DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17612 and Meics

DIOPT Version :9

Sequence 1:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	151/615 - (24%)
Similarity:	244/615 - (39%)	Gaps:	143/615 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VKRGGSLPKTLCLQCL--HMDTFGTKHKGPRPETQINDKVHLEMSINGEDGLPE--------HPL 70
            ||| ..:|:.:|..||  ..:.|..:||..:.....:..:.|:.|   ...|..        :||
  Fly    58 VKR-DEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKS---NSNLSRSHCRRGTMNPL 118

  Fly    71 YPEVQLVVKEEDAL-------------IKKKVIEENH---IHNEEIIGASNIVDVEVHENHRANN 119
            .|..  :|..||.|             :|..:.|...   .:.:|......:.::.:  |.....
  Fly   119 IPFE--IVGCEDPLDTNVTKLDANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITM--NDIKTE 179

  Fly   120 DVILIQDSFAEEVILEDHPANNDVIIIQD-------SVAEEELPVIK----EEAIEGEDLQGEYF 173
            |.:.||::| |:...|::..||.....:|       |..:::.|.|.    .:.:.|.:   :..
  Fly   180 DEVSIQETF-EDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNN---QSL 240

  Fly   174 IITECLEEPAIGSCRVCLEQSDNLTNIFDDAHQYGIPIAT--ILSQYTGMPVEKGDSFSEYICVT 236
            :.|||                             |:..:|  .|:::.....|:||:...::|
  Fly   241 LCTEC-----------------------------GVSYSTQKALARHVAKHKEQGDTQKPHLC-- 274

  Fly   237 CLDVVKNAFDDLESKENTIQMYRQPKEEIIDIDSIPVKNKPVDYEVTGKPPHRCPQCPKIFLLAA 301
              |.....|      ....|:....:..                  ||:.|.:||.|||.:....
  Fly   275 --DFCGRGF------RTNAQLTTHRRRH------------------TGERPFKCPLCPKAYTHGP 313

  Fly   302 KLQAHIRTHNETRTTEPPRLKCPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLF 366
            .|::|:.||:|.:..     |||.|...:..||.|.||  |.|.:.||      ||:||.||:.|
  Fly   314 TLKSHMHTHDEEKGH-----KCPQCDKTFYTRGNLRAH--IQRHTGER------PYKCPDCPQTF 365

  Fly   367 LYSSFLEIHIQTHEDVSQRLSRKSSHKCAQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQE 431
            ..:|.|::|.:.|::       :...||..|...|.....|..|:::|.|:|.||||.|..||.|
  Fly   366 AKNSGLKLHSRLHKE-------ERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFE 423

  Fly   432 ESNLKSHDCAHT---RFKCHKCSKFFESQNYLDFHFKKSHTTKGPFKCIKCQQTFQKRNGLKEHI 493
            :||:..|...|:   .|||.:|.:.|...::|..|. :.||.:.|:||.:|.:.|.....|.:|.
  Fly   424 KSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHL-RIHTGEKPYKCDQCGKGFSANQSLMKHT 487

  Fly   494 SSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMHHATHKKVKTVIERHNCTQCKKSYQNKKLL 558
            ...|       .:..:.|.|.:|||.:..:.:.:.|..|||........|.|..|...:..||.|
  Fly   488 LWHV-------DNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTL 545

  Fly   559 TKHILSH----NRCVHCSMSFTSKYLLEQH 584
            .|||.||    :.|..|...|.|:..|::|
  Fly   546 DKHITSHKIRPHPCPQCPEGFFSQKSLKKH 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	8/60 (13%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275370	8/19 (42%)
		zf-C2H2_8	356..438	CDD:292531	30/81 (37%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..438	CDD:275368	8/15 (53%)
		C2H2 Zn finger	447..463	CDD:275368	4/15 (27%)
		C2H2 Zn finger	476..505	CDD:275368	6/28 (21%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..584	CDD:275368	5/15 (33%)
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	10/37 (27%)
		C2H2 Zn finger	242..262	CDD:275368	6/48 (13%)
		C2H2 Zn finger	274..294	CDD:275368	4/29 (14%)
		zf-H2C2_2	287..311	CDD:290200	8/41 (20%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	9/21 (43%)
		zf-H2C2_2	342..366	CDD:290200	13/31 (42%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		COG5048	<395..583	CDD:227381	60/189 (32%)
		zf-C2H2	412..434	CDD:278523	11/21 (52%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	8/24 (33%)
		C2H2 Zn finger	442..462	CDD:275368	5/20 (25%)
		zf-H2C2_2	454..478	CDD:290200	8/24 (33%)
		C2H2 Zn finger	470..486	CDD:275368	4/15 (27%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275370	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960