DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17612 and D19B

DIOPT Version :9

Sequence 1:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	146/736 - (19%)
Similarity:	224/736 - (30%)	Gaps:	265/736 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ENVCQCCKVRPGLSVKRGGSLPKTLCLQC------LH---------------------------- 32
            :.:|.|    ..|||::....||.||..|      ||
  Fly    36 KKLCVC----TSLSVEQADGFPKNLCNVCFSKLNDLHDFQKQCVDSVQKFQDLVASNAFACQTNF 96

  Fly    33 --MDTFGTKHKGPRPETQINDKVHLEMSINGEDGLPEHPLYPEVQLVVKEEDAL-----IKKKVI 90
              :||.......|..|   .|.||.:..:|.           :::::..|||..     ::|:|
  Fly    97 DVLDTSAAVADLPGEE---EDNVHFDPLLNS-----------KIEIIENEEDVFKMLESVEKEV- 146

  Fly    91 EENHIHNEEIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILEDHPANNDVIIIQDSVAEEEL 155
            ||..:..|:..|             |.:.|     |||...   .|:..:.|..|..|    :::
  Fly   147 EEVEMEMEQPFG-------------RVSQD-----DSFESG---NDNDLDADFQISSD----DDI 186

  Fly   156 PVIKEE---AIEGEDLQGEYFIITECLEEPAIGSCRVCLEQSDNLTNIFDDAHQYGIPIATILSQ 217
            |:.:..   |..|...:|:.....:..||.:        |:|:. |:..||:
  Fly   187 PLAQRSRRGATRGSKAKGKPKSAAKRQEEES--------EESEE-TSSSDDS------------- 229

  Fly   218 YTGMPVEKGDSFSEYICVTCLDVVKNAFDDLESKENTIQMYRQPKEEIIDIDSIPVK-NKPVDYE 281
             .|.|.:|                        .|...|....:.:..:||......| .|.:.||
  Fly   230 -DGNPKDK------------------------PKRKRIPATERDRHRLIDCHICHQKFKKAIRYE 269

  Fly   282 VTGKP-----PHRC--PQCPKIFLLAAKLQAHI-RTHNETRTTEPPRLKCPM--CPSIYMKRGCL 336
            ...|.     |.:|  ..|.|.|..|..|:.|: ..|.||....|    |..  |...:.:...|
  Fly   270 EHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHP----CTYEGCNKSFARPVLL 330

  Fly   337 EAHMWIHRASDERESELEPPYR---CPHCPKLFLYSSFLEIHIQTHEDVSQRLSRKSSHKCAQCA 398
            ..||       :|..:::.|.|   |..|.|:|...:.|:.|:..|      ...:....|..|.
  Fly   331 SFHM-------KRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKH------TGEELPFACEICG 382

  Fly   399 DVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEESNLKSHDCAHT---RFKCHKCSKFFESQNYL 460
            ..|...|.|:||:..|||.:...||.|.:..........|...||   :::|.:|.....::..|
  Fly   383 KRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQAL 447

  Fly   461 DFHFKKSHTTKGPFKCIKCQQTFQKRNGLKEHISSQVCVQFLRSKSPGQIF-------------- 511
            ..|.|..|..:..|.|..|.:||.|.:..|.|..|....:....|..|::|
  Fly   448 ANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHE 512

  Fly   512 ------------------------------------------------------------P---- 512
                                                                        |
  Fly   513 KRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNF 577

  Fly   513 --------CPKCPKKFSIEDNYQMHH-ATHKKVKTVIERHNCTQCKKSYQNKKLLTKHILSHN-- 566
                    ||.|.|.|:...|.::|: ..|:|||...    |..|.|.:..|:.|..|...|.
  Fly   578 TKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFC----CRFCPKRFAKKQYLRHHEYIHTGE 638

  Fly   567 ---RCVHCSMSFTSKYLLEQH 584
               .|..|...|..:.:|:.|
  Fly   639 KPYECKVCGKHFRQEQVLKTH 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	8/58 (14%)
		C2H2 Zn finger	290..310	CDD:275368	7/22 (32%)
		C2H2 Zn finger	323..343	CDD:275370	5/21 (24%)
		zf-C2H2_8	356..438	CDD:292531	22/84 (26%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		C2H2 Zn finger	422..438	CDD:275368	3/15 (20%)
		C2H2 Zn finger	447..463	CDD:275368	3/15 (20%)
		C2H2 Zn finger	476..505	CDD:275368	8/28 (29%)
		C2H2 Zn finger	513..533	CDD:275368	7/20 (35%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..584	CDD:275368	4/15 (27%)
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	12/50 (24%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	16/62 (26%)
		C2H2 Zn finger	318..338	CDD:275368	5/26 (19%)
		COG5048	<347..512	CDD:227381	41/170 (24%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	3/19 (16%)
		C2H2 Zn finger	586..607	CDD:275368	7/20 (35%)
		C2H2 Zn finger	615..635	CDD:275368	6/19 (32%)
		zf-H2C2_2	627..652	CDD:290200	6/24 (25%)
		C2H2 Zn finger	643..663	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930