DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Elp3 and elp3

DIOPT Version :9

Sequence 1:	NP_608834.1	Gene:	Elp3 / 33649	FlyBaseID:	FBgn0031604	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001014344.2	Gene:	elp3 / 541509	ZFINID:	ZDB-GENE-050327-35	Length:	548	Species:	Danio rerio

Alignment Length:	547	Identity:	459/547 - (83%)
Similarity:	508/547 - (92%)	Gaps:	2/547 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KAKKKLGVGLSRQERQVLVIGEIIQELLKAHEAKKDVNLNRMKSLVASKYGLDSSPRLVDIIAAV 66
            |.|||  ..|||.|..::.|.::|::|::|||..||:|||::|:..::||||.:.||||||||||
Zfish     3 KPKKK--SDLSRAELMMMTIADVIKQLVEAHEEGKDINLNKVKTKTSAKYGLSAQPRLVDIIAAV 65

  Fly    67 PQDAKKILLPKLRAKPIRTASGIAVVAVMCKPHRCPHINMTGNICVYCPGGPDSDFEYSTQSYTG 131
            |...::.|:|||:|||||||||||||||||||||||||:.|||||||||||||||||||||||||
Zfish    66 PPHYRRALVPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTG 130

  Fly   132 YEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLPEEYRDYFIRNLHDALS 196
            ||||||||||:||||:||||||||||||||||||||||||||||||.||||||||||||||||||
Zfish   131 YEPTSMRAIRARYDPYLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALS 195

  Fly   197 GHSSANVAEAVRYSEKSRTKCIGITIETRPDYCLKRHISDMLSYGCTRLEIGVQSVYEDVARDTN 261
            ||:|.||.|||||||:|.|||:|||||||||||||||:||||.||||||||||||||||||||||
Zfish   196 GHTSNNVTEAVRYSERSNTKCVGITIETRPDYCLKRHLSDMLGYGCTRLEIGVQSVYEDVARDTN 260

  Fly   262 RGHTVRAVCESFQLGKDAGYKIVTHMMPDLPNVDFERDIEQFIEYFENPAFRSDGLKIYPTLVIR 326
            ||||||||||||.|.||||:|:|.|||||||||..|||:|||||:|||||||.||||:|||||||
Zfish   261 RGHTVRAVCESFHLAKDAGFKVVAHMMPDLPNVGMERDVEQFIEFFENPAFRPDGLKLYPTLVIR 325

  Fly   327 GTGLYELWKTGRYKSYPPSMLVDLVAKILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALA 391
            ||||||||||||||||.||.||||||:||||||||||||||||||||||||||||||||||||||
Zfish   326 GTGLYELWKTGRYKSYSPSALVDLVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALA 390

  Fly   392 RMKDLGTTCRDVRTREVGIQEIHNKVRPYEIELIRRDYVANGGWETFLSYEDPEQDILVGLLRLR 456
            ||||:||.|||||||||||||||:|||||::|||||||||||||||||||||||||||:||||||
Zfish   391 RMKDMGTECRDVRTREVGIQEIHHKVRPYQVELIRRDYVANGGWETFLSYEDPEQDILIGLLRLR 455

  Fly   457 KCSPDTFRPELKGECSIVRELHVYGSVVPVNARDPTKFQHQGFGMLLMEEAERIAREEHGSTKLA 521
            :|||.:|||||||..|||||||||||||||::|||:|||||||||:||||||||||:||||:|||
Zfish   456 RCSPQSFRPELKGGVSIVRELHVYGSVVPVSSRDPSKFQHQGFGMMLMEEAERIARDEHGSSKLA 520

  Fly   522 VISGVGTRNYYRKMGYQLDGPYMSKSI 548
            ||||||||||||||||:|:||||.|::
Zfish   521 VISGVGTRNYYRKMGYELEGPYMVKNL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp3	NP_608834.1	ELP3	23..548	CDD:273503	450/524 (86%)
elp3	NP_001014344.2	ELP3	37..547	CDD:273503	443/509 (87%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:A0A1C7D1B7	475..478		2/2 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:A0A1C7D1B7	498..500		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587894
Domainoid	1	1.000	373	1.000	Domainoid score	I844
eggNOG	1	0.900	-	-		E1_COG1243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7105
Inparanoid	1	1.050	961	1.000	Inparanoid score	I317
OMA	1	1.010	-	-		QHG62148
OrthoDB	1	1.010	-	-		D178537at33208
OrthoFinder	1	1.000	-	-		FOG0003595
OrthoInspector	1	1.000	-	-		oto40135
orthoMCL	1	0.900	-	-		OOG6_100741
Panther	1	1.100	-	-	LDO	PTHR11135
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R392
SonicParanoid	1	1.000	-	-		X2945
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840