Protein Alignment Traf4 and Traf2

DIOPT Version :9

• Sequence 1: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001277342.1
• Gene: Traf2 / 22030
• MGIID: 101835
• Length: 508
• Species: Mus musculus
• Alignment Length: 517
• Identity: 120/517 - (23%)
• Similarity: 188/517 - (36%)
• Gaps: 162/517 - (31%)

  Fly    44 TTSGSGNCATSRSSSSTVSSSHSSSHSSPTPGNNNNNMPITELEQIIYPGPDPKHIMGSLVFCIH 108
            ::||..|||.................||..|    :|....|:|.:  |...|
Mouse    69 SSSGPQNCAACVYEGLYEEGISILESSSAFP----DNAARREVESL--PAVCP------------ 115

  Fly   109 HKQGCKWSDELRKLKG-HLNACKHDATQCPNKCGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFS 172
             ..||.|...|::.:. |...|....|:||...|  :.|:...:|
Mouse   116 -NDGCTWKGTLKEYESCHEGLCPFLLTECPACKG--LVRLSEKEH-------------------- 157

  Fly   173 GAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQC 237
                                             |..::|.||...|.||:...|...|.:|...|
Mouse   158 ---------------------------------HTEQECPKRSLSCQHCRAPCSHVDLEVHYEVC 189

  Fly   238 PRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFKGPRQMLEAHLESNAAAHLS 302
            |:.||.| ..|....|||...:.|:| .|....|.|.|...||......:.|:.|.......||:
Mouse   190 PKFPLTC-DGCGKKKIPRETFQDHVR-ACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLA 252

  Fly   303 LMV-------------------------------------------------------------- 305
            |::
Mouse   253 LLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLD 317

  Fly   306 -----ALSSRQGQQIQM-----------LKSAVSKLSIN-YTGTLLWKITDWSAKMAEARGKDGL 353
                 |||::. ||::.           |:..||:|.:: |.|..:|||:|::.|..||......
Mouse   318 QDKIEALSNKV-QQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTP 381

  Fly   354 ELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGA 418
            .:.||.||||:||||:...::|||:|.|..||:|::..|:.|..||||:|||:..:|..|.:
Mouse   382 AIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD--- 443

  Fly   419 QSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHSR-PFIKGDTVFLRVKVD 479
            .:.:..|.::|.||.|..:||||.::.: :..|.|.|.....:.:: .:::.|.:|::..||
Mouse   444 HNNREHVIDAFRPDVTSSSFQRPVSDMN-IASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVD 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	12/97 (12%)
		zf-TRAF	233..292	CDD:424248	19/58 (33%)
		MATH_TRAF4	331..479	CDD:239750	51/148 (34%)
Traf2	NP_001277342.1	zf-C3HC4	34..79	CDD:278524	5/9 (56%)
		zf-TRAF	185..242	CDD:280357	19/58 (33%)
		TRAF_BIRC3_bd	274..336	CDD:293278	5/62 (8%)
		Important for interaction with BIRC2 and BIRC3	290..300		0/9 (0%)
		MATH_TRAF2	341..504	CDD:239747	56/166 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950