DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp3 and Elp3

DIOPT Version :9

Sequence 1:	NP_608834.1	Gene:	Elp3 / 33649	FlyBaseID:	FBgn0031604	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_003751553.1	Gene:	Elp3 / 100362548	RGDID:	2324506	Length:	566	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	453/566 - (80%)
Similarity:	506/566 - (89%)	Gaps:	17/566 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKAKKK----LGVG-------------LSRQERQVLVIGEIIQELLKAHEAKKDVNLNRMKSLVA 48
            ||.|:|    .|.|             ||..|..:|.||::|::|::|||..|||:||::|:..|
  Rat     1 MKQKRKGAKNAGQGHKGGGGCSEITGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKLKTKTA 65

  Fly    49 SKYGLDSSPRLVDIIAAVPQDAKKILLPKLRAKPIRTASGIAVVAVMCKPHRCPHINMTGNICVY 113
            |||||.|.|||||||||||...:|||:|||:|||||||||||||||||||||||||:.|||||||
  Rat    66 SKYGLSSQPRLVDIIAAVPPHYRKILIPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVY 130

  Fly   114 CPGGPDSDFEYSTQSYTGYEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMC 178
            ||||||||||||||||||||||||||||:||||:||||||:|||||||||||||||||||||||.
  Rat   131 CPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMA 195

  Fly   179 LPEEYRDYFIRNLHDALSGHSSANVAEAVRYSEKSRTKCIGITIETRPDYCLKRHISDMLSYGCT 243
            ||||||||||||||||||||:|.|:.||::|||:|.|||||||||||||||:|||:||||:||||
  Rat   196 LPEEYRDYFIRNLHDALSGHTSNNIYEAIKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCT 260

  Fly   244 RLEIGVQSVYEDVARDTNRGHTVRAVCESFQLGKDAGYKIVTHMMPDLPNVDFERDIEQFIEYFE 308
            |||||||||||||||||||||||:||||||.|.||:|:|:|.|||||||||..|||||||||:||
  Rat   261 RLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFIEFFE 325

  Fly   309 NPAFRSDGLKIYPTLVIRGTGLYELWKTGRYKSYPPSMLVDLVAKILALVPPWTRVYRVQRDIPM 373
            |||||.||||:||||||||||||||||:|||:||.||.|::|||:||||||||||||||||||||
  Rat   326 NPAFRPDGLKLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPM 390

  Fly   374 PLVSSGVEHGNLRELALARMKDLGTTCRDVRTREVGIQEIHNKVRPYEIELIRRDYVANGGWETF 438
            |||||||:||||||||.|||||||..|||||||||||||||::||||::||:|||||||||||||
  Rat   391 PLVSSGVDHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANGGWETF 455

  Fly   439 LSYEDPEQDILVGLLRLRKCSPDTFRPELKGECSIVRELHVYGSVVPVNARDPTKFQHQGFGMLL 503
            ||||||:||||:|||||||||.:|||.||.|..|||||||||||||||::|||||||||||||||
  Rat   456 LSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLL 520

  Fly   504 MEEAERIAREEHGSTKLAVISGVGTRNYYRKMGYQLDGPYMSKSIE 549
            ||||||||.|||||.|:|||||||||||||||||:|.||||.|.::
  Rat   521 MEEAERIALEEHGSGKIAVISGVGTRNYYRKMGYRLQGPYMVKMLK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp3	NP_608834.1	ELP3	23..548	CDD:273503	441/524 (84%)
Elp3	XP_003751553.1	ELP3	56..565	CDD:273503	423/494 (86%)
		Radical_SAM	115..359	CDD:100105	209/243 (86%)
		Radical_SAM_C	333..411	CDD:292816	66/77 (86%)
		Acetyltransf_1	462..555	CDD:278980	73/88 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346514
Domainoid	1	1.000	367	1.000	Domainoid score	I894
eggNOG	1	0.900	-	-		E1_COG1243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7105
Inparanoid	1	1.050	939	1.000	Inparanoid score	I330
OMA	1	1.010	-	-		QHG62148
OrthoDB	1	1.010	-	-		D178537at33208
OrthoFinder	1	1.000	-	-		FOG0003595
OrthoInspector	1	1.000	-	-		oto98383
orthoMCL	1	0.900	-	-		OOG6_100741
Panther	1	1.100	-	-	LDO	PTHR11135
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2945
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770