DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps53 and vps53

DIOPT Version :9

Sequence 1:	NP_608825.2	Gene:	Vps53 / 33640	FlyBaseID:	FBgn0031598	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_005157637.1	Gene:	vps53 / 492817	ZFINID:	ZDB-GENE-041114-199	Length:	832	Species:	Danio rerio

Alignment Length:	894	Identity:	421/894 - (47%)
Similarity:	562/894 - (62%)	Gaps:	108/894 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IHFSKEVKQVIDKVLKTDDPMDAPDFNTVDYINQLFPNEQSLAGIDETIQKMQCEVSLIDDNIRS 84
            :|.:.||:..|::|..:.||:|..|||.|:|||.|||.|||||.|||.:..::.::..:|||||:
Zfish    17 LHLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNNIRLKIRKLDDNIRT 81

  Fly    85 VVRGQTNTGQDGQLALCEAQKVISSLFSHIIDVKTRAERTEEMVKEITRDIKQLDCAKRNLTAAI 149
            |||||||.||||:.||.||||.|..||..|.|:|.:||::|:|||||||||||||.|||:||.:|
Zfish    82 VVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSI 146

  Fly   150 TTLNHLHMLVGGIESLNKLIERRSYGEILNPLQAITEVNQHFQQFSDIEEIKNLSQSVDKIQVTL 214
            |||||||||.||::||..:..:|.|||:.|.||.:..|.:|||::..|.:|:.||:.|...|..|
Zfish   147 TTLNHLHMLAGGVDSLEAMTRKRQYGEVANLLQGVVNVLEHFQKYMGIPQIRQLSERVKAAQSEL 211

  Fly   215 AQQITEDFKEAFSAKPSSQNQHRLGLN-QLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLFH 278
            ..||..||:|.|.|:.|.::.   |.: .|.|||.|.:||||::|:|::|.||.|.|.||..||.
Zfish   212 GTQILADFEETFPAQGSKKSG---GPSIVLRDACLVANVLDPRIKQEIIKKFIRQHLSEYMVLFQ 273

  Fly   279 ENQDIAWLDKIDKRYAWLKRHLLDFEDKYGPVFPLDWEVSERITVEFCRQTREQLAQIMAKRTNE 343
            ||||:|||||||:||||:||.|:|:|:|||.:||.:|.::|||.||||..||.:|.::|..|..|
Zfish   274 ENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPEEWCMTERIAVEFCHITRTELTKLMRTRARE 338

  Fly   344 IDVRLLLFAINKTQAFEQLLSKRFTGVTLGAQP-TDKARVLAEPTT-----TDGAVGLT------ 396
            |:|:||||||.:|..||.||:|||:|.||...| ..|.....|||.     ..|...::
Zfish   339 IEVKLLLFAIQRTTNFEGLLAKRFSGCTLNDGPGQKKPETPLEPTNPFLEDESGEDNVSEKDEDL 403

  Fly   397 -----------VFHDQIGQCFKPHLDIYIRSIDRNLSELMDKFVEMSR---EPYKFAEAKTTVYP 447
                       .||..:.:||:|||.:||.|.|:||.||:|:||...|   .|....:....|.|
Zfish   404 DRPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFRAQGPPKSGTDEGGAVLP 468

  Fly   448 SSGDLFVFYKKCMVQCNQLSNEQPMYDLALVFKKYLREYASKVLEGSTPKLVPATTSSSIGKSVS 512
            |..||||:||||||||:|||..:||..|..:|:|||||||.|:|.|:.||    |:::|.|.::|
Zfish   469 SCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPK----TSTNSGGLTIS 529

  Fly   513 LLTRDMQNLSTAAGQVFHNFLKEG-DTQRFARDDLVRICCVLTTGEYCLETVQQLEDKLKEKVTS 576
            .|.::                ||| :..:|..::|..||.:|:|.||||.|..|||:||||||..
Zfish   530 SLLKE----------------KEGSEVAKFTVEELCLICSILSTAEYCLATTLQLEEKLKEKVDK 578

  Fly   577 AYVSKIDMSEEKDVFHRIISNCIQLLVQDLEAGCEASLQAMAKVQWQHINNVGDQSAFISSLCGN 641
            :.:.:|::|.|.|.|..:|||.||||||||:|.|:.:|.||:|:.||.:.:|||||.:::|:..:
Zfish   579 SLMERINLSGEMDTFSTVISNSIQLLVQDLDAACDPALTAMSKMPWQSVEHVGDQSPYVTSVIMH 643

  Fly   642 FKQTVPTIRDTLASSRKYFTQFCHRFVAAFIPKFINVLYRCKLTLSDGSNNVLGCEQLLLDTHSL 706
            .||.||.|||.|||:||||||||.:|..:|||||||.|:|||      ..:::|.||||||||||
Zfish   644 IKQNVPIIRDNLASTRKYFTQFCIKFTNSFIPKFINHLFRCK------PISMVGAEQLLLDTHSL 702

  Fly   707 KTALLELPSVGSSVNRKAPTSYTKVVVKDMTRAEMIIKVVMTPVQPPAHFTQQVLKLLPDITIAE 771
            ||.||:|||:||.|.||||.||||:|||.|||||||:||||.|.:|...|....:|||.|.....
Zfish   703 KTVLLDLPSIGSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPSVVFVDNYIKLLADSNPET 767

  Fly   772 YQKILDMKAVKRVDQLQLIDLFKHTASAAAVSGLIEPTTGEEETQGAETVVATSGTTDDAETSAV 836
            :|||||||.:||.:|..:::||:..        |..|.:|.:   |..: ::.|..|.:.|:|.
Zfish   768 FQKILDMKGLKRSEQSTMLELFRQR--------LPTPPSGPD---GGPS-LSFSAPTPEQESSR- 819

  Fly   837 PTETTTATSSTPKRAFIFSVGSFTGSADKNADGSSQTGIRKLENLLKKR 885
                                                  |||||.|:|||
Zfish   820 --------------------------------------IRKLEKLIKKR 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps53	NP_608825.2	Vps53_N	42..434	CDD:282020	211/418 (50%)
vps53	XP_005157637.1	Vps53_N	39..452	CDD:282020	210/415 (51%)
vps53	XP_005157637.1	VPS53_C	<692..>776	CDD:293459	55/83 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580743
Domainoid	1	1.000	397	1.000	Domainoid score	I715
eggNOG	1	0.900	-	-		E1_KOG2180
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6264
Inparanoid	1	1.050	754	1.000	Inparanoid score	I538
OMA	1	1.010	-	-		QHG54046
OrthoDB	1	1.010	-	-		D1379600at2759
OrthoFinder	1	1.000	-	-		FOG0004449
OrthoInspector	1	1.000	-	-		oto39240
orthoMCL	1	0.900	-	-		OOG6_102035
Panther	1	1.100	-	-	LDO	PTHR12820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1657
SonicParanoid	1	1.000	-	-		X4236
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800