DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k05819 and D1007.15

DIOPT Version :9

Sequence 1:	NP_722974.1	Gene:	l(2)k05819 / 33644	FlyBaseID:	FBgn0022153	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	NP_001348669.1	Gene:	D1007.15 / 172058	WormBaseID:	WBGene00017010	Length:	1170	Species:	Caenorhabditis elegans

Alignment Length:	1422	Identity:	330/1422 - (23%)
Similarity:	562/1422 - (39%)	Gaps:	362/1422 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 WLSIGSSLLASGALLATGMLWPALCLLAILSLDLFVVVRENNLRRT---EIFRKARHAISEIKLA 131
            :|.:||..:.:....::..::..|.|..||     :.|.:|.:|.|   :.:|||..||.|:: .
Worm    69 FLIVGSVDIENRITYSSATVYALLLLYTIL-----LEVWQNRIRSTAFQQKYRKAFDAILEME-K 127

  Fly   132 EQHFSDDWQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWALLVRGDYIVLRPGHISPGPCHELE 196
            ::....::...:...:::.::.|   |..:|||:::.:|..|||.||.|..|||.::|..|...:
Worm   128 QKPTKFNYNPKSLEAVTDDVAVC---QSCFRDGQVMEVPRILLVIGDVITFRPGQVAPCNCETFD 189

  Fly   197 TNKFFAANEIYGAAPHGD------PPVKPV-ARPPLPNLVCCLESTPYLDNLTVCLKNSLKRPPT 254
             .:..|..:........|      .|::|| ||      |.|.   |..::|...|  |....|.
Worm   190 -GRVLAEGDRLSWDIKSDKKSGFVDPLEPVYAR------VTCY---PIKNHLETAL--SADDSPL 242

  Fly   255 IYNQQRYLLVTKYIQQWGFISALVITLISGLLRLHGYGLPTDEK-HNWRFVLVESSAAAIVPLLP 318
            .::.|...::....:.:....||:.:::..::|   :....||. ...|||....| ..::|||.
Worm   243 QFDYQLQYMIHNVFEHYVIPVALLCSILGTIVR---FCYSDDENLFGTRFVFAVPS-LTVLPLLI 303

  Fly   319 LIFPLMWISMNLWGIARLQCFLKTPQAALEKSTSKSFEEDLDTPSYDYQNMSMLRSSVLRIWMQL 383
            |..||:...:.......:..||..|.                    |:::..
Worm   304 LQLPLLLHFVKFINNREVAKFLGLPD--------------------DFESCK------------- 335

  Fly   384 WRGDSELLPRSANLVQVLGSISALCCVDKKGILSWPNPTAEKVFFLHNTDEEAREDGAGSQSSSQ 448
                        :||.:|.||:....||||||||..:|:.|||.|..|   :|.|.|.
Worm   336 ------------DLVSILSSITGTSFVDKKGILSCAHPSIEKVVFATN---QADESGT------- 378

  Fly   449 SESDDVPVVDEDHKERGIVAEVLDLTHDQHCP-----------FRLEFDDHEWKAHIKSLKPLGL 502
                           .||..||::|:.||. |           :.|..||..|:..:.:|.||..
Worm   379 ---------------LGIHLEVMNLSSDQE-PTINSSGQPSNKWTLSMDDPNWQRFLPNLLPLSY 427

  Fly   503 AILLNTCSPLTHEHYAQFCGHVTAVAMLDKDLVPVTNRYAYALIESSKSFLHGRCLCELAKQIGF 567
            .:|||:|.  ..|.:.||..|:..||......:...||               ||:|:|...:||
Worm   428 NLLLNSCK--QSESFHQFVDHLAVVATKVPRTIATANR---------------RCVCQLPSLLGF 475

  Fly   568 TDHATDRFALEGQLASYRHLQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMRENPGGYLSLFT 632
            |..:.|.|....::..:...||.        ...|...:|.:.|...:...:..:....:..|..
Worm   476 TSKSLDNFQGPPKILGFYKKQPG--------EAALPGLTKHRTPIEMAFCTIHDDAKSLHSHLAC 532

  Fly   633 QGTADIILDCCDDFWDGIDLRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGPQR 697
            ||||::::|.|...|:|.::.|:|.:.:....|||.|.::|.:|.|.:|||....:..:|:|.
Worm   533 QGTANLVVDACTHIWNGTEVIPMSKRLKSSVKDFYLRHSMTGHCLAVSYRPCFSKLATSLAGK-- 595

  Fly   698 SGGDCLYLELPPESKLRMQHVDKTHCDFQGGHHVKLSHS-ISTDSLLFSENKDEECNDVEGCFEM 761
                  |:|:|         :::.|...:..  :..||| .|.|.:.:::......:.::..|
Worm   596 ------YVEVP---------LNQEHSKIETA--LPRSHSNESFDEIDYTKTVRTADSAIDQYF-- 641

