DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps53 and vps53

DIOPT Version :9

Sequence 1:	NP_608825.2	Gene:	Vps53 / 33640	FlyBaseID:	FBgn0031598	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_593341.1	Gene:	vps53 / 2542930	PomBaseID:	SPAC3A12.15	Length:	756	Species:	Schizosaccharomyces pombe

Alignment Length:	827	Identity:	196/827 - (23%)
Similarity:	361/827 - (43%)	Gaps:	131/827 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DFNTVDYINQLFPNE---QSLAGIDETI-QKMQCEVSLIDDNIRSVVRGQTNTGQDGQLALCE-- 102
            :|..|:.:::|.|.:   ..|..:..:: :::|..|..:|.|        ..|.:|.:|::.|
pombe    18 EFKFVETLHELLPEDITYDDLGSLRLSLSERLQESVKKLDAN--------KKTYEDAKLSMGEKM 74

  Fly   103 --AQKVISSLFSHIIDVKTRAERTEEMVKEITRDIKQLDCAKRNLTAAITTLNHLHMLVGGIESL 165
              ....|.||...:..:::.||.|:..:.::|.:||.||.||:||..::|.|..|.|||...|.|
pombe    75 DDLNSSIVSLLQELSTLQSVAENTQSSIVQMTSEIKNLDFAKQNLATSMTMLKRLQMLVTAYEKL 139

  Fly   166 NKLIERRSYGEILNPLQAITEVNQHFQQFSDIEEIKNLSQSVDKIQVTLAQQITEDFKEAFSAK- 229
            ..|.:.:.:||.::.:||..::...|:::..:|.|.:||:|:.:.|.:..:|:.:.|:..|..:
pombe   140 RTLRQNQKFGEAISLMQATLQLLNFFKKYRSVERIASLSRSISEFQKSFYEQVFDTFQSQFKKES 204

  Fly   230 -------PSSQNQHRLGLNQLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLFHENQDIAWLD 287
                   |||...    ||:|   |:.:.:......:.:::|:...|||::..:|.||::...|:
pombe   205 GMRGGFSPSSVQY----LNEL---CRFIDIFAGDPPESVIRWYCRHQLEDFMKVFRENEEAGSLE 262

  Fly   288 KIDKRYAWLKRHLLDFEDKYGPVFPLDWEVSERITVEFCRQTREQLAQIMAKRTNEIDVRLLLFA 352
            .:.:||.|.|:.|..::..:.|:||..|:|..|:...||.:|:..|::::  :.:.:.:::.:.:
pombe   263 NLPRRYTWFKKLLQTYDQLHKPIFPPHWKVDFRLYEVFCEETKNDLSKLL--KDDRLSLQVFVAS 325

  Fly   353 INKTQAFEQLLSKRFTGVTLGAQPTDKARVLA--EPTTTDGAVGLTVFHDQIGQCFKPHLDIYIR 415
            :.:|..||..:..||...        |:|..:  ||.....       ::.:...|:||..:|..
pombe   326 LEQTLEFESFIDHRFYNT--------KSRFNSNFEPKERQA-------YNALSSVFEPHYTLYFN 375

  Fly   416 SIDRNLSELMDKFVEMSREPYKFAEAKTTVYPSSGDLFVFYKKCMVQCNQLSNEQPMYDLALVFK 480
            ...:..|.|.:.|   :.|.....:..:.|..||..||..|:|.:.|..:|:...|:..|..:|.
pombe   376 QQSQEFSILFENF---ALEKQTSTDESSQVLSSSIKLFQAYRKTLTQFVRLTRSSPLVGLKNLFI 437

  Fly   481 KYLREYASKVLEGSTPKLVPATTSSSIGKSVSLLTRDMQNLSTAAGQVFHNFLKEGDTQRFARDD 545
            |:||.|.                      .|.||  |.|..||                  .:|.
pombe   438 KWLRRYT----------------------QVELL--DYQESST------------------FKDI 460

  Fly   546 LVRICCVLTTGEYCLETVQQLEDKLKEKVTSAYVSKIDMSEEKDVFHRIISNCIQLLVQDLEAGC 610
            .:|    |.|.||...|..:||.:.:|.....:..|:..||..:|........::......|...
pombe   461 AIR----LNTAEYIYRTTIELEKRFQEISNKEFKDKMSFSEVLEVISSSRGTLLKFATGKFENVL 521

  Fly   611 EASLQAMAKVQWQHINNVGDQSAFISSLCGNFKQTVPTIRDTLASSRKYFTQFCHRFVAAFIPKF 675
            .:.|:.::|:..::|..|||||:::.....|......... ::.....:...||.|...:|..:|
pombe   522 NSDLEPLSKMDLKNIETVGDQSSYVGGAVQNMTAKASEFL-SVVDLNMFARNFCDRSCESFTRQF 585

  Fly   676 INVLYRCKLTLSDGSNNVLGCEQLLLDTHSLKTALLELPSVGSSVNRKAPTSYTKVVVKDMT--- 737
            :|.:|..| .:|:     :|.||||||.:|.|.|||:||.:      |...|.|...:..:|
pombe   586 LNAIYLAK-PISE-----VGAEQLLLDLYSFKNALLKLPDL------KQDYSITDSYINHLTIFM 638

  Fly   738 -RAEMIIKVVMTPVQPPAHFTQQVLKLLPDITIAEYQKILDMKAVKRVDQLQLIDLFKHTASAAA 801
             ..|.::|.::||..|.|.|.|..:.|:.|.::..:..:|::|.|.:.|....:..|
pombe   639 GYIETVLKTLLTPASPKAGFIQSYIFLVKDRSVTNFTVLLELKGVGKSDISSFLQQF-------- 695

  Fly   802 VSGLIEPTTGEEETQ------GAETVVATSGTTDDAETSAVPTETTT 842
             |..::.|...||:.      ...|.|..:.|.........|..:.|
pombe   696 -SDFVKKTPQLEESSPIFKYLTINTAVEQAATRSRLSLDLAPESSRT 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps53	NP_608825.2	Vps53_N	42..434	CDD:282020	97/407 (24%)
vps53	NP_593341.1	Vps53_N	16..394	CDD:282020	98/410 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	152	1.000	Domainoid score	I1087
eggNOG	1	0.900	-	-		E1_KOG2180
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6264
Inparanoid	1	1.050	241	1.000	Inparanoid score	I813
OMA	1	1.010	-	-		QHG54046
OrthoFinder	1	1.000	-	-		FOG0004449
OrthoInspector	1	1.000	-	-		oto102059
orthoMCL	1	0.900	-	-		OOG6_102035
Panther	1	1.100	-	-	LDO	PTHR12820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1657
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860