Protein Alignment l(2)k05819 and Tmem94

DIOPT Version :10

• Sequence 1: NP_722974.1
• Gene: l(2)k05819 / 33644
• FlyBaseID: FBgn0022153
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_006534333.1
• Gene: Tmem94 / 71947
• MGIID: 1919197
• Length: 1371
• Species: Mus musculus
• Alignment Length: 1596
• Identity: 477/1596 - (29%)
• Similarity: 710/1596 - (44%)
• Gaps: 372/1596 - (23%)

  Fly     1 MAAKRAE------SPEKRASPEPTLRGLTTKVALRRLHEEIEKRVQLEHERQYGAESPYRKL-RA 58
            |..|:||      .....|...|...||:|:.||..|.|::|..:: :|.::......:::. |:
Mouse     1 MLFKQAELWIPNQGKHSSAGEPPLALGLSTRKALSVLKEQLEAVLE-KHLKERKKSLTWKEAWRS 64

  Fly    59 AFVKRYD--SPLGWLSIGSSLLASGALL-----------ATGM-LWPALCLLAILSLDLFVVVRE 109
            :|:...:  |...|  .|:||:....||           :.|: |..|..|..:|.|:|.::.|:
Mouse    65 SFLHLSNRCSCFHW--PGASLMLLAVLLLLCCCGGQPAGSQGVELVNASALFLLLLLNLVLIGRQ 127

  Fly   110 NNLRRTEIFRKARHAISEIKLAEQHFSD-DWQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWAL 173
            :.|:|.|:.|:.|..|.:|:.|.:...: .|..|.||.|..|.:|..||.|.||||.:||||.:|
Mouse   128 DRLKRREVERRLRGIIDQIQDALRDGKEIKWPNSMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSL 192

  Fly   174 LVRGDYIVLRPGHISPGPCHELETNKFFAANEIYGAAPHGD--PPVKPVARPPLP---------- 226
            ||.||.|.||||..|......::.::......       ||  ||..|   ||.|
Mouse   193 LVEGDIIALRPGQESFASLRGIKDDEHIVLEP-------GDLFPPFSP---PPSPRGEVKRGPQN 247

  Fly   227 ----NLVCCLESTPYLDNLTVCLKNSLKRPPTIYNQQRYLLVTKYIQQWGFISALVITLISGLLR 287
                .|...|| ||.:||:..||..:|.||.|..:.:|: .|...:..:.....|...||:..||
Mouse   248 PQQHRLFRVLE-TPVIDNIRWCLDTALSRPVTALDNERF-TVQSVMLHYAVPVVLAGFLITNALR 310

  Fly   288 LHGYGLPTDEKHNWRFVLVESSAAAIVPLLPLIFPLMWISMNLWGIARL--QCFLKTPQAALEKS 350
               :........:|::.|::.....::|:|||:||::|:.....|.||:  |....:|.:.|.|
Mouse   311 ---FMFKAPGVTSWQYTLLQLQVNGMLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAK- 371

  Fly   351 TSKSFEED-LDTPSYDYQNMSMLRSSVLRIW---MQLWRGDSELLPRSANLVQVLGSISALCCVD 411
                |.|| |.:.:....:..|||.    ||   :::.:|.|..|..||:|:..|||::.|||||
Mouse   372 ----FSEDTLSSYTEAVSSQEMLRC----IWGHFLRVIQGTSPTLSHSASLLHSLGSVTVLCCVD 428

  Fly   412 KKGILSWPNPTAEKVFFL-------HNTDEEARED---------------------GAGS----- 443
            |:||||||||:.|.|.|.       |::.|:..:|                     .|||
Mouse   429 KQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDDLSTRSFCHPEVEEEPHEHDALLAGSLNNTL 493

  Fly   444 -QSSSQSESD---DVPVVDE---DHKERG------------------------------------ 465
             .|:.|..||   |.|...|   .||..|
Mouse   494 HLSNEQERSDWLADGPKPSEPYPHHKGHGRSKHPSGSNVSFSRDTEGGEEEPSKAQPGTEGDPYE 558

  Fly   466 -------IVAEVLDLTHDQHCPFRLEFDDHEWKAHIKSLKPLGLAILLNTCSPLTHEHYAQFCGH 523
                   ...|:|.|:.||..|..::|||..|::|:.|||||||.:|||.|:....|...:|..|
Mouse   559 AEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQSHLTSLKPLGLNVLLNLCNASVTERLCRFSDH 623

  Fly   524 VTAVAMLDKD--LVPVTNRYAYALIESSKSFLHGRCLCELAKQIGFTDHATDRFALEGQLASYRH 586
            :..:|:.:..  ::||...:.               |||||:.||||..|.:.|..|..||.||
Mouse   624 LCNIALQESHSAVLPVHVPWG---------------LCELARLIGFTPGAKELFKQENHLALYR- 672

