DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)k05819 and Tmem94

DIOPT Version :9

Sequence 1:NP_722974.1 Gene:l(2)k05819 / 33644 FlyBaseID:FBgn0022153 Length:1449 Species:Drosophila melanogaster
Sequence 2:XP_006534333.1 Gene:Tmem94 / 71947 MGIID:1919197 Length:1371 Species:Mus musculus


Alignment Length:1596 Identity:477/1596 - (29%)
Similarity:710/1596 - (44%) Gaps:372/1596 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAAKRAE------SPEKRASPEPTLRGLTTKVALRRLHEEIEKRVQLEHERQYGAESPYRKL-RA 58
            |..|:||      .....|...|...||:|:.||..|.|::|..:: :|.::......:::. |:
Mouse     1 MLFKQAELWIPNQGKHSSAGEPPLALGLSTRKALSVLKEQLEAVLE-KHLKERKKSLTWKEAWRS 64

  Fly    59 AFVKRYD--SPLGWLSIGSSLLASGALL-----------ATGM-LWPALCLLAILSLDLFVVVRE 109
            :|:...:  |...|  .|:||:....||           :.|: |..|..|..:|.|:|.::.|:
Mouse    65 SFLHLSNRCSCFHW--PGASLMLLAVLLLLCCCGGQPAGSQGVELVNASALFLLLLLNLVLIGRQ 127

  Fly   110 NNLRRTEIFRKARHAISEIKLAEQHFSD-DWQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWAL 173
            :.|:|.|:.|:.|..|.:|:.|.:...: .|..|.||.|..|.:|..||.|.||||.:||||.:|
Mouse   128 DRLKRREVERRLRGIIDQIQDALRDGKEIKWPNSMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSL 192

  Fly   174 LVRGDYIVLRPGHISPGPCHELETNKFFAANEIYGAAPHGD--PPVKPVARPPLP---------- 226
            ||.||.|.||||..|......::.::......       ||  ||..|   ||.|          
Mouse   193 LVEGDIIALRPGQESFASLRGIKDDEHIVLEP-------GDLFPPFSP---PPSPRGEVKRGPQN 247

  Fly   227 ----NLVCCLESTPYLDNLTVCLKNSLKRPPTIYNQQRYLLVTKYIQQWGFISALVITLISGLLR 287
                .|...|| ||.:||:..||..:|.||.|..:.:|: .|...:..:.....|...||:..||
Mouse   248 PQQHRLFRVLE-TPVIDNIRWCLDTALSRPVTALDNERF-TVQSVMLHYAVPVVLAGFLITNALR 310

  Fly   288 LHGYGLPTDEKHNWRFVLVESSAAAIVPLLPLIFPLMWISMNLWGIARL--QCFLKTPQAALEKS 350
               :........:|::.|::.....::|:|||:||::|:.....|.||:  |....:|.:.|.| 
Mouse   311 ---FMFKAPGVTSWQYTLLQLQVNGMLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAK- 371

  Fly   351 TSKSFEED-LDTPSYDYQNMSMLRSSVLRIW---MQLWRGDSELLPRSANLVQVLGSISALCCVD 411
                |.|| |.:.:....:..|||.    ||   :::.:|.|..|..||:|:..|||::.|||||
Mouse   372 ----FSEDTLSSYTEAVSSQEMLRC----IWGHFLRVIQGTSPTLSHSASLLHSLGSVTVLCCVD 428

  Fly   412 KKGILSWPNPTAEKVFFL-------HNTDEEARED---------------------GAGS----- 443
            |:||||||||:.|.|.|.       |::.|:..:|                     .|||     
Mouse   429 KQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDDLSTRSFCHPEVEEEPHEHDALLAGSLNNTL 493

  Fly   444 -QSSSQSESD---DVPVVDE---DHKERG------------------------------------ 465
             .|:.|..||   |.|...|   .||..|                                    
Mouse   494 HLSNEQERSDWLADGPKPSEPYPHHKGHGRSKHPSGSNVSFSRDTEGGEEEPSKAQPGTEGDPYE 558

  Fly   466 -------IVAEVLDLTHDQHCPFRLEFDDHEWKAHIKSLKPLGLAILLNTCSPLTHEHYAQFCGH 523
                   ...|:|.|:.||..|..::|||..|::|:.|||||||.:|||.|:....|...:|..|
Mouse   559 AEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQSHLTSLKPLGLNVLLNLCNASVTERLCRFSDH 623

  Fly   524 VTAVAMLDKD--LVPVTNRYAYALIESSKSFLHGRCLCELAKQIGFTDHATDRFALEGQLASYRH 586
            :..:|:.:..  ::||...:.               |||||:.||||..|.:.|..|..||.|| 
Mouse   624 LCNIALQESHSAVLPVHVPWG---------------LCELARLIGFTPGAKELFKQENHLALYR- 672

