Protein Alignment l(2)k05819 and tmem94

DIOPT Version :10

• Sequence 1: NP_722974.1
• Gene: l(2)k05819 / 33644
• FlyBaseID: FBgn0022153
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_017953417.2
• Gene: tmem94 / 100379863
• XenbaseID: XB-GENE-5900317
• Length: 1336
• Species: Xenopus tropicalis
• Alignment Length: 1560
• Identity: 474/1560 - (30%)
• Similarity: 689/1560 - (44%)
• Gaps: 368/1560 - (23%)

  Fly    21 GLTTKVALRRLHEEIEKRVQLEHERQYGAESPYRKLRAAFV--KRYDSPLGWLSIGSSLLASGAL 83
            ||||..||.||.|::...:. .|:|| ..:.|::.....|:  |...|...|......|||:..|
 Frog    14 GLTTHQALSRLQEQLSAELS-NHQRQ-KKKVPWKDWMRTFLYHKNRSSCFHWPGAALMLLATLLL 76

  Fly    84 LATGMLWP----------ALCLLAILSLDLFVVVRENNLRRTEIFRKARHAISEIK-LAEQHFSD 137
            |......|          |..||.:|.||||::.|...|::.|:.|:....|.:|| :..:....
 Frog    77 LCCFGSQPQGGQGSEVGNACALLTLLLLDLFLMRRLEILKQQEVERRLIKIIDDIKDILSRGTEL 141

  Fly   138 DWQQSNYPHLSNPMSPCVSLQWTYRDGKIVNLPWALLVRGDYIVLRPGHISPGPCHELETNKFFA 202
            .|..:.||.|..|.:|..||.|.||||::||||.:|||.||.|.||||..|......::.::...
 Frog   142 VWGDALYPDLYMPSAPSWSLHWAYRDGRLVNLPVSLLVDGDVIALRPGQESFASVRGIKDDEHIV 206

  Fly   203 --ANEIYGAAPHGDPPVKP------VARPPLPNLVCCLESTPYLDNLTVCLKNSLKRPPTIYNQQ 259
              ..:::   |...||..|      |.:.|..:.:..:..||.|||:...|..:|.||.|..:.:
 Frog   207 LEPGDLF---PPFTPPPSPRAEGKRVPQDPQQHHLFRVTRTPVLDNVRNWLDQALSRPVTALDNE 268

  Fly   260 RYLLVTKYIQQWGFISALVITLISGLLRL--HGYGLPTDEKHNWRFVLVESSAAAIVPLLPLIFP 322
            || .|...:......|.:...||:..:||  ...|:|.     |.:.|::....|::|:|||:||
 Frog   269 RY-TVQSVMLMHAVPSIVAAFLITNAVRLIFSAPGIPP-----WPYALLQLQVNAVLPVLPLLFP 327

  Fly   323 LMWISMNLWGIARLQCFLKT--PQAALEKSTSKSFEED-LDTPSYDYQNMSMLRSSVLRIWMQLW 384
            :|||.:...|.||:...:.|  |.:.:.|     |.|| |.:.:.......|:|..... ::|:.
 Frog   328 VMWILVTALGEARVLAQMSTTSPTSLMAK-----FSEDTLSSYTEVVSAQEMMRCLCFH-FLQVL 386

  Fly   385 RGDSELLPRSANLVQVLGSISALCCVDKKGILSWPNPTAEKV-FFLHNTDEEA-REDGAGSQSSS 447
            ||.||:|..:::|:..|||::.||||||:|:||||||..|.| ||....|:.. |.|..|.|.|.
 Frog   387 RGKSEILAYTSSLLHGLGSVTVLCCVDKQGVLSWPNPCPETVLFFSGRVDQTTDRHDDGGDQMSL 451

  Fly   448 QS------------------ESDDVPVVDED-----------------------HKERGIVA--- 468
            :|                  ::|.:.:|:|.                       |.....|:
 Frog   452 RSYCQADLEEEPQEMVALLTDTDAMQLVNEQESPERQGDSKTSDPPRKGHSRTKHTSGSNVSFSQ 516

  Fly   469 -------------------EVLDLTHDQHCPFRLEFDDHEWKAHIKSLKPLGLAILLNTCSPLTH 514
                               |:|.|:.||..|..::||:..|:.|:.|||||||.:|||.|:|...
 Frog   517 DTAGTGNSEIDDYVCDCHLEMLRLSQDQQNPQSIQFDESNWQVHLSSLKPLGLNVLLNLCNPAVT 581

  Fly   515 EHYAQFCGHVTAVAMLDKDLVPVTNRYAYALIESSKSFLHGRC---LCELAKQIGFTDHATDRFA 576
            ....:|..|:..:                ||.|:..|.|.|..   ||:.::.||||..|.|.|.
 Frog   582 ATLCRFSDHLRHI----------------ALQETHCSVLPGHIPWGLCDFSRLIGFTPGAKDLFK 630

  Fly   577 LEGQLASYRHLQPDVVRRDIRFARQLQLSSKVKVPFPHSLSVVMRENPGGYLSLFTQGTADIILD 641
            ||..:|.| ||..|...:| ....:|..|:|.:.|..|.:|:.:::.......:.:.|||||||:
 Frog   631 LENHVALY-HLPNDEAVKD-NLLSKLSASAKRRPPLSHMISLFVKDVTTNTEQMLSHGTADIILE 693

