DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf4 and RNF151

DIOPT Version :9

Sequence 1:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_005255186.1	Gene:	RNF151 / 146310	HGNCID:	23235	Length:	254	Species:	Homo sapiens

Alignment Length:	215	Identity:	53/215 - (24%)
Similarity:	78/215 - (36%)	Gaps:	78/215 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VFCIHHKQGCKWSDELRKLKGHLNACKHDATQCPNK-CGAQIPRIMMTDHLQYTCTMRRTRCEFC 167
            |.|.:...||..:..|...|||.::|..:.|.|||: |.:|:||..:.:|.|:           |
Human    90 VKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQVPRGTLAEHRQH-----------C 143

  Fly   168 QSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPL 232
            |.     |.::.          |...||..:           |.|:|.|.  :|.||       |
Human   144 QQ-----GSQQR----------CPLGCGATL-----------DPAERARH--NCYRE-------L 173

  Fly   233 HAA----QCPRAPLACPQRCDAGPIPRGELEAHLR-----DECQSLA------VSCSFKEAGCRF 282
            |.|    |..|.||               |.:.||     |:..|:.      :|...:|.....
Human   174 HNAWSVRQERRRPL---------------LLSLLRRVRWLDQATSVVRRELAELSNFLEEDTALL 223

  Fly   283 KG-PRQMLEAHLESNAAAHL 301
            :| |::..||..|.|..|.:
Human   224 EGAPQEEAEAAPEGNVGAEV 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	23/97 (24%)
		zf-TRAF	233..292	CDD:424248	16/74 (22%)
		MATH_TRAF4	331..479	CDD:239750
RNF151	XP_005255186.1	RING	29..70	CDD:238093
RNF151	XP_005255186.1	Sina	92..>139	CDD:302762	16/46 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010