DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp3 and ELP3

DIOPT Version :9

Sequence 1:	NP_608834.1	Gene:	Elp3 / 33649	FlyBaseID:	FBgn0031604	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_015239.1	Gene:	ELP3 / 856019	SGDID:	S000006007	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	549	Identity:	404/549 - (73%)
Similarity:	467/549 - (85%)	Gaps:	7/549 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKLGVGLSRQERQVLVIGEIIQELLKA--HEAKKDVNLNRMKSLVASKYGLDSSPRLVDIIAAV 66
            ||||.   ..:||.:....:|..||..:  ....:::|||.:.:..:.||.|...|||.|||.::
Yeast    12 KKKLA---PEKERFIQCCADITLELTDSLTSGTTREINLNGLITKYSKKYKLKQQPRLTDIINSI 73

  Fly    67 PQDAKKILLPKLRAKPIRTASGIAVVAVMCKPHRCPHINMTGNICVYCPGGPDSDFEYSTQSYTG 131
            |...||.|||||:|||:|||||||||||||||||||||..|||||||||||||||||||||||||
Yeast    74 PDQYKKYLLPKLKAKPVRTASGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTG 138

  Fly   132 YEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLPEEYRDYFIRNLHDALS 196
            ||||||||||:||||:.|.|.|||||||||||:||||:::||||||.||:|||:.||..||:|||
Yeast   139 YEPTSMRAIRARYDPYEQARGRVEQLKQLGHSIDKVEYVLMGGTFMSLPKEYREDFIVKLHNALS 203

  Fly   197 GHSSANVAEAVRYSEKSRTKCIGITIETRPDYCLKRHISDMLSYGCTRLEIGVQSVYEDVARDTN 261
            |.:..::.||:.||::|.|||:|||||||||||.:.|:.|||.||||||||||||:|||||||||
Yeast   204 GFNGNDIDEAILYSQQSLTKCVGITIETRPDYCTQTHLDDMLKYGCTRLEIGVQSLYEDVARDTN 268

  Fly   262 RGHTVRAVCESFQLGKDAGYKIVTHMMPDLPNVDFERDIEQFIEYFENPAFRSDGLKIYPTLVIR 326
            ||||||:|||:|.:.||||||:|:|||||||||..|||||||.||||||.||:||||||||||||
Yeast   269 RGHTVRSVCETFAVSKDAGYKVVSHMMPDLPNVGMERDIEQFKEYFENPDFRTDGLKIYPTLVIR 333

  Fly   327 GTGLYELWKTGRYKSYPPSMLVDLVAKILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALA 391
            ||||||||||||||||..:.||||||:||||||||||:||||||||||||:|||::|||||||||
Yeast   334 GTGLYELWKTGRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVTSGVDNGNLRELALA 398

  Fly   392 RMKDLGTTCRDVRTREVGIQEIHNKVRPYEIELIRRDYVANGGWETFLSYEDPEQDILVGLLRLR 456
            |||||||||||||||||||||:|:||:|.::|||||||.||||||||||||||::|||:||||||
Yeast   399 RMKDLGTTCRDVRTREVGIQEVHHKVQPDQVELIRRDYYANGGWETFLSYEDPKKDILIGLLRLR 463

  Fly   457 KCSPD-TFRPELKGE-CSIVRELHVYGSVVPVNARDPTKFQHQGFGMLLMEEAERIAREEHGSTK 519
            |.|.. |:|.|...: .||||||||||||||:::|||.||||||||.||||||||||:|||||.|
Yeast   464 KASKKYTYRKEFTSQRTSIVRELHVYGSVVPLHSRDPRKFQHQGFGTLLMEEAERIAKEEHGSEK 528

  Fly   520 LAVISGVGTRNYYRKMGYQLDGPYMSKSI 548
            ::||||||.||||.|:||:||||||||.|
Yeast   529 ISVISGVGVRNYYGKLGYELDGPYMSKRI 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp3	NP_608834.1	ELP3	23..548	CDD:273503	397/528 (75%)
ELP3	NP_015239.1	ELP3	32..557	CDD:273503	396/524 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344880
Domainoid	1	1.000	315	1.000	Domainoid score	I195
eggNOG	1	0.900	-	-		E1_COG1243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7105
Inparanoid	1	1.050	824	1.000	Inparanoid score	I56
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62148
OrthoFinder	1	1.000	-	-		FOG0003595
OrthoInspector	1	1.000	-	-		oto100170
orthoMCL	1	0.900	-	-		OOG6_100741
Panther	1	1.100	-	-	LDO	PTHR11135
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R392
SonicParanoid	1	1.000	-	-		X2945
TreeFam	1	0.960	-	-
	15	14.790