Protein Alignment l(2)k05819 and tmem94

DIOPT Version :10

• Sequence 1: NP_722974.1
• Gene: l(2)k05819 / 33644
• FlyBaseID: FBgn0022153
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_021336056.1
• Gene: tmem94 / 795408
• ZFINID: ZDB-GENE-121130-1
• Length: 1365
• Species: Danio rerio
• Alignment Length: 1622
• Identity: 454/1622 - (27%)
• Similarity: 695/1622 - (42%)
• Gaps: 430/1622 - (26%)

  Fly     1 MAAKRAESPEKRASPEPTLRGLTTKVALRRLHEEIEKRVQLEHERQYGAESPYRKLRA-AFVKRY 64
            |..:..:..|:.|:|    .||:|..||..|.:::...:. :|::........::|.| :|:...
Zfish     1 MELQDKKQEEETATP----LGLSTAQALCTLRDQLSNLLG-QHQKFSRRRPTIQELWAKSFLHHG 60

  Fly    65 D--SPLGWLSIGSSLLASGALLATGMLWP----------ALCLLAILSLDLFVVVRENNLRRTEI 117
            |  |...|.....:|:....||:.....|          |..|..:|.|:||::.|:..||.:|:
Zfish    61 DRHSCFHWPGAVLTLVVVVGLLSCHGSQPEGSQGIELVNAGALFLLLLLNLFLIGRQQRLRISEM 125

  Fly   118 FRKARHAISEIKLAEQHFSDD---WQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWALLVRGDY 179
            .|:.:..||::....:..:..   |..|.||.|..|.||..||.||:||.::||||.:|||.||.
Zfish   126 VRRLKSIISQLNDYLERSAGHPIRWAPSLYPDLYTPTSPSWSLHWTFRDEQLVNLPVSLLVEGDV 190

  Fly   180 IVLRPGHISPGPCHELETNKFFAANEIYGAAPHGD--PPVKPVARPPLPN-------------LV 229
            |.||||..:......::.::......       ||  ||..|   ||.|.             .:
Zfish   191 IALRPGQEAFASLRGIKDDEHIVLEP-------GDLFPPFSP---PPSPRGNERRGPHSPQQYRL 245

  Fly   230 CCLESTPYLDNLTVCLKNSLKRPPTIYNQQRYLLVTKYIQQWGFISALVITLISGLLRLHGYGLP 294
            ..:..||.||::...|..:|.||.|..:.:|: .|...|.::...:.||.......:|   |...
Zfish   246 FRVVRTPILDSVRNSLDLALSRPITALDNERF-TVQSIIAKFACPAVLVAFFSMNTIR---YFCD 306

  Fly   295 TDEKHNWRFVLVESSAAAIVPLLPLIFPLMWISMNLWGIARL--QCFLKTPQAALEKSTSKSFEE 357
            |.......|..::.....::|:|||:||:||:.:|.:|.||:  :....:|...|.|     |.|
Zfish   307 TPGLTPGPFNFLQLQMMGVLPILPLLFPVMWVLVNAYGEARVLAESSRNSPTGLLAK-----FSE 366

  Fly   358 D-LDTPSYDYQNMSMLRSSVLRIWMQL---WRGDSELLPRSANLVQVLGSISALCCVDKKGILSW 418
            | |.:.:....:..|||.    :|..|   .:|:|:.|..:::|:..|||::.||||||:|||||
Zfish   367 DTLSSYTEVVSSQEMLRC----VWRHLVSVLKGESQTLCYTSSLLHTLGSVTVLCCVDKQGILSW 427

  Fly   419 PNPTAEKVFFL-------HNTDEEARED----------------------------------GAG 442
            |||:.|.|.|.       |::.::.|:|                                  ...
Zfish   428 PNPSPETVLFFSGRVEPPHDSQDDLRDDLSVNSLCRTEGEEDRDEPQEGEALLCLPAFEPPLHMA 492

  Fly   443 SQSSSQSESDDVPVVDEDHKERG------------------------------------------ 465
            .|..|::..|.....|...:.||
Zfish   493 EQEPSETSHDTARSSDTQRQRRGPQTTRSKHPSGSNVSFSHDTEGGENDFVQQCGLGDDLCEADD 557

  Fly   466 ----IVAEVLDLTHDQHCPFRLEFDDHEWKAHIKSLKPLGLAILLNTCSPLTHEHYAQFCGHVTA 526
                ...|:|.|:.||..|..::|||..|:.|:.|||||||.||||.|:....:...:|..|::.
Zfish   558 FVCDYHLEMLSLSQDQQNPVSIQFDDSGWQNHLSSLKPLGLNILLNLCNATVTQQLCRFSDHLSN 622

  Fly   527 VAMLDKDLVPVTNRYAYALIESSKSFLHGRC--------LCELAKQIGFTDHATDRFALEGQLAS 583
            :|:.:                     .||..        ||||::.||||..|.:.|..|..||.
Zfish   623 LALQE---------------------CHGAVLPVHVPWGLCELSRLIGFTPGARELFKHENHLAL 666

