Protein Alignment l(2)k05819 and TMEM94

DIOPT Version :10

• Sequence 1: NP_722974.1
• Gene: l(2)k05819 / 33644
• FlyBaseID: FBgn0022153
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_016880922.1
• Gene: TMEM94 / 9772
• HGNCID: 28983
• Length: 1410
• Species: Homo sapiens
• Alignment Length: 1643
• Identity: 475/1643 - (28%)
• Similarity: 712/1643 - (43%)
• Gaps: 427/1643 - (25%)

  Fly     1 MAAKRAE--SPEK----RASPEPTLRGLTTKVALRRLHEEIEKRVQLEHERQYGAESPYRKL-RA 58
            |..|:||  .|.:    :..| |:..||:|:.||..|.|::|..:: .|.|:......:::: |:
Human     1 MLFKQAELWMPHQGKGNKGEP-PSALGLSTRKALSVLKEQLEAVLE-GHLRERKKCLTWKEVWRS 63

  Fly    59 AFVKRYD--SPLGWLSIGSSLLASGALLATGM------------LWPALCLLAILSLDLFVVVRE 109
            :|:...:  |...|  .|:||:....||..|.            |..|..|..:|.|:|.::.|:
Human    64 SFLHHSNRCSCFHW--PGASLMLLAVLLLLGCCGGQPAGSRGVGLVNASALFLLLLLNLVLIGRQ 126

  Fly   110 NNLRRTEIFRKARHAISEIKLAEQHFSD-DWQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWAL 173
            :.|:|.|:.|:.|..|.:|:.|.:...: .|..:.||.|..|.:|..||.|.||||.:||||.:|
Human   127 DRLKRREVERRLRGIIDQIQDALRDGREIQWPSAMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSL 191

  Fly   174 LVRGDYIVLRPGHISPGPCHELETNKFFAANEIYGAAPHGD--PPVKPVARPPLP---------- 226
            ||.||.|.||||..|......::.::......       ||  ||..|   ||.|
Human   192 LVEGDIIALRPGQESFASLRGIKDDEHIVLEP-------GDLFPPFSP---PPSPRGEVERGPQS 246

  Fly   227 ----NLVCCLESTPYLDNLTVCLKNSLKRPPTIYNQQRYLLVTKYIQQWGFISALVITLISGLLR 287
                .|...|| ||.:||:..||..:|.||.|..:.:|: .|...:..:.....|...||:..||
Human   247 PQQHRLFRVLE-TPVIDNIRWCLDMALSRPVTALDNERF-TVQSVMLHYAVPVVLAGFLITNALR 309

  Fly   288 LHGYGLPTDEKHNWRFVLVESSAAAIVPLLPLIFPLMWISMNLWGIARL--QCFLKTPQAALEKS 350
               :........:|::.|::.....::|:|||:||::|:.....|.||:  |....:|.:.|.|
Human   310 ---FIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAK- 370

  Fly   351 TSKSFEED-LDTPSYDYQNMSMLRSSVLRIW---MQLWRGDSELLPRSANLVQVLGSISALCCVD 411
                |.|| |.:.:....:..|||.    ||   :::..|.|..|..|::|:..|||::.|||||
Human   371 ----FSEDTLSSYTEAVSSQEMLRC----IWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVD 427

  Fly   412 KKGILSWPNPTAEKVFF-----------------------------------------------L 429
            |:||||||||:.|.|.|                                               |
Human   428 KQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEVEEEPHERDALLAGSLNNTL 492

  Fly   430 HNTDEEAREDGAG-------------------------------SQSSSQSESDDVPVVDED-HK 462
            |.::|:.|.|..|                               ::...:..|...|.::.| ::
Human   493 HLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYE 557

  Fly   463 ERGIVA----EVLDLTHDQHCPFRLEFDDHEWKAHIKSLKPLGLAILLNTCSPLTHEHYAQFCGH 523
            ....|.    |:|.|:.||..|..::|||..|:.|:.|||||||.:|||.|.....|...:|..|
Human   558 AEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDASVTERLCRFSDH 622

  Fly   524 VTAVAMLDKD--LVPVTNRYAYALIESSKSFLHGRCLCELAKQIGFTDHATDRFALEGQLASYRH 586
            :..:|:.:..  ::||...:.               |||||:.||||..|.:.|..|..||.||
Human   623 LCNIALQESHSAVLPVHVPWG---------------LCELARLIGFTPGAKELFKQENHLALYR- 671

  Fly   587 LQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMREN---------PG-GYLSLFTQGTADIILD 641
            |......::....| |...:|.:.|..|.:|:.:::.         |. |...:.:.||||::|:
Human   672 LPSAETMKETSLGR-LSCVTKRRPPLSHMISLFIKDTTTSEPWLRWPAPGTEQMLSHGTADVVLE 735

