DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17612 and CG8319

DIOPT Version :9

Sequence 1:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	94/380 - (24%)
Similarity:	151/380 - (39%)	Gaps:	90/380 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 CRVCLEQSDNLTNIFDD-AHQY--GIPIATILSQYTGMPVEKGDSFSEYICVTCLDVVKNAFD-D 247
            ||:|...|:|:..|||| ..:|  |..:|.::.....:.::..|:..:.:|::|:...:.|:. .
  Fly     5 CRICGGASENMLGIFDDQVEEYVDGAKLAEMVKTCADVQLDPDDAMPQKMCISCVHDARTAYGFK 69

  Fly   248 LESKENTIQMY----------RQPKEEII------DIDSIPVK---NKPV--------------- 278
            ...:||..:.|          .:|.||..      |..::..|   ||.:
  Fly    70 RRCEENYKKFYLAILNGQVIKDEPNEEDFLFIENPDKGNLEAKKKLNKEIKKTHQTASRTTKSSI 134

  Fly   279 ---------------------------------DYEVTGKPPHRCPQCPKIFLLAAKLQAHIRTH 310
                                             |:.......|.|..|.:.||..|.|..|....
  Fly   135 TTSRAGRQLRSIKNQTFKCELCIKQFKRQINLLDHMKVHSNSHVCQNCEERFLFKADLDNHQCYR 199

  Fly   311 NETRTTEPPRLKCPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIH 375
            |...|.|     ||.|..::.....|::    |:..|.:|   ..|::||||.:.|.....|:.|
  Fly   200 NSNSTVE-----CPECLKVFSSTQSLDS----HKCKDMQE---RSPFQCPHCQQAFTREQNLKAH 252

  Fly   376 IQTHEDVSQRLSRKSSHKCAQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEESNLKSHDC 440
            :..|.:..|   ....|||:.|...|.:.|:||.|:..|.|||...||.|:.:|:.:..||.|..
  Fly   253 LLIHAESKQ---GNGPHKCSYCQTGFFNKSALKVHIHAHMGERPHACPFCVSNFRSKQALKVHIR 314

  Fly   441 AHT---RFKCHKCSKFFESQNYLDFHFKKSHTTKGPFKCIKCQQTFQKRNGLKEH 492
            .||   .::|..|.|.|...|.|..| ::.|:.:.|:||..|.|.|::::.||.|
  Fly   315 IHTGEKPYQCPHCPKTFSDNNNLAKH-RRRHSDERPYKCSICLQDFREKHHLKRH 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	16/61 (26%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275370	4/19 (21%)
		zf-C2H2_8	356..438	CDD:292531	29/81 (36%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..438	CDD:275368	6/15 (40%)
		C2H2 Zn finger	447..463	CDD:275368	6/15 (40%)
		C2H2 Zn finger	476..505	CDD:275368	7/17 (41%)
		C2H2 Zn finger	513..533	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	568..584	CDD:275368
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	18/73 (25%)
		COG5048	<153..368	CDD:227381	67/230 (29%)
		C2H2 Zn finger	153..173	CDD:275368	1/19 (5%)
		C2H2 Zn finger	179..196	CDD:275368	6/16 (38%)
		C2H2 Zn finger	207..227	CDD:275370	5/23 (22%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..332	CDD:290200	8/23 (35%)
		zf-C2H2	322..344	CDD:278523	7/22 (32%)
		C2H2 Zn finger	324..344	CDD:275368	7/20 (35%)
		C2H2 Zn finger	352..368	CDD:275368	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.030