DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf4 and Traf5

DIOPT Version :9

Sequence 1:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_035763.2	Gene:	Traf5 / 22033	MGIID:	107548	Length:	558	Species:	Mus musculus

Alignment Length:	500	Identity:	130/500 - (26%)
Similarity:	208/500 - (41%)	Gaps:	123/500 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 NNMPITELE-QIIYP------GPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACKHDATQC 136
            |::||..:: ::|.|      ....:.::...|:| .:..||.....|.:.:.||..|...|..|
Mouse    76 NSVPICPVDKEVIKPQEVFKDNCCKREVLNLHVYC-KNAPGCNARIILGRFQDHLQHCSFQAVPC 139

  Fly   137 PNK-CGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEH-NGSCGQEPVYCEAKCGQRIL 199
            ||: |...:.|..:.:||...|..|..:|.:|:.:.....|::| ..||...||.|..:|.|.|.
Mouse   140 PNESCREAMLRKDVKEHLSAYCRFREEKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIP 204

  Fly   200 RGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPI---PRGELEAH 261
            |.|:..|        |..|...:::            ||.....|..:...|.:   .|..|:.|
Mouse   205 RARVNEH--------LTVCPEAEQD------------CPFKHYGCTVKGKRGNLLEHERAALQDH 249

  Fly   262 ----------LRDECQSLAVSCSFKEAGCR-------------------------FKGPRQMLEA 291
                      |......|..|...||:..:                         |....|.|.:
Mouse   250 MLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTS 314

  Fly   292 HLESNA--AAHLSLMVALSSRQ--------------------------GQQIQMLKSAVSK---- 324
            |.:.:|  .|.:..::.:.::|                          .|::.:|:...||
Mouse   315 HTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAH 379

  Fly   325 -------LSIN-----------YTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQA 371
                   |:.|           |:|.|:||:||:..|..||.....:.:.|.|||||:.||:|.|
Mouse   380 INIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCA 444

  Fly   372 SMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWE 436
            ..:|||:|.|:.||:|:|..|:.||:|:||:|||...:|..|.:|..:...  :.|:|..||...
Mouse   445 RAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNH--IVETFKADPNSS 507

  Fly   437 NFQRPSNEPDQLGFGFPRFISHELLHS--RPFIKGDTVFLRVKVD 479
            :|:||..|.: :..|.|||:||..|.:  ..:||.||:||:|.||
Mouse   508 SFKRPDGEMN-IASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	30/98 (31%)
		zf-TRAF	233..292	CDD:424248	15/96 (16%)
		MATH_TRAF4	331..479	CDD:239750	62/149 (42%)
Traf5	NP_035763.2	mRING-HC-C3HC3D_TRAF5	43..85	CDD:319556	3/8 (38%)
		zf-TRAF	128..183	CDD:280357	16/54 (30%)
		zf-TRAF	185..241	CDD:424248	17/75 (23%)
		Smc	<237..>419	CDD:224117	29/181 (16%)
		Interaction with EIF2AK2/PKR. /evidence=ECO:0000250	345..558		70/209 (33%)
		MATH_TRAF5	404..551	CDD:239749	62/149 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48494
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920