  Fly   642 CCDDFWDGIDLRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGPQRSGGDCLYL- 705
            .|.|||||.|:.|||..|||:.||||||:.|:.||:||||:|:...:...|:      |.|:.|
Human   736 ACTDFWDGADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCALSSQLN------GKCIELV 794

  Fly   706 ELPPESKLRMQHVDKTHCDFQGGHHVKLSHSISTDSLLFSENKDEECNDV---EGCFEMQCHQVF 767
            ::|.:|.:      .|.|:......:|.:...|      |.:.||...:|   |.|.:....|:|
Human   795 QVPGQSSI------FTMCELPSTIPIKQNARRS------SWSSDEGIGEVLEKEDCMQALSGQIF 847

  Fly   768 IGMVTMQYQAQNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSEPEPD 832
            :|||:.||||:.|||||::.|..||||||:||.|:||:|:||:||||||:||||||||
Human   848 MGMVSSQYQARLDIVRLIDGLVNACIRFVYFSLEDELKSKVFAEKMGLETGWNCHISL------- 905

  Fly   833 SEKERISAKPKEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATASVSESIS 897
                                                            :|....|
Human   906 ------------------------------------------------TPNGDMP---------- 912

  Fly   898 AAKTTEIVGDGPEISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDSEGSKES 962
                      |.||     ||:                                 ||...||...
Human   913 ----------GSEI-----PPS---------------------------------SPSHAGSLHD 929

  Fly   963 SQDSCTKNNPPGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDMSNRAKL 1027
            ..:..::::..|...:|.|    .|....|.               :.||...|...:.||||||
Human   930 DLNQVSRDDAEGLLLMEEE----GHSDLISF---------------QPTDSDIPSFLEDSNRAKL 975

  Fly  1028 PRGIENIRPHLEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANADIFLQAD 1092
            ||||..:||||:.:|||||.|.|||||:.|...:|:.|||.|||:..||||||:..|:.:|||:|
Human   976 PRGIHQVRPHLQNIDNVPLLVPLFTDCTPETMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSD 1040

  Fly  1093 CSIAVEPLYPQVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSPAHTISP 1157
            .|||::||||..|.                |:..              |.....:|...:..:||
Human  1041 ISIALDPLYPSRCS----------------WETF--------------GYATSISMAQASDGLSP 1075

  Fly  1158 LYLSRLLNSLPCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLCACLSQP 1222
            |.||..|||||||:...:::.:|::.:||.:|..:.|:..|..:...|..::.::..|...:..|
Human  1076 LQLSGQLNSLPCSLTFRQEETISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLP 1140

  Fly  1223 PLVTPLLGIYLMCVPVPLIAISLAHIDVDPKIMNRATSKKQTDYDSRAFAFVMWCYGCKFIVLVV 1287
            ||::....::|.|...||::|||........||:.||.|.......:...:.:.|:..||.:.:.
Human  1141 PLLSTTDILWLSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTIS 1205

  Fly  1288 SLLVSYWMLLPN----------TQLNPAEPATEEPVLEIDDDDDPEFYQ-----FLYIARSSALL 1337
            |.|:.:...|.:          |..:..       :|..:||..|.:::     .|...:.:|.|
Human  1206 SCLICFGFTLQSFCDSSRDRNLTNCSSV-------MLPSNDDRAPAWFEDFANGLLSAQKLTAAL 1263

  Fly  1338 GIILHF------------------------------VFISVTFVHRDHALWQRNPFTNRIWAFTC 1372
             |:||.                              ||||:|.|||...||:::|.||..||.|.
Human  1264 -IVLHTGERAPWEGVDDGGRGAPLWKSDPHIAPPSPVFISITHVHRTKPLWRKSPLTNLWWAVTV 1327

  Fly  1373 LFLVLIHGIICFVQLLL---EDFWVQLPNQWLALLILFGGSLLSMLV---SELAKFQENKVNARY 1431
            ..::|...:...|.|.|   .|..|....:.:.||....|.|..:||   :|:.|..|.:|..||
Human  1328 PVVLLGQVVQTAVDLQLWTHRDSHVHFGLEDVPLLTWLLGCLSLVLVVVTNEIVKLHEIRVRVRY 1392

  Fly  1432 QRRARLDFGTKLGMNSPF 1449
            |:|.:|.|.|||||||||
Human  1393 QKRQKLQFETKLGMNSPF 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05819	NP_722974.1	MgtA	<566..>684	CDD:440242	50/127 (39%)
		Cation_ATPase_C	1239..1422	CDD:376368	56/233 (24%)
TMEM94	XP_016880922.1	None