Protein Alignment Atet and ABCG2

DIOPT Version :10

• Sequence 1: NP_523471.2
• Gene: Atet / 33636
• FlyBaseID: FBgn0020762
• Length: 832
• Species: Drosophila melanogaster
• Sequence 2: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 213/802 - (26%)
• Similarity: 369/802 - (46%)
• Gaps: 178/802 - (22%)

  Fly    46 TSGNMSLSTLSTGSGNPNPNPNASTNSRQEPVPLLSQLKLTNDLKQNSHG---SQNNLCNGGLGS 107
            :|.|:.: .:....||.|..|..:                :||||..:.|   |.:|:|.
Human     2 SSSNVEV-FIPVSQGNTNGFPATA----------------SNDLKAFTEGAVLSFHNICY----- 44

  Fly   108 NNHALAPKVANNSGGSPNGQKKGTIALSHLPQRPPVDIEFCDISYSVTDSHRRGFKTILKSVSGK 172
                   :|...||              .||.|.||:                  |.||.:::|.
Human    45 -------RVKLKSG--------------FLPCRKPVE------------------KEILSNINGI 70

  Fly   173 FRNGEITAIMGPSGAGKSTLMNILAGYK-TAQLSGSVLINSKERNLRRFRKLSCYIMQDDVLIAN 236
            .:.| :.||:||:|.|||:|:::||..| .:.|||.||||...|. ..|:..|.|::||||::..
Human    71 MKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP-ANFKCNSGYVVQDDVVMGT 133

  Fly   237 LTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNT-----LTCNLSGGQRKRLSIAL 296
            |||||.:..:|.|:|...|.::.|...:..:::.:||.:..::     ....:|||:|||.||.:
Human   134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGM 198

  Fly   297 ELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQ 361
            ||:.:|.::|.||||:||||||...::.||:.:::.||||:.:||||...:|:.||.|.|||.|:
Human   199 ELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGR 263

  Fly   362 CVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVL 426
            .::.|..:..:.|..|.||.|.:|:||||:.|::.:|:             |.|......:|:..
Human   264 LMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGD-------------STAVALNREEDFKA 315

  Fly   427 TLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQNS 491
            |        :||                   :|..:|:.|     ::..||:
Human   316 T--------EII-------------------EPSKQDKPL-----IEKLAEI------------- 335

  Fly   492 DCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTGFPTS 556
               .||        |..:..:|...:.:    |||             ..:..:|:..:..:.||
Human   336 ---YVN--------SSFYKETKAELHQL----SGG-------------EKKKKITVFKEISYTTS 372

  Fly   557 GWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASKIMSNAGCIFFVSLFT 621
            ...|...:.||||:.:|.:...:..::...|::|.:||.||:.:.|:::.|.:.||.:||::...
Human   373 FCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQ 437

  Fly   622 TFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIAD-MPFQIVFSSVYVLVVYYLTSQPM 685
            .|:::....| |..|..:|:.|:::.:|.:.:::..|.::| :|.:::.|.::..:||::.....
Human   438 CFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKP 501

  Fly   686 ELER--VSMFVLICVLNSLVAQSLGLLIGAGMN-IETGVFLGPVTTIPTILFSGFFVNFDTIPGY 747
            :.:.  |.||.|:.|..|  |.|:.|.|.||.: :.....|..:..:..::|||..||..||..:
Human   502 KADAFFVMMFTLMMVAYS--ASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASW 564

  Fly   748 LQWVTYVSYVRYGFEGAMVAIY-------GMD-RAKMQCNQMYCHYRVPKKFLEEMSMDNALF-- 802
            |.|:.|.|..||||.......:       |:: .....||...|   ..:::|.:..:|.:.:
Human   565 LSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATC---TGEEYLVKQGIDLSPWGL 626

  Fly   803 WVDAVALIGIFFALRIIAYFVL 824
            |.:.|||..:......|||..|
Human   627 WKNHVALACMIVIFLTIAYLKL 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_523471.2	3a01204	137..825	CDD:273361	196/708 (28%)
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	194/706 (27%)