Protein Alignment Traf4 and TRAF2

DIOPT Version :10

• Sequence 1: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: XP_047279784.1
• Gene: TRAF2 / 7186
• HGNCID: 12032
• Length: 533
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 118/478 - (24%)
• Similarity: 187/478 - (39%)
• Gaps: 122/478 - (25%)

  Fly    86 LEQIIYPGPDPKHIMGSLVFCIH---HKQGCKWSDELRKLKGHLNACKHDATQCPNKCGAQIPRI 147
            |..|:..||.      :...|:|   :::|....:.......  ||.:.:....|..|.:.
Human    90 LASILSSGPQ------NCAACVHEGIYEEGISILESSSAFPD--NAARREVESLPAVCPSD---- 142

  Fly   148 MMTDHLQYTCTMRRTRCEF--CQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKD 210
                    .||.:.|..|:  |           |.|.|......|.| |...:..|....|...:
Human   143 --------GCTWKGTLKEYESC-----------HEGRCPLMLTECPA-CKGLVRLGEKERHLEHE 187

  Fly   211 CAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSF 275
            |.:|...|.||:.......:..|...||:.||.| ..|....|||.:.:.|:: .|....|.|.|
Human   188 CPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTC-DGCGKKKIPREKFQDHVK-TCGKCRVPCRF 250

  Fly   276 KEAGC--RFKGPRQM------LEAHL----------------ESNAAAHL--------------- 301
            ...||  ..:|.:|.      |..||                :|:|.:.|
Human   251 HAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFE 315

  Fly   302 -------------SLMVALSSRQGQ----QIQMLKSAVSKL----------------------SI 327
                         ::.....|||.:    :|:.|.|.|.:|                      :.
Human   316 NIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEAS 380

  Fly   328 NYTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKV 392
            .|.|..:|||:|::.|..||.......:.||.||||:||||:...::|||:|.|..||:|::..|
Human   381 TYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVV 445

  Fly   393 LPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFIS 457
            :.|..||||:|||:..:|..|.:   |:.:..|.::|.||.|..:||||.|:.: :..|.|.|..
Human   446 MKGPNDALLRWPFNQKVTLMLLD---QNNREHVIDAFRPDVTSSSFQRPVNDMN-IASGCPLFCP 506

  Fly   458 HELLHSR-PFIKGDTVFLRVKVD 479
            ...:.:: .:::.|.:|::..||
Human   507 VSKMEAKNSYVRDDAIFIKAIVD 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	17/98 (17%)
		zf-TRAF	233..292	CDD:280357	20/66 (30%)
		MATH_TRAF4	331..479	CDD:239750	53/148 (36%)
TRAF2	XP_047279784.1	rad18	60..>189	CDD:273165	24/130 (18%)
		RING-HC_TRAF2	63..105	CDD:438301	4/20 (20%)
		zf-TRAF	210..267	CDD:280357	19/58 (33%)
		TRAF_BIRC3_bd	299..362	CDD:465226	9/62 (15%)
		MATH_TRAF2	366..529	CDD:239747	54/166 (33%)