DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tps1 and tps-1

DIOPT Version :9

Sequence 1:	NP_608827.1	Gene:	Tps1 / 33642	FlyBaseID:	FBgn0027560	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001041302.1	Gene:	tps-1 / 181778	WormBaseID:	WBGene00006602	Length:	1331	Species:	Caenorhabditis elegans

Alignment Length:	899	Identity:	192/899 - (21%)
Similarity:	334/899 - (37%)	Gaps:	233/899 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EPSTKASLIVVS---------NRLPFVLIRDPKTDELERRASAGGLVTAVCPVV-IKGSGLWVGW 67
            ||.|::.|:.:|         :..|.|.|....:...|.:..:||||..|.||: .....:|:..
Worm   309 EPHTQSPLVDMSHDKQRVINVSNAPPVSISRKTSGSWEIKQGSGGLVACVDPVMSADKKNIWLSN 373

  Fly    68 SGIHLKDP------------------------------NEAIPESNPNDQTPTAGLK-------- 94
            .|:::::.                              ||...|..|..|...:.:.
Worm   374 LGVNMQEELKEHSTSTNSLGLPLIKQACAGEVFCVLERNEKKEELTPKQQAVESDMSLLSVLNTY 438

  Fly    95 ---SEQVVSVNIDSKIFDSYYNGCCNKIFWPLFHSMPGRAN--FGG-----EHWHDYVTVNKHFA 149
               |.|:..|.::...:::||.|..|.:.||..|::|...:  |..     |.|..||.||..||
Worm   439 NKHSYQLNPVVVNQDDYNTYYGGISNGLLWPALHNLPQYISPCFDDPELLREQWCAYVRVNYLFA 503

  Fly   150 VRTIEALEKCLAKNQGSEKSPPIVWIHDYHLMLAANWVREHAEEKNLPCRLAFFLHIPFPPWDIF 214
            :..        |:|   .::...:|||||||||....:|  :.|.:|.  :.||:||||.|...|
Worm   504 INA--------ARN---SRAQDFIWIHDYHLMLCGQIMR--SLESSLD--IGFFIHIPFQPPANF 553

  Fly   215 --RLLPWSDEILQGMLGCDLVGFHIQDYCLNFVDCCQRNL-------GCRVDRNNLLVEHGGRTV 270
              :....:|.|::.:|....|||........||....:::       ..|:||  ..:||.|.|.
Worm   554 MTKYKTVADPIMRALLRFTKVGFQTSRDRDTFVKLVAKHIKRTKIEYDSRLDR--YTIEHDGWTC 616

  Fly   271 RVRPLPIGIPYERFVNLATTAPKVLKTSKM------------QIILGVDRLDYTKGLVHRLMAFE 323
            .:...|:.|....|||:|.....:::..::            |:...|:|.|||||:..:|.|::
Worm   617 SLGVFPVSIKIADFVNIAKNPQTIIEAEEIKKQIMGRSADGGQLFFSVERFDYTKGISEKLRAWQ 681

  Fly   324 ALLLKYPQHKEKVSLLQISVPSRTDVKEYRELKEEVDQLVGRINGRFTTAN---WAPIRYIYDYV 385
            ....|||....|..|.|::|.:|..|..||:.:::|..:...||.:|.:.:   |.|:.:..|.:
Worm   682 RYFEKYPDRIGKDVLFQVAVTNRRSVDSYRQYQDDVLAVADLINQKFKSEDYPEWKPVIFETDGL 746

  Fly   386 SQDELAALYRDAAVCLVTPLRDGMNLVAKEFVACQINEVPGVLVISPFAGAGEMMHEALLCNPYE 450
            .:..|.|.|....:.:|||.:|||||||||.:.|   .....||:|..||....:..|...:..|
Worm   747 PRTRLIAHYLAMDIGVVTPSKDGMNLVAKEMLVC---NPTASLVLSTGAGTEVQLSNAQFYSEQE 808

  Fly   451 ------VNEA------AEVIHRALTMPEDERVLRMARLRRREAECDVSHWMRCFL------KAVG 497
                  |.|.      |:....|.|..::.|.....::.:.....|:..|...||      :.:.
Worm   809 GKCYHRVEEISNTEAFADNFFAAATESKETRTKHGEKINQFLCVHDIDEWSDQFLDPKWTHEVIS 873

  Fly   498 ALEMDDVG-------------TTIMQPV------------SVDDFDDYLLKYIGYNHKLALLLD- 536
            ..|:..:|             ..|::.|            |:::..:.|........||:|..|
Worm   874 QCEVKQLGQFYGLMSRTAQVRRQIVECVLKGLPIRPHFRYSLENAKNSLESSCKSGTKLSLEADE 938

  Fly   537 -----------YDGTLAPIAPHPDLATLSPEIKNVLYKLSNHSDVYVAVISGRNVDNVKKMVGIE 590
                       ||       .|.:|:.:..::            .::|.|.....:|.::.:...
Worm   939 ESGEEKGFEITYD-------IHDELSEMEKDL------------AFLAFIQSDEYENAEEFIKTL 984

  Fly   591 GITYAGNHGLEILHPDGSKFVHPMPMEYEKKVSDLLKALQDSVCRDGAWVENKGALLTF--HYRE 653
            |..|.|.                 |:.::.:|....:.||..:..:..:.:..|.|.::  .|
Worm   985 GSFYEGG-----------------PVLFKNEVKQAAEMLQQGIHYNTFFTDRDGTLKSYACSY-- 1030

  Fly   654 TPNHLRGAMVDKARSLIEKYGFKATEAHCALEARPPV------------------------QWNK 694
             |..::.|.    .::|:....:.....||:....|:                        :|..
Worm  1031 -PTSVQPAY----SAVIQAQFARRCATFCAIVTTAPLLHTGILEVATIPEGYYAYGASAGREWYL 1090

  Fly   695 GRASIYILRTSFGVDWNERIKIIYVGDDLTDEDAMVALKGMARTFRVTSSDIVK 748
            ..|..:..|:...:|.|...|:..:.::|.:....       |.|:...|.|.|
Worm  1091 NPAQQFKDRSFSAIDLNLMNKVFDIIEELLERPEF-------RIFKWIGSGIQK 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tps1	NP_608827.1	GT1_TPS	19..495	CDD:99963	144/575 (25%)
		PRK14501	20..766	CDD:184712	189/892 (21%)
		HAD_like	530..770	CDD:304363	39/257 (15%)
tps-1	NP_001041302.1	GT1_TPS	325..801	CDD:99963	130/495 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166397
Domainoid	1	1.000	158	1.000	Domainoid score	I2509
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76698at33208
OrthoFinder	1	1.000	-	-		FOG0000556
OrthoInspector	1	1.000	-	-		otm14424
orthoMCL	1	0.900	-	-		OOG6_100616
Panther	1	1.100	-	-	LDO	PTHR10788
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16616
SonicParanoid	1	1.000	-	-		X473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880