Protein Alignment Vps53 and vps-53

DIOPT Version :9

• Sequence 1: NP_608825.2
• Gene: Vps53 / 33640
• FlyBaseID: FBgn0031598
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001255027.2
• Gene: vps-53 / 176377
• WormBaseID: WBGene00011502
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 856
• Identity: 295/856 - (34%)
• Similarity: 459/856 - (53%)
• Gaps: 101/856 - (11%)

  Fly    43 PDFNTVDYINQLFPNEQSLAGIDETIQKMQCEVSLIDDNIRSVVRGQTNTGQDGQLALCEAQKVI 107
            |:.:.:..||:|||.||||..:|..|..::.|:..:|:.:..:|....|..:.|:.||..||..:
 Worm    30 PNMSLMAQINELFPTEQSLTQLDSIIASVEGEIGELDNELAYLVETNANVSERGEEALKHAQDAM 94

  Fly   108 SSLFSHIIDVKTRAERTEEMVKEITRDIKQLDCAKRNLTAAITTLNHLHMLVGGIESLNKLIERR 172
            ..|...|..::.|.:.::|:|:|:||||||||.|||||||:||||:|||:|:.|:|||...::::
 Worm    95 IELEKSIGSIRERTKSSDEIVREMTRDIKQLDIAKRNLTASITTLHHLHILLTGVESLGAWVDKK 159

  Fly   173 SYGEILNPLQAITEVNQHFQQFSDIEEIKNLSQSVDKIQVTLAQQITEDFKEAFSAKPSSQNQHR 237
            .|..|...|.||..|.|.|..:.:.::|.|||..:||::.:|..|:.:|.|.||.....|
 Worm   160 DYSSIARQLPAILNVLQLFDAYKESDQIANLSGQLDKLKASLTIQLAKDLKNAFQTGQLS----- 219

  Fly   238 LGLNQLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLFHENQDIAWLDKIDKRYAWLKRHLLD 302
               :::.|.|:|.:.|:..||:..:||||.|||.||..::.:|::.|||||:|.||.|..|.|.|
 Worm   220 ---DRITDMCRVAAALEGNVKENFVKWFIEQQLSEYVIIYADNEEGAWLDKVDDRYKWFVRKLTD 281

  Fly   303 FEDK-YGPVFPLDWEVSERITVEFCRQTREQLAQIMAKRTNEIDVRLLLFAINKTQAFEQLLSKR 366
            ||.. ...:||.||.:..|:|.|||..||:.|.:||.:|..::|.:||..||..|:.||.||:||
 Worm   282 FERAGLSNIFPADWHMGRRLTSEFCTVTRDILYRIMTRRRQDLDWKLLGHAIQHTKMFEALLTKR 346

  Fly   367 FTGVTLGAQPTDKARVLAEPTTTDGAVGLTVFHDQIGQCFKPHLDIYIRSIDRNLSELMD----K 427
            |                   ...||    ..|...|...|...||::|.:.::.|:|.:|    |
 Worm   347 F-------------------PEKDG----ISFEKAIWSVFDTFLDVFINAQEKTLNEFLDTCASK 388

  Fly   428 FVEMSREPYKFAEAKTTVYPSSGDLFVFYKKCMVQCNQLSNEQP--MYDLALVFKKYLREYASKV 490
            ......:|.:.:......:|||.|:|:..||.:.:.::||:|..  :.|:..|.:..||.||:..
 Worm   389 IRSGEEKPSRESSTHAVPFPSSADMFLLLKKVITESSKLSSEPDALIRDVIGVVRVCLRGYATSC 453

  Fly   491 LEGSTPKLVPATTSSSIGKSVSLLTRDMQNLSTAAGQVFHNFLKEGDTQRFARDDLVRICCVLTT 555
            |....|         |:|...|           .|..:|....:|....|...|....:||:|.|
 Worm   454 LVAFLP---------SLGSQQS-----------GAANLFSLIREEIAYPRLTPDQQFLVCCILAT 498

  Fly   556 GEYCLETVQQLEDKLKEKVTSAYVSKIDMSEEKDVFHRIISNCIQLLVQDLEAGCEASLQAMAKV 620
            .::|.||..||::||.:::..     :|:|:|.:.|:.|.:..:|:||||:|:.|:|:||:::||
 Worm   499 ADWCAETSIQLQEKLSQRIPG-----VDISQETEAFYSITNQSLQVLVQDVESTCDAALQSISKV 558

  Fly   621 QWQHINNVGDQSAFISSLCGNFKQTVPTIRDTLASSRKYFTQFCHRFVAAFIPKFINVLYRCKLT 685
            .|..::.|||:|.||.|:..:.:|.||.|||.|:..||||..||.:.......||:..|:||: |
 Worm   559 NWTAVDCVGDESPFIGSMRAHLRQAVPLIRDMLSDRRKYFAHFCLKLATQLAHKFVGSLFRCR-T 622

  Fly   686 LSDGSNNVLGCEQLLLDTHSLKTALLELPSVGSSVNRKAPTSYTKVVVKDMTRAEMIIKVVMTPV 750
            :|     ..|.||||||||||||.||.:||:.|.:|.|.||:|...|...:|:||||:||||..:
 Worm   623 IS-----THGAEQLLLDTHSLKTFLLSVPSIDSIINSKPPTAYVTSVNAALTKAEMILKVVMCSL 682

  Fly   751 QPPAHFTQQVLKLLPDITIAEYQKILDMKAVKRVDQLQLIDLFKHTASAAAVSGLIEPTTGEEET 815
            :....|.:|.:||||....||.||:|:||.|||.:...:::.::....|          :|.:..
 Worm   683 ETVDEFVEQYIKLLPASDAAEMQKVLEMKGVKRQEHSAVLNAYRLKIGA----------SGSDPI 737

  Fly   816 QGAETVVATSGTTDDAETSAVPTETTTATSSTPKRAFI------FSVGSFTGSADKNADGSSQTG 874
            |.:.::.:..|       .|:||..:.|:.|....|.:      .|..:.|.|.||
 Worm   738 QQSNSLTSRIG-------GALPTVGSAASVSEAFNAVVSMAADGLSDQAVTSSIDK--------- 786

  Fly   875 IRKLENLLKKR 885
            :::.|.|:|::
 Worm   787 LKRFERLVKRQ 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps53	NP_608825.2	Vps53_N	42..434	CDD:282020	145/395 (37%)
vps-53	NP_001255027.2	Vps53_N	30..390	CDD:282020	145/390 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159370
Domainoid	1	1.000	261	1.000	Domainoid score	I1056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6264
Inparanoid	1	1.050	482	1.000	Inparanoid score	I802
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54046
OrthoDB	1	1.010	-	-		D1379600at2759
OrthoFinder	1	1.000	-	-		FOG0004449
OrthoInspector	1	1.000	-	-		oto20708
orthoMCL	1	0.900	-	-		OOG6_102035
Panther	1	1.100	-	-	LDO	PTHR12820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1657
SonicParanoid	1	1.000	-	-		X4236
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940