  Fly   587 LQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMRENPGGYLSLFTQGTADIILDCCDDFWDGID 651
            |......::....|. ...:|.:.|..|.:|:.:::.......:.:.|:||::::.|.|||||.|
Mouse   673 LPSAETLKETSLGRP-SCVTKRRPPLSHMISLFIKDTATSTEQMLSHGSADVVVEACTDFWDGAD 736

  Fly   652 LRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGPQRSGGDCLYL-ELPPESKLRM 715
            :.|||..|||:.||||||:.|:.||:||||:|:...:...|:      |.|:.| ::|.::.:  
Mouse   737 IYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCTLSSQLN------GKCIELVQVPGQNSI-- 793

  Fly   716 QHVDKTHCDFQGGHHVKLSHSISTDSLLFSENKDEECNDV---EGCFEMQCHQVFIGMVTMQYQA 777
                .|.|:......:|.::..|      |.:.||...:|   |.|.:....|:|:|||:.||||
Mouse   794 ----FTMCELPSTIPIKPNNRRS------SWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQA 848

  Fly   778 QNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSEPEPDSEKERISAKP 842
            :.|||||::.|..||||||:||.|:||||:||:||||||:||||||||                 
Mouse   849 RLDIVRLIDGLVNACIRFVYFSLEDELRSKVFAEKMGLETGWNCHISL----------------- 896

  Fly   843 KEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATASVSESISAAKTTEIVGD 907
                                                  :|....|                    
Mouse   897 --------------------------------------TPNGDMP-------------------- 903

  Fly   908 GPEISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDSEGSKESSQDSCTKNNP 972
            |.||     ||:                                 ||...||.....:..::::.
Mouse   904 GSEI-----PPS---------------------------------SPSHAGSLHDDLNQVSRDDA 930

  Fly   973 PGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDMSNRAKLPRGIENIRPH 1037
            .|...||.|    .|....|.               :.||...|...:..|||||||||..:|||
Mouse   931 EGLLLLEEE----GHSDLISF---------------QPTDSDIPSFLEDCNRAKLPRGIHQVRPH 976

  Fly  1038 LEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANADIFLQADCSIAVEPLYP 1102
            |:.:|||||.|.|||||:.:...:|:.|||.|||:..||||||:..|:.:|||:|.|||::||||
Mouse   977 LQNIDNVPLLVPLFTDCTPDTMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDVSIALDPLYP 1041

  Fly  1103 QVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSPAHTISPLYLSRLLNSL 1167
            ..|.                |:..              |......|...:..:|||.||..||||
Mouse  1042 SRCS----------------WETF--------------GYATSTTMAQASDGLSPLQLSGQLNSL 1076

  Fly  1168 PCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLCACLSQPPLVTPLLGIY 1232
            |||:...:::.:|::.:||.:|..:.|:..|..:...|..::.::..|...:..|||::....::
Mouse  1077 PCSLTFRQEESISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILW 1141

  Fly  1233 LMCVPVPLIAISLAHIDVDPKIMNRATSKKQTDYDSRAFAFVMWCYGCKFIVLVVSLLVSYWMLL 1297
            |.|...||::|||........||:.||.|.......:...:.:.|:..||.:.:.|.||.:...|
Mouse  1142 LSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLVCFGFTL 1206

  Fly  1298 PN-TQLNPAEPAT--EEPVLEIDDDDDPEFYQ-----FLYIARSSALLGIILHFVFISVTFVHRD 1354
            .: .....|...|  ...:|..:||..|.:::     .|...:.:|.| |:||.||||:|.|||.
Mouse  1207 QSFCDSARARNLTNCSSVMLCSNDDRAPAWFEDFANGLLSAQKLTAAL-IVLHTVFISITHVHRT 1270

  Fly  1355 HALWQRNPFTNRIWAFTCLFLVLIHGIICFVQLLL---EDFWVQLPNQWLALLILFGGSLLSMLV 1416
            ..||:::|.||..||.|...::|...:...|.|.|   .|..|....:.:.||....|.|..:||
Mouse  1271 KPLWRKSPLTNLWWAVTVPVVLLGQVVQTVVDLQLWTHRDSRVHFGLEDVPLLTWLLGCLSLVLV 1335

  Fly  1417 ---SELAKFQENKVNARYQRRARLDFGTKLGMNSPF 1449
               :|:.|..|.:|..|||:|.:|.|.|||||||||
Mouse  1336 VVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)k05819NP_722974.1 Cation_ATPase_C 1239..1422 CDD:295563 58/196 (30%)
Tmem94XP_006534333.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167842672
Domainoid 1 1.000 479 1.000 Domainoid score I417
eggNOG 1 0.900 - - E1_KOG4383
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8831
Inparanoid 1 1.050 480 1.000 Inparanoid score I1451
Isobase 1 0.950 - 0 Normalized mean entropy S7343
OMA 1 1.010 - - QHG52898
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006233
OrthoInspector 1 1.000 - - oto93969
orthoMCL 1 0.900 - - OOG6_104175
Panther 1 1.100 - - LDO PTHR13219
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3439
SonicParanoid 1 1.000 - - X4515
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.830

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