DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps53 and VPS53

DIOPT Version :9

Sequence 1:	NP_608825.2	Gene:	Vps53 / 33640	FlyBaseID:	FBgn0031598	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001121631.1	Gene:	VPS53 / 55275	HGNCID:	25608	Length:	832	Species:	Homo sapiens

Alignment Length:	901	Identity:	423/901 - (46%)
Similarity:	564/901 - (62%)	Gaps:	121/901 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IHFSKEVKQVIDKVLKTDDPMDAPDFNTVDYINQLFPNEQSLAGIDETIQKMQCEVSLIDDNIRS 84
            :..:.||:..|::|..:.||:|..|||.|:|||.|||.|||||.|||.:.|::.::..:|||||:
Human    17 LQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRT 81

  Fly    85 VVRGQTNTGQDGQLALCEAQKVISSLFSHIIDVKTRAERTEEMVKEITRDIKQLDCAKRNLTAAI 149
            |||||||.||||:.||.||||.|..||..|.|:|.:||::|:|||||||||||||.|||:||.:|
Human    82 VVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSI 146

  Fly   150 TTLNHLHMLVGGIESLNKLIERRSYGEILNPLQAITEVNQHFQQFSDIEEIKNLSQSVDKIQVTL 214
            |||||||||.||::||..:..||.|||:.|.||.:..|.:||.::..|.:|:.||:.|...|..|
Human   147 TTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTEL 211

  Fly   215 AQQITEDFKEAFSAKPSSQNQHRLG--LNQLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLF 277
            .|||..||:|||    .||...|.|  .|.|.|||.|.::|||::|:|::|.||.|.|.||..||
Human   212 GQQILADFEEAF----PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLF 272

  Fly   278 HENQDIAWLDKIDKRYAWLKRHLLDFEDKYGPVFPLDWEVSERITVEFCRQTREQLAQIMAKRTN 342
            .||||:|||||||:||||:||.|:|:|:|||.:||.:|.::|||.||||..||.:||:||..|..
Human   273 QENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAK 337

  Fly   343 EIDVRLLLFAINKTQAFEQLLSKRFTGVTL--GA-----------------QPTDKARVLA---- 384
            ||:|:||||||.:|..||..|:|||:|.||  |.                 :||.:...||
Human   338 EIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKG 402

  Fly   385 ------EPTTTDGAVGLTVFHDQIGQCFKPHLDIYIRSIDRNLSELMDKFV---EMSREPYKFAE 440
                  :|...|..     ||..:.:||:|||.:||.|.|:||.||:|:||   :....|....:
Human   403 DLDQPKKPKAPDNP-----FHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTD 462

  Fly   441 AKTTVYPSSGDLFVFYKKCMVQCNQLSNEQPMYDLALVFKKYLREYASKVLEGSTPKLVPATTSS 505
            ....|.||..||||:||||||||:|||..:||..|..:|:|||||||.|:|.|:.||    ||:|
Human   463 EGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPK----TTTS 523

  Fly   506 SIGKSVSLLTRDMQNLSTAAGQVFHNFLKEG-DTQRFARDDLVRICCVLTTGEYCLETVQQLEDK 569
            |.|.::|.|.::                ||| :..:|..::|..||.:|:|.||||.|.||||:|
Human   524 SGGLTISSLLKE----------------KEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEK 572

  Fly   570 LKEKVTSAYVSKIDMSEEKDVFHRIISNCIQLLVQDLEAGCEASLQAMAKVQWQHINNVGDQSAF 634
            |||||..:.:.:|:::.|.|.|..:||:.||||||||:|.|:.:|.||:|:|||::.:|||||.:
Human   573 LKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPY 637

  Fly   635 ISSLCGNFKQTVPTIRDTLASSRKYFTQFCHRFVAAFIPKFINVLYRCKLTLSDGSNNVLGCEQL 699
            ::|:..:.||.||.|||.|||:||||||||.:|..:||||||..|::||      ..:::|.|||
Human   638 VTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCK------PISMVGAEQL 696

  Fly   700 LLDTHSLKTALLELPSVGSSVNRKAPTSYTKVVVKDMTRAEMIIKVVMTPVQPPAHFTQQVLKLL 764
            ||||||||..||:|||:.|.|.||||.||||:|||.|||||||:||||.|.:|...|....:|||
Human   697 LLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLL 761

  Fly   765 PDITIAEYQKILDMKAVKRVDQLQLIDLFKHTASAAAVSGLIEPTTGEEETQGAETVVATSGTTD 829
            .|.....:|||||||.:||.:|..:::|.:....|        |.:|.|          :||
Human   762 TDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPA--------PPSGAE----------SSG--- 805

  Fly   830 DAETSAVPTETTTATSSTPKRAFIFSVGSFTGSADKNADGSSQTGIRKLENLLKKR 885
                      :.:.|:.||::                    ..:.|||||.|:|||
Human   806 ----------SLSLTAPTPEQ--------------------ESSRIRKLEKLIKKR 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps53	NP_608825.2	Vps53_N	42..434	CDD:282020	216/425 (51%)
VPS53	NP_001121631.1	Vps53_N	39..453	CDD:282020	216/422 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..412		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..822		9/78 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147235
Domainoid	1	1.000	403	1.000	Domainoid score	I721
eggNOG	1	0.900	-	-		E1_KOG2180
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6264
Inparanoid	1	1.050	755	1.000	Inparanoid score	I568
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54046
OrthoDB	1	1.010	-	-		D1379600at2759
OrthoFinder	1	1.000	-	-		FOG0004449
OrthoInspector	1	1.000	-	-		oto91590
orthoMCL	1	0.900	-	-		OOG6_102035
Panther	1	1.100	-	-	LDO	PTHR12820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1657
SonicParanoid	1	1.000	-	-		X4236
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800