DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17612 and AZF1

DIOPT Version :9

Sequence 1:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	619	Identity:	105/619 - (16%)
Similarity:	201/619 - (32%)	Gaps:	187/619 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PETQINDKVHLEMSINGE-DGLPEHPLYPEVQLVVKEEDALIKKKVIEENHIHNEEIIGASNIVD 108
            ||:::|     .:|:|.: :|.|             ..|.:......:.|.:.|::...:||..:
Yeast   319 PESRLN-----SLSVNNKANGDP-------------VADNVTNNMKGKSNEVDNDDGNDSSNNNN 365

  Fly   109 VEVHENHRANNDVILIQDSFAEEVILEDHPANNDVIIIQDSVAEEELPVIKEEAIEGEDLQGEYF 173
            ...:.|:..||:              :::..|||..|  :|.....:|..::.::...|...
Yeast   366 NNNNNNNNENNN--------------DNNNDNNDNSI--NSATSTNIPNQEDHSLASTDTTS--- 411

  Fly   174 IITECLEEPAIGSCRVCLEQSDNLTNIFDDAHQYGIPIATILSQYTGMPVEKGDSFSEYICVTCL 238
                       .|.:...|....|....:|...|...|:        .|::|.|      .:...
Yeast   412 -----------NSRKDLKEIEQRLRKHLNDEDNYSSAIS--------RPLDKND------VIEGS 451

  Fly   239 DVVKNAFDDLESKENTIQMYRQPKEEIIDIDSIPVKNKPVDYE------------VTGKPPHRCP 291
            :.:....|:...:.|.|:..::....:...:.:|..:.|:..:            .:||.| ..|
Yeast   452 EGLNKHIDESGMQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSGKEP-PIP 515

  Fly   292 Q-------------CPKIFLLAAKLQAH-------IRT-------HNETRTTEPPRLKCPMCPSI 329
            .             ..|:..|...:||.       :.|       .|:|....||  |..:...:
Yeast   516 DISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDGDLLFNQTMDILPP--KSELVGGV 578

  Fly   330 YMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIHIQTHEDVSQRLSRKSSHK- 393
            ...:|....     ||..:.|        ||:|.:||..::.||:|:::|          ..:|
Yeast   579 EKPKGTQNT-----RAVKKHE--------CPYCHRLFSQATHLEVHVRSH----------IGYKP 620

  Fly   394 --CAQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEESNLKSHDCAHTRFKCHKCSKFFES 456
              |..|...|:...:|:.|.::|.||:.:.|.:|...|..:.||.:|...|.:.|
Yeast   621 FVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLK---------- 675

  Fly   457 QNYLDFHFKKSHTTKGPFKC--IKCQQTFQKRNGLKEHISS------QVCVQFLRSKSPGQIFPC 513
                            ||.|  ..|.:||.:...:|.|.:.      ......|...:|.:..|
Yeast   676 ----------------PFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIP- 723

  Fly   514 PKCPKKFSIEDNYQMHHATHKKVKTVIERHNCTQCKKSYQNKKLLTKHILSHNRCVHCSMSFTSK 578
                    :|:...:.:.             .:..|.|.:..|...|.:.:....:....:..:.
Yeast   724 --------LEERQLLEYF-------------ASIYKNSNRGIKGRGKGVGTKKSTISSPENHPAS 767

  Fly   579 YLLEQHTCSQSYQLNGSRGRKNPNLNYNECEESN 612
            .:|..:|.:.:...|.|....||..|.:....||
Yeast   768 TILNPNTNANNAIANDSENNGNPEGNIDSSSNSN 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	8/58 (14%)
		C2H2 Zn finger	290..310	CDD:275368	6/46 (13%)
		C2H2 Zn finger	323..343	CDD:275370	1/19 (5%)
		zf-C2H2_8	356..438	CDD:292531	23/84 (27%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..438	CDD:275368	5/15 (33%)
		C2H2 Zn finger	447..463	CDD:275368	0/15 (0%)
		C2H2 Zn finger	476..505	CDD:275368	7/36 (19%)
		C2H2 Zn finger	513..533	CDD:275368	1/19 (5%)
		C2H2 Zn finger	545..565	CDD:275368	4/19 (21%)
		C2H2 Zn finger	568..584	CDD:275368	1/15 (7%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	88/543 (16%)
		C2H2 Zn finger	595..615	CDD:275368	8/19 (42%)
		C2H2 Zn finger	623..643	CDD:275368	5/19 (26%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		C2H2 Zn finger	679..702	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100