DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf4 and trf-2

DIOPT Version :9

Sequence 1:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_491534.2	Gene:	trf-2 / 172151	WormBaseID:	WBGene00022454	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	293	Identity:	70/293 - (23%)
Similarity:	118/293 - (40%)	Gaps:	55/293 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 PLHAAQCPRAPLACPQRCDAGPIPRG-------ELEAHLRDE----CQSLA----VSCSFKEAGC 280
            |:.:|..|..||..|....|...||.       .:..|:..|    .:|:.    :.|.|||.||
Worm    29 PIKSASNPPTPLDSPFMAGAINRPRTSTRSVGVSIPIHVEGEEPTAPKSIVPDNWIDCPFKEHGC 93

  Fly   281 RFKGPRQMLEAHLESNAAAHLSLM--------VALSSRQG----------QQIQMLKSAVSKLSI 327
            ..||....::.|:..:...||.|:        ..::.:|.          |.:.:.:||..|...
Worm    94 HKKGENSEVKRHVRDDRNLHLVLLCQSLNPIRTKINIQQSAYVDKYVGMLQYMSIAESAFEKYGS 158

  Fly   328 NYTGTLLWKITDWSAKMAEA-RGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIK 391
            .:|    ::|......:.:| :.|....:.|.|||:..||||:.|.....|:|.....:.||::.
Worm   159 QHT----FRIPKIGLTVVKATKNKSHRSIYSQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVC 219

  Fly   392 VLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWEN----FQRPSNEPDQL---G 449
            ::.||:|.:|:|||...:||::....        .:..:....:.|    .|.....|:.|   .
Worm   220 LMKGEWDDILEWPFRCDVTFSILSDD--------KKELLTKTIYVNEMPEIQEFLERPEGLRNGT 276

  Fly   450 FGFPRFISHELLHSRPFIKGDTVFLRVKVDPSK 482
            |||..|:  .|.....|.....:|:::||..||
Worm   277 FGFQNFL--PLAKVTEFAADGDIFIQIKVLLSK 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635
		zf-TRAF	233..292	CDD:424248	19/73 (26%)
		MATH_TRAF4	331..479	CDD:239750	37/155 (24%)
trf-2	NP_491534.2	MATH_TRAF_C	158..304	CDD:238168	38/159 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I5900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	1	1.000	-	-		FOG0004698
OrthoInspector	1	1.000	-	-		otm14558
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950