DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17612 and ZNF532

DIOPT Version :9

Sequence 1:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	XP_016881299.1	Gene:	ZNF532 / 55205	HGNCID:	30940	Length:	1345	Species:	Homo sapiens

Alignment Length:	717	Identity:	144/717 - (20%)
Similarity:	237/717 - (33%)	Gaps:	245/717 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 IKKKVIEENHIH--NEEIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILED--HPANNDVII 145
            :|..||....:.  :..||.|:|.:..:.         |::...|.|...::..  |.||.: ::
Human   520 VKATVISAASVQSASSAIIKAANAIQQQT---------VVVPASSLANAKLVPKTVHLANLN-LL 574

  Fly   146 IQDSVAEEELPVIKEEAIEGEDLQGEYFIITECLEEP--AIGSCRVCLEQSDNLTNIFDDAHQYG 208
            .|.:.|..||    .:.:.....|.:..||.....:|  .:...:|......::...|:
Human   575 PQGAQATSEL----RQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFN------ 629

  Fly   209 IPIATILSQYTGMPV-----------------------EKGDSF-------------SEYICVTC 237
                .:||....:||                       |.||||             |..|.|||
Human   630 ----KVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTC 690

  Fly   238 LDVVKNAFDDLESKENTIQMYRQPKEE--IIDIDSIPVKNKPVDYEV-----------------T 283
            ....||..  ..:|.:.:...|..||:  ::....:.:|..|.|..:                 .
Human   691 NHCTKNLV--FYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPV 753

  Fly   284 GKPPH----------------------------------------RCPQCPKIFLLAAKLQAHIR 308
            |...|                                        :|.:|.::|.....|..|.:
Human   754 GAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQ 818

  Fly   309 THNETRTTEPPRLKCPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLE 373
            ...:|...:    .|.:|..:...:....:|..||        :.:.||.||.|..:     ...
Human   819 QAADTSGQK----TCTICQMLLPNQCSYASHQRIH--------QHKSPYTCPECGAI-----CRS 866

  Fly   374 IHIQTHEDVSQ---RLSRKSSHKCAQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEESNL 435
            :|.|||  |::   ..:|:...:|..|..|:|||::||.|::....|..:|||:|.|:|:...:.
Human   867 VHFQTH--VTKNCLHYTRRVGFRCVHCNVVYSDVAALKSHIQGSHCEVFYKCPICPMAFKSAPST 929

  Fly   436 KSHDCAHTR------------FKCHKCSKFFESQNYLDFHFKK--SHTTKGPFKCIKCQQTFQKR 486
            .||  |:|:            :||..|...|..|..|..||.:  .:.....|||..|...:.::
Human   930 HSH--AYTQHPGIKIGEPKIIYKCSMCDTVFTLQTLLYRHFDQHIENQKVSVFKCPDCSLLYAQK 992

  Fly   487 NGLKEHISSQVCV---------------------------------------QFLRSKSPGQI-- 510
            ..:.:||.|....                                       :.|..|||..:
Human   993 QLMMDHIKSMHGTLKSIEGPPNLGINLPLSIKPATQNSANQNKEDTKSMNGKEKLEKKSPSPVKK 1057

  Fly   511 -----------FPCPKCPKKFSIEDNYQMHHATHKKVKTVIERHNCTQCKKSYQNKKLLTKHILS 564
                       :.|.:|...|...|.|..|  ..|:....:::|.|.||.||:.:...|.:
Human  1058 SMETKKVASPGWTCWECDCLFMQRDVYISH--VRKEHGKQMKKHPCRQCDKSFSSSHSLCR---- 1116

  Fly   565 HNR-----------CVHCSMS---FTSKYLLEQHTCSQSYQLNGSRGRKNPNLNYNECEESNESD 615
            |||           |.||..|   ||.:.:||:|.     ||  ..|.|:|:|. ...:.:||.:
Human  1117 HNRIKHKGIRKVYACSHCPDSRRTFTKRLMLEKHV-----QL--MHGIKDPDLK-EMTDATNEEE 1173

  Fly   616 LE 617
            .|
Human  1174 TE 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	18/94 (19%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275370	3/19 (16%)
		zf-C2H2_8	356..438	CDD:292531	27/84 (32%)
		C2H2 Zn finger	359..379	CDD:275368	5/19 (26%)
		C2H2 Zn finger	394..414	CDD:275368	9/19 (47%)
		C2H2 Zn finger	422..438	CDD:275368	5/15 (33%)
		C2H2 Zn finger	447..463	CDD:275368	5/15 (33%)
		C2H2 Zn finger	476..505	CDD:275368	6/67 (9%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..584	CDD:275368	8/18 (44%)
ZNF532	XP_016881299.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950