Protein Alignment Traf4 and Traf5

DIOPT Version :10

• Sequence 1: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_035763.2
• Gene: Traf5 / 22033
• MGIID: 107548
• Length: 558
• Species: Mus musculus
• Alignment Length: 500
• Identity: 130/500 - (26%)
• Similarity: 208/500 - (41%)
• Gaps: 123/500 - (24%)

  Fly    79 NNMPITELE-QIIYP------GPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACKHDATQC 136
            |::||..:: ::|.|      ....:.::...|:| .:..||.....|.:.:.||..|...|..|
Mouse    76 NSVPICPVDKEVIKPQEVFKDNCCKREVLNLHVYC-KNAPGCNARIILGRFQDHLQHCSFQAVPC 139

  Fly   137 PNK-CGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEH-NGSCGQEPVYCEAKCGQRIL 199
            ||: |...:.|..:.:||...|..|..:|.:|:.:.....|::| ..||...||.|..:|.|.|.
Mouse   140 PNESCREAMLRKDVKEHLSAYCRFREEKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIP 204

  Fly   200 RGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPI---PRGELEAH 261
            |.|:..|        |..|...:::            ||.....|..:...|.:   .|..|:.|
Mouse   205 RARVNEH--------LTVCPEAEQD------------CPFKHYGCTVKGKRGNLLEHERAALQDH 249

  Fly   262 ----------LRDECQSLAVSCSFKEAGCR-------------------------FKGPRQMLEA 291
                      |......|..|...||:..:                         |....|.|.:
Mouse   250 MLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTS 314

  Fly   292 HLESNA--AAHLSLMVALSSRQ--------------------------GQQIQMLKSAVSK---- 324
            |.:.:|  .|.:..::.:.::|                          .|::.:|:...||
Mouse   315 HTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAH 379

  Fly   325 -------LSIN-----------YTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQA 371
                   |:.|           |:|.|:||:||:..|..||.....:.:.|.|||||:.||:|.|
Mouse   380 INIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCA 444

  Fly   372 SMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWE 436
            ..:|||:|.|:.||:|:|..|:.||:|:||:|||...:|..|.:|..:...  :.|:|..||...
Mouse   445 RAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNH--IVETFKADPNSS 507

  Fly   437 NFQRPSNEPDQLGFGFPRFISHELLHS--RPFIKGDTVFLRVKVD 479
            :|:||..|.: :..|.|||:||..|.:  ..:||.||:||:|.||
Mouse   508 SFKRPDGEMN-IASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVD 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	30/98 (31%)
		zf-TRAF	233..292	CDD:280357	15/96 (16%)
		MATH_TRAF4	331..479	CDD:239750	62/149 (42%)
Traf5	NP_035763.2	mRING-HC-C3HC3D_TRAF5	39..94	CDD:438304	5/17 (29%)
		zf-TRAF	128..183	CDD:280357	16/54 (30%)
		zf-TRAF	185..241	CDD:280357	17/75 (23%)
		HemX	255..>366	CDD:442199	13/110 (12%)
		Interaction with EIF2AK2/PKR. /evidence=ECO:0000250	345..558		70/209 (33%)
		MATH_TRAF5	404..551	CDD:239749	62/149 (42%)