  Fly   584 YRHLQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMRENPGGYLSLFTQGTADIILDCCDDFWD 648
            |:  .|...:......|:|...:|.:.|..|.:|:.:|:|....:.:.:.|:||:||:.|.||||
Zfish   667 YQ--LPSGEKAKESAPRRLHHFTKRQPPISHLISLFVRDNTTNNVQMLSHGSADLILEACTDFWD 729

  Fly   649 GIDLRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGP--QRSGGDCLY--LELPP 709
            |.|:.|||..|||:.||||||:.|:.||:||||:|::..:.|.|:|.  :.:.|..|:  :|||.
Zfish   730 GADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMQVTLSGQLNGKCVELAPGPALFSGVELPS 794

  Fly   710 ESKLRMQHVDKTHCDFQGGHHVKLSHSISTDSLLFSENKDEECNDVEGCFEMQCHQVFIGMVTMQ 774
            .:.::               |....:|.|:|..:      .|..:.|.|.:....|:|:|||:.|
Zfish   795 TTPIK---------------HGSRRNSWSSDEGI------GEGLEKEDCVQALSGQIFMGMVSSQ 838

  Fly   775 YQAQNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSEPEPDSEKERIS 839
            :||:.|.|||:|:|..||||||:||.|:||||:||:||||||:||||||||...
Zfish   839 FQARLDTVRLIENLVGACIRFVYFSMEDELRSKVFAEKMGLETGWNCHISLTPN----------- 892

  Fly   840 AKPKEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATASVSESISAAKTTEI 904
                                                                             
Zfish   893 ----------------------------------------------------------------- 892

  Fly   905 VGDGPEISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDSEGSKESSQDSCTK 969
             |||                     ...||.|:|.:       :|..|....:.|::.::....
Zfish   893 -GDG---------------------HCDGAPSSPSQ-------AGSLHDELLQDSRDDAEGPLL- 927

  Fly   970 NNPPGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDMSNRAKLPRGIENI 1034
              |...|:|.:                           .:.||...|...:..|||||||||..:
Zfish   928 --PEDQSDLAS---------------------------FQPTDSDVPSFLEDCNRAKLPRGIHQV 963

  Fly  1035 RPHLEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANADIFLQADCSIAVEP 1099
            ||||:.:|||||.|.|||||:.|...:|:.|||...|:..||||||:..|:.:|||:|.||:::|
Zfish   964 RPHLKNIDNVPLLVPLFTDCTPETMCEMMKIMQENREVTCCLGSSANFRNSCLFLQSDISISLDP 1028

  Fly  1100 LYPQVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSPAHTISPLYLSRLL 1164
            |||..|.                |:..              |....|.:......:|||.||..|
Zfish  1029 LYPSRCS----------------WETF--------------GYAAVCGLNEECDELSPLGLSASL 1063

  Fly  1165 NSLPCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLCACLSQ--PPL-VT 1226
            |||.||::..:.:.:|:|.:||.:|..:.|:..|..:...|..::.|:..| |||.|  ||: :|
Zfish  1064 NSLACSVSFHQGESVSMVKLIEQARHTTYGIRKCFLFLLQCQLTLVIIQFL-ACLIQLPPPMNIT 1127

  Fly  1227 PLLGIYLMCVPVPLIAISLAHIDVDPKIMNRATSKKQTDYDSRAFAFVMWCYGCKFIVLVVSLLV 1291
            .:|  :|.|...||:::||.....|..:|..||.|.......:...:.:..:..||.:.|::.||
Zfish  1128 DIL--WLSCFCYPLLSVSLLGKPPDSSVMTVATGKNLDSIPRKTQHYFLGWFLLKFGLTVLAYLV 1190

  Fly  1292 SYWMLL-------------PNTQLNPAEPATEEPVLEIDDDDDPEFYQFLYIARSSALLGI---- 1339
            .:...|             .|:.:|.:.      :|.......||::..|    |:.||.|
Zfish  1191 GFGFSLQEVCSRAANFTKTDNSTINCSH------ILTSSSQGAPEWFGEL----SNGLLLIQKIM 1245

  Fly  1340 ----ILHFVFISVTFVHRDHALWQRNPFTNRIWAFTCLFLVLIHGIICFVQLLLE-DFWVQLPNQ 1399
                .||.|.||.::|||...||:||||:|..|..|...::|  |.:  ||.::: ..|.....:
Zfish  1246 AGFLALHTVVISFSYVHRSQPLWRRNPFSNTWWCLTVPVVLL--GQV--VQAVIDYHLWRNRRTE 1306

  Fly  1400 ------------WLALLILFGGSLLSMLVSELAKFQENKVNARYQRRARLDFGTKLGMNSPF 1449
                        ||.:.:   ..:|.:|::|..|..|.:|..|||:|.:|.|.|||||||||
Zfish  1307 VVFTLHHIPLMVWLLVSL---SIVLVVLINEAVKLHEIRVRVRYQKRQKLQFETKLGMNSPF 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05819	NP_722974.1	MgtA	<566..>684	CDD:440242	49/117 (42%)
		Cation_ATPase_C	1239..1422	CDD:376368	52/216 (24%)
tmem94	XP_021336056.1	MgtA	<1079..1338	CDD:440242	72/278 (26%)