Protein Alignment Traf4 and TRAF3

DIOPT Version :9

• Sequence 1: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_003291.2
• Gene: TRAF3 / 7187
• HGNCID: 12033
• Length: 568
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 144/576 - (25%)
• Similarity: 219/576 - (38%)
• Gaps: 172/576 - (29%)

  Fly    67 SSHSSPTPGNNNNNMPITELEQIIYPG-----PDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHL 126
            ||....:||....|.|: :|......|     |:........|..:..|..|:        |.||
Human     3 SSKKMDSPGALQTNPPL-KLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCE--------KCHL 58

  Fly   127 NACKHDATQCPN----------------KCGAQIPRIMMTDHLQYTCTMRRTRC--EFCQSEFSG 173
            ..|....|:|.:                ||.|....|:.....:..|..|....  .:|::|..|
Human    59 VLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRG 123

  Fly   174 AG--------LEEHNGSCGQEPVYC-EAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADT 229
            ..        |......|..|.:.| ...|.:::||..:..|..|.|..|...|:||:.:.....
Human   124 CAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIA 188

  Fly   230 LPLHA-AQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFKGPRQMLEAHL 293
            |..|. ..||...::||.:|....:.|.||.||| .||.:...:||||..||.|:|..|.::||.
Human   189 LQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHL-SECVNAPSTCSFKRYGCVFQGTNQQIKAHE 252

  Fly   294 ESNAAAHLSLM----------VAL----SSRQGQQIQML-------------------------- 318
            .|:|..|::|:          |:|    |..:.:.||.|
Human   253 ASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKIL 317

  Fly   319 ---------------------------------KSAVSKL------------------------- 325
                                             ||:|..|
Human   318 HLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLE 382

  Fly   326 ----------------------------SINYTGTLLWKITDWSAKMAEARGKDGLELVSPPFYT 362
                                        :.:|.|.|:|||.|:..:..||.....|.|.|.||||
Human   383 SQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYT 447

  Fly   363 SQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAE 427
            ..:|||:.|.::|||:|.|:.||:|::..::.|||||||.|||...:|..|.:||  |.:..:.:
Human   448 GYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQG--SSRRHLGD 510

  Fly   428 SFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHSRPFIKGDTVFLRVKVDPSKI 483
            :|.|||...:|::|:.|.: :..|.|.|::..:|.:..:||.||:|::|.||.|.:
Human   511 AFKPDPNSSSFKKPTGEMN-IASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	24/123 (20%)
		zf-TRAF	233..292	CDD:424248	23/59 (39%)
		MATH_TRAF4	331..479	CDD:239750	59/147 (40%)
TRAF3	NP_003291.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		7/25 (28%)
		zf-C3HC4	56..91	CDD:278524	7/34 (21%)
		zf-TRAF	136..192	CDD:280357	14/55 (25%)
		zf-TRAF	197..247	CDD:280357	21/50 (42%)
		BBP1_C	<263..>321	CDD:291921	6/57 (11%)
		Spc29	<307..>366	CDD:293687	4/58 (7%)
		MATH_TRAF3	378..563	CDD:239746	62/187 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950