DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3652 and YIPF6

DIOPT Version :9

Sequence 1:	NP_608828.2	Gene:	CG3652 / 33643	FlyBaseID:	FBgn0031600	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_776195.2	Gene:	YIPF6 / 286451	HGNCID:	28304	Length:	236	Species:	Homo sapiens

Alignment Length:	222	Identity:	113/222 - (50%)
Similarity:	163/222 - (73%)	Gaps:	15/222 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLDMFEDVNTSPSLEGDMSIPGKRTTTATSASGVPEY--NTLDEPIRETVLRDIRAVGIKFYHV 65
            |.:.:.:|:    .:||:::||.:        |.:.|:  :||:|.:|.|::||::|||.||.||
Human    24 SDISISQDI----PVEGEITIPMR--------SRIREFDSSTLNESVRNTIMRDLKAVGKKFMHV 76

  Fly    66 LYPKEKSSLLRDWDLWGPLVLCTFMATILQGSSTADSMSDNGPEFAQVFVIVWIGAAVVTLNSKL 130
            |||::.::|||||||||||:||..:|.:||..| |||..|.||:||:||||||.||..:||||||
Human    77 LYPRKSNTLLRDWDLWGPLILCVTLALMLQRDS-ADSEKDGGPQFAEVFVIVWFGAVTITLNSKL 140

  Fly   131 LGGNISFFQSVCVLGYCLTPVAISLIVCRVILLATQTRLLFFLRFVTTTIGFAWATYASFVFLGQ 195
            ||||||||||:||||||:.|:.:::::||::|||....:.|.:|.....:.|||:..||..||..
Human   141 LGGNISFFQSLCVLGYCILPLTVAMLICRLVLLADPGPVNFMVRLFVVIVMFAWSIVASTAFLAD 205

  Fly   196 SQPPHRKPLAVYPIFLFFFIISWLVLS 222
            ||||:|:.|||||:|||:|:|||::|:
Human   206 SQPPNRRALAVYPVFLFYFVISWMILT 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3652	NP_608828.2	Yip1	<31..221	CDD:304430	106/191 (55%)
YIPF6	NP_776195.2	Yip1	<54..231	CDD:389810	103/177 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147995
Domainoid	1	1.000	183	1.000	Domainoid score	I3449
eggNOG	1	0.900	-	-		E1_COG5080
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15501
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3335
Isobase	1	0.950	-	0	Normalized mean entropy	S1968
OMA	1	1.010	-	-		QHG54214
OrthoDB	1	1.010	-	-		D1287193at2759
OrthoFinder	1	1.000	-	-		FOG0004230
OrthoInspector	1	1.000	-	-		oto90738
orthoMCL	1	0.900	-	-		OOG6_102338
Panther	1	1.100	-	-	LDO	PTHR21236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1889
SonicParanoid	1	1.000	-	-		X3490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750