  Fly   587 LQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMRENPGGYLSLFTQGTADIILDCCDDFWDGID 651
            |......::....|. ...:|.:.|..|.:|:.:::.......:.:.|:||::::.|.|||||.|
Mouse   673 LPSAETLKETSLGRP-SCVTKRRPPLSHMISLFIKDTATSTEQMLSHGSADVVVEACTDFWDGAD 736

  Fly   652 LRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGPQRSGGDCLYL-ELPPESKLRM 715
            :.|||..|||:.||||||:.|:.||:||||:|:...:...|:      |.|:.| ::|.::.:
Mouse   737 IYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCTLSSQLN------GKCIELVQVPGQNSI-- 793

  Fly   716 QHVDKTHCDFQGGHHVKLSHSISTDSLLFSENKDEECNDV---EGCFEMQCHQVFIGMVTMQYQA 777
                .|.|:......:|.::..|      |.:.||...:|   |.|.:....|:|:|||:.||||
Mouse   794 ----FTMCELPSTIPIKPNNRRS------SWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQA 848

  Fly   778 QNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSEPEPDSEKERISAKP 842
            :.|||||::.|..||||||:||.|:||||:||:||||||:||||||||
Mouse   849 RLDIVRLIDGLVNACIRFVYFSLEDELRSKVFAEKMGLETGWNCHISL----------------- 896

  Fly   843 KEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATASVSESISAAKTTEIVGD 907
                                                  :|....|
Mouse   897 --------------------------------------TPNGDMP-------------------- 903

  Fly   908 GPEISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDSEGSKESSQDSCTKNNP 972
            |.||     ||:                                 ||...||.....:..::::.
Mouse   904 GSEI-----PPS---------------------------------SPSHAGSLHDDLNQVSRDDA 930

  Fly   973 PGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDMSNRAKLPRGIENIRPH 1037
            .|...||.|    .|....|.               :.||...|...:..|||||||||..:|||
Mouse   931 EGLLLLEEE----GHSDLISF---------------QPTDSDIPSFLEDCNRAKLPRGIHQVRPH 976

  Fly  1038 LEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANADIFLQADCSIAVEPLYP 1102
            |:.:|||||.|.|||||:.:...:|:.|||.|||:..||||||:..|:.:|||:|.|||::||||
Mouse   977 LQNIDNVPLLVPLFTDCTPDTMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDVSIALDPLYP 1041

  Fly  1103 QVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSPAHTISPLYLSRLLNSL 1167
            ..|.                |:..              |......|...:..:|||.||..||||
Mouse  1042 SRCS----------------WETF--------------GYATSTTMAQASDGLSPLQLSGQLNSL 1076

  Fly  1168 PCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLCACLSQPPLVTPLLGIY 1232
            |||:...:::.:|::.:||.:|..:.|:..|..:...|..::.::..|...:..|||::....::
Mouse  1077 PCSLTFRQEESISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILW 1141

  Fly  1233 LMCVPVPLIAISLAHIDVDPKIMNRATSKKQTDYDSRAFAFVMWCYGCKFIVLVVSLLVSYWMLL 1297
            |.|...||::|||........||:.||.|.......:...:.:.|:..||.:.:.|.||.:...|
Mouse  1142 LSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLVCFGFTL 1206

  Fly  1298 PN-TQLNPAEPAT--EEPVLEIDDDDDPEFYQ-----FLYIARSSALLGIILHFVFISVTFVHRD 1354
            .: .....|...|  ...:|..:||..|.:::     .|...:.:|.| |:||.||||:|.|||.
Mouse  1207 QSFCDSARARNLTNCSSVMLCSNDDRAPAWFEDFANGLLSAQKLTAAL-IVLHTVFISITHVHRT 1270

  Fly  1355 HALWQRNPFTNRIWAFTCLFLVLIHGIICFVQLLL---EDFWVQLPNQWLALLILFGGSLLSMLV 1416
            ..||:::|.||..||.|...::|...:...|.|.|   .|..|....:.:.||....|.|..:||
Mouse  1271 KPLWRKSPLTNLWWAVTVPVVLLGQVVQTVVDLQLWTHRDSRVHFGLEDVPLLTWLLGCLSLVLV 1335

  Fly  1417 ---SELAKFQENKVNARYQRRARLDFGTKLGMNSPF 1449
               :|:.|..|.:|..|||:|.:|.|.|||||||||
Mouse  1336 VVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05819	NP_722974.1	MgtA	<566..>684	CDD:440242	45/117 (38%)
		Cation_ATPase_C	1239..1422	CDD:376368	58/196 (30%)
Tmem94	XP_006534333.1	MgtA	<1089..1344	CDD:440242	71/255 (28%)