||.|::||:...|.:||:.:::.||:::.:...||||.:|.......::....
Mouse   275 TFFKETFPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALC 339

  Fly   340 MSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHI 404
            :..|:.|..|:|..:..||...|:::.::||.|||||..:|.:||:.||.||:.|.:||.|:|::
Mouse   340 LGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYL 404

  Fly   405 LELTQSWPMVFSAAAGINLVGWIIFIVFGSAEAI 438
            :|.|.||..||...|.|:.:|...|:|||.|:.:
Mouse   405 IETTGSWTCVFHLVAIISNLGLGTFLVFGKAQRV 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS18	NP_608835.1	MFS	30..432	CDD:119392	160/402 (40%)
MFS18	NP_608835.1	MFS_1	32..397	CDD:284993	146/365 (40%)
Slc17a9	NP_898984.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		170/424 (40%)
		MFS	40..432	CDD:119392	160/400 (40%)
		2A0114	43..424	CDD:273326	157/389 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842446
Domainoid	1	1.000	284	1.000	Domainoid score	I1622
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76562
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2476
Isobase	1	0.950	-	0	Normalized mean entropy	S4312
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005560
OrthoInspector	1	1.000	-	-		oto94780
orthoMCL	1	0.900	-	-		OOG6_107359
Panther	1	1.100	-	-	LDO	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3559
SonicParanoid	1	1.000	-	-		X3977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740