  Fly   762 QCHQVFIGMVTMQYQAQNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLL 826
             ..|:..|:|.:.|:.....|.::|.|:|.|:|.|:||||||||||||:||:|:|:||||||||.
Worm   642 -TGQILCGLVVLHYEPIPQSVSIIEKLDQICVRPVYFSKENELRSRVFAEKLGIEAGWNCHISLA 705

  Fly   827 SEPEPDSEKERISAKPKEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATAS 891
            .|......|..::                           ||
Worm   706 EEESAPVRKAGVA---------------------------HE----------------------- 720

  Fly   892 VSESISAAKTTEIVGDGPEISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDS 956
                                .:|...|:..:..:.:                 ||:..:..|.|.
Worm   721 --------------------QFLAQKPSRSKFWRRI-----------------ALSESNLESLDC 748

  Fly   957 EGSKESSQDSCTKNNPPGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDM 1021
            |        |..:.:|                              ||..::..:.:.|||
Worm   749 E--------SLARGSP------------------------------SLRKMSVVSAKMAPI---- 771

  Fly  1022 SNRAKLPRGIENIRPHLEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANAD 1086
            .|.|:||.|::|:||||::||||||.|.||||.:..|..:|::|||..||:|:.:||..:.:|:.
Worm   772 PNIARLPTGVQNVRPHLDEVDNVPLLVGLFTDSNTSAVEEMIEIMQENGEVVMVVGSCRNASNSM 836

  Fly  1087 IFLQADCSIAVEPLYPQVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSP 1151
            |:.:|:.|:.|:.:....|:.:|...| ::.||.:                .:...|...|....
Worm   837 IYSKANISVCVDDVEEPACRLLDHPVE-SVNNNVM----------------QISSRLTALATDFR 884

  Fly  1152 AHTISPLYLSRLLNSLPCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLC 1216
            ...:..|.:|        |:.||....:|       |.|.||    ....:|....|::||  :.
Worm   885 LDHVKLLKMS--------SLIVCARHRMS-------SFRHSL----LFILYASLLYSVTIL--MS 928

  Fly  1217 ACLSQPPLVTPLLGIYLMCVPVPLIAISLAHIDVDPKI-MNRATSKKQTDYDS----RAFAFVMW 1276
            .....|.:.|....|....:.:|::.:.......:||. :.|...|..::...    :..:..:|
Worm   929 TFFFLPIIFTHSQTILTSFLHIPVLFLGTLFTSFEPKSKIIRIAPKNSSEIPKVEKLKTVSQFIW 993

  Fly  1277 CYGCKFIVLVVSLLVSYWMLLPNTQL-----------NPAEPATEEPVLEIDDDDDPEFYQFLYI 1330
            .:....:.:.:..|:   :|:.|:.|           |....|..:|:||.::....:.......
Worm   994 QFVPSAVYINILFLI---LLMANSNLMCSFSDISCLFNTDGSAGSQPLLEFNETRLGQVSLSTET 1055

  Fly  1331 ARSSALLGIILHFVFISVTFVHRDHALWQRNPFTNRIW---AFTCLFLVLIHGIICFVQLLLEDF 1392
            .|....|.|.:.:..:|.:||:...:||...|....:|   ...||...:.:..:..|.  |.|.
Worm  1056 IRHIIGLQITVIYCVLSSSFVYGLSSLWYEFPIKCLLWDAAVIVCLITQIGYSYLRGVH--LSDL 1118

  Fly  1393 WVQLPNQWLALLILFGGSLLSMLVSELAKFQENKVNARYQRRARLDFGTKLGMNSPF 1449
            :..||     |.|||....:.::|:||.|.:..:...|.|||.:.:|.||||||||:
Worm  1119 FSLLP-----LGILFIWICIIVIVNELIKIRRIRQFTREQRRTKFEFDTKLGMNSPY 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05819	NP_722974.1	Cation_ATPase_C	1239..1422	CDD:295563	39/201 (19%)
D1007.15	NP_001348669.1	E1-E2_ATPase	141..>190	CDD:332568	17/52 (33%)
D1007.15	NP_001348669.1	E1-E2_ATPase	<902..1155	CDD:332568	54/275 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162554
Domainoid	1	1.000	314	1.000	Domainoid score	I702
eggNOG	1	0.900	-	-		E1_KOG4383
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8831
Inparanoid	1	1.050	314	1.000	Inparanoid score	I1540
Isobase	1	0.950	-	0	Normalized mean entropy	S7343
OMA	1	1.010	-	-		QHG52898
OrthoDB	1	1.010	-	-		D29125at33208
OrthoFinder	1	1.000	-	-		FOG0006233
OrthoInspector	1	1.000	-	-		oto19387
orthoMCL	1	0.900	-	-		OOG6_104175
Panther	1	1.100	-	-	LDO	PTHR13219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.720