Protein Alignment Traf4 and TRAF1

DIOPT Version :10

• Sequence 1: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_005649.1
• Gene: TRAF1 / 7185
• HGNCID: 12031
• Length: 416
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 127/475 - (26%)
• Similarity: 190/475 - (40%)
• Gaps: 121/475 - (25%)

  Fly    66 SSSHSSPTPGNNNNNMPITELEQIIYPGPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACK 130
            |||.|||.|..:.|..|......:.....:|:      ..|.   .|| .|:..|..:..:
Human     3 SSSGSSPRPAPDENEFPFGCPPTVCQDPKEPR------ALCC---AGC-LSENPRNGEDQI---- 53

  Fly   131 HDATQCPNKCGAQIPRIMMTDHLQYTCTMRRTRCEFCQS----EFSGAG---------LEEHN-- 180
                 ||...|..:..|.....|:   |..:...|..::    .|:|.|         ::||.
Human    54 -----CPKCRGEDLQSISPGSRLR---TQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVT 110

  Fly   181 ----------GSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAA 235
                      |...|    .:|:.|..:..|.|.|                  |.:...|.|.||
Human   111 SQTSHLNLLLGFMKQ----WKARLGCGLESGPMAL------------------EQNLSDLQLQAA 153

  Fly   236 ---------QCPRAPLACPQRCDAGPIPR-------GELEAHLRDECQSLAVSCSFKEAGCRFKG 284
                     .|.|||  |.:..:...:..       .|||..||.....:||.....||
Human   154 VEVAGDLEVDCYRAP--CSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEA------ 210

  Fly   285 PRQMLEAHLESNAAAH---------LSL---MVALSSRQGQQIQMLKSAVSKLSI----NYTGTL 333
                  :||....:.|         |||   :|.|.....|:.|.|......|.:    ::.||.
Human   211 ------SHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTF 269

  Fly   334 LWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYD 398
            |||||:.:.:..|:.....:.|.||.|||::|||||...::|||:|.|:.||:|::|.::.||||
Human   270 LWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYD 334

  Fly   399 ALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHS 463
            |||.|||.:.:||.|.:   |:.:....::|.||.:..:||||.:|.: :..|.|.|.....|.|
Human   335 ALLPWPFRNKVTFMLLD---QNNREHAIDAFRPDLSSASFQRPQSETN-VASGCPLFFPLSKLQS 395

  Fly   464 --RPFIKGDTVFLRVKVDPS 481
              ..::|.||:||:..|:.|
Human   396 PKHAYVKDDTMFLKCIVETS 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	22/121 (18%)
		zf-TRAF	233..292	CDD:280357	16/74 (22%)
		MATH_TRAF4	331..479	CDD:239750	60/149 (40%)
TRAF1	NP_005649.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		9/20 (45%)
		TRAF_BIRC3_bd	182..245	CDD:465226	17/74 (23%)
		MATH_TRAF1	267..413	CDD:239748	60/149 (40%)