  Fly   642 CCDDFWDGIDLRPLSAQDRKRALDFYQRSALTSYCTAFAYRPLRHGIHGALSGPQRSGGDCL-YL 705
            .|.|||||.|:.|||..|||:.||||||:.|:.||:||:|:|:.:.:...|.      |.|: .|
 Frog   694 ACTDFWDGTDIYPLSGSDRKKVLDFYQRACLSGYCSAFSYKPMHYSLSPHLH------GKCIELL 752

  Fly   706 ELPPESKLRMQHVDKTHCDFQGGHHVKLS--HSISTDSLLFSENKDEECNDV-EGCFEMQCHQVF 767
            ..|..|.|      ....||.|...||..  |.        |.:.||...:| |...:....|:|
 Frog   753 HAPGHSAL------SAPWDFAGSIAVKPGGRHD--------SWSSDEGIGEVIEDFTQALSGQIF 803

  Fly   768 IGMVTMQYQAQNDIVRLVEHLEQACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSEPEPD 832
            :|||:.||||:.|||||::.|..||||||:||.|:||:|:||:||||||:||||||||...
 Frog   804 MGMVSSQYQARLDIVRLIDGLVNACIRFVYFSMEDELQSKVFAEKMGLETGWNCHISLTPN---- 864

  Fly   833 SEKERISAKPKEFPENIGKPQATTSTTATTTTTDHENNHHPSAKVMYISPPAPAPATASVSESIS 897
                                                                             
 Frog   865 ----------------------------------------------------------------- 864

  Fly   898 AAKTTEIVGDGP--EISYLLGPPNNLESSKTLSSSAPGAISNPDENPLNALNSGDSHSPDSEGSK 960
                    ||||  |:     ||:                                 ||...||.
 Frog   865 --------GDGPGSEV-----PPS---------------------------------SPSHAGSL 883

  Fly   961 ESSQDSCTKNNPPGDSELEAETEANKHKQRHSLDSAMDENCRSLSTLTESTDQSAPINFDMSNRA 1025
            .......::::..|...:|.|    .|....|.               :.||...|...:.||||
 Frog   884 RDDLHQASRDDAEGLLLMEDE----GHSDMISF---------------QPTDSDVPSFLEDSNRA 929

  Fly  1026 KLPRGIENIRPHLEQVDNVPLQVSLFTDCSAEATRQMLDIMQSYGEIVVCLGSSASNANADIFLQ 1090
            ||||||..:||||:.:|||||.|.|||||:.|...:|:.|||.|||:...:|||||..|:.:|||
 Frog   930 KLPRGIHQVRPHLQNIDNVPLLVPLFTDCTQETMCEMIQIMQEYGEVTCSIGSSASIRNSGLFLQ 994

  Fly  1091 ADCSIAVEPLYPQVCQDVDAYTEANIQNNKLLWQRHSGKSKGNDDEELLEGGLHGCAMQSPAHTI 1155
            :|.||.::||||..|.                |:              :.|.:.|...::.:..:
 Frog   995 SDISICLDPLYPSRCS----------------WE--------------MFGYVSGPLRKTASEEL 1029

  Fly  1156 SPLYLSRLLNSLPCSIAVCRDDPLSLVAIIELSRRFSLGLWNCIQYWACCAGSISILNVLCACLS 1220
            |||.||..||.|||||:..:::.:.::.:||.:|..:.|:..|..:...|..::.|:..|...|.
 Frog  1030 SPLQLSAALNCLPCSISFRQEECVGIIRLIEQARHSTYGIRKCFLFLLQCQLTLVIVQFLACLLQ 1094

  Fly  1221 QPPLVTPLLGIYLMCVPVPLIAISLAHIDVDPKIMNRATSKKQTDYDSRAFAFVMWCYGCKFIVL 1285
            .||:::....::|.|...||:::||.....|..||..||.|.......:...:.:.|:..||:..
 Frog  1095 LPPILSTTDILWLSCFCYPLLSVSLLGKPPDNSIMGVATGKNLRAIPKKTQHYFLLCFLLKFLPS 1159

  Fly  1286 VVSLLVSYWMLLP--------NTQLNPAEPATEEPVLEIDDDDDPEFYQFLYIA------RSSAL 1336
            ....|..:|..|.        :...|.:..||               |.:..:|      .|.||
 Frog  1160 CCCCLACFWFSLQRFCEISAHSNSTNCSGIAT---------------YSYSVVAPDWFGSLSGAL 1209

  Fly  1337 L--------GIILHFVFISVTFVHRDHALWQRNPFTNRIWAFTCLFLVLIHGIICFVQLLLEDFW 1393
            |        .|:||.|||||:.|||...||:.:||.|..|:.|...|||..|:...:.|.|   |
 Frog  1210 LLAQKLSACLIVLHIVFISVSHVHRSKPLWKGSPFRNWWWSATLPVLVLAQGLQAALDLQL---W 1271

  Fly  1394 VQLP-----NQW-LALLILFGGSL---LSMLVSELAKFQENKVNARYQRRARLDFGTKLGMNSPF 1449
            ....     :.| :.||....|:|   :.::::||.|..|.:|..|||:|.:|.|.|||||||||
 Frog  1272 TNKDTPLTFHLWDIPLLTWLLGTLSLIVILVINELVKLHEIRVRVRYQKRQKLQFETKLGMNSPF 1336

  Fly  1450  1449
             Frog  1337  1336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05819	NP_722974.1	MgtA	<566..>684	CDD:440242	52/117 (44%)
		Cation_ATPase_C	1239..1422	CDD:376368	57/213 (27%)
tmem94	XP_017953417.2	MgtA	<1055..1309	CDD:440242	70/271 (26%)