DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf4 and Traf4

DIOPT Version :9

Sequence 1:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001100487.1	Gene:	Traf4 / 303285	RGDID:	1306708	Length:	470	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	185/406 - (45%)
Similarity:	262/406 - (64%)	Gaps:	11/406 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IYPGPDPK-HIMGSLVFCIHHKQGCKWSDELRKLKGHLNACKHDATQCPNKCGAQIPRIMMTDHL 153
            |||.|:.: .::|..:.|||.::||:||..||.|:||||.|..:...|||:|.|::.|..:..||
  Rat    66 IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLPAHL 130

  Fly   154 QYTCTMRRTRCEFCQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRC 218
            |:.|..||.:||||..:|||...|.|.|.|.||.||||.|||.|::|..:..|.:.:|.||.:.|
  Rat   131 QHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPC 195

  Fly   219 AHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFK 283
            |:|.:||..||:..|..||||.|:.||.:|..|.:.|.:|..||:|.|.:..|.|.|||:||:.:
  Rat   196 AYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHR 260

  Fly   284 GPRQMLEAHLESNAAAHLSLMVALSSRQGQQIQMLKSAVSKLSINYTGTLLWKITDWSAKMAEAR 348
            .|:..:..|:|.:...||::|.||.|||.|::|.|:..:.:||:...|.|:|||..:..::.||:
  Rat   261 CPKLAMGRHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAK 325

  Fly   349 GKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTL 413
            .|..||..||.|||.:||||||.|.||||||.||.||:|:||:||||.:|.||:|||:..:||:|
  Rat   326 AKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSL 390

  Fly   414 FEQ---GAQSGQGGVAESFVPDPTWENFQRP-----SNEPDQLGFGFPRFISHELLHSRPFIKGD 470
            .:|   |....| .|.|:|.|||.|:|||:|     |.:...||||:|:||||:.:..|.:::.|
  Rat   391 LDQSDPGLAKPQ-HVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDD 454

  Fly   471 TVFLRVKVD-PSKIVA 485
            .||:|..|: |.||::
  Rat   455 AVFIRASVELPRKILS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	46/96 (48%)
		zf-TRAF	233..292	CDD:424248	24/58 (41%)
		MATH_TRAF4	331..479	CDD:239750	77/155 (50%)
Traf4	NP_001100487.1	mRING-HC-C3HC3D_TRAF4	15..59	CDD:319555
		zf-TRAF	102..156	CDD:280357	23/53 (43%)
		zf-TRAF	210..269	CDD:280357	23/58 (40%)
		MATH_TRAF4	308..463	CDD:239750	80/163 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354217
Domainoid	1	1.000	193	1.000	Domainoid score	I3110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3173
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1865
OMA	1	1.010	-	-		QHG48494
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004698
OrthoInspector	1	1.000	-	-		oto96350
orthoMCL	1	0.900	-	-		OOG6_100533
Panther	1	1.100	-	-	LDO	PTHR10131
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4401
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900