DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and PDR11

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_012252.1	Gene:	PDR11 / 854802	SGDID:	S000001275	Length:	1411	Species:	Saccharomyces cerevisiae

Alignment Length:	841	Identity:	198/841 - (23%)
Similarity:	321/841 - (38%)	Gaps:	222/841 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PLLSQ---LKLTNDLKQ-----NSHGSQNNLCNGGLGSNNHALAPK--VANNSGGSP-------- 124
            ||.::   |:..|.||:     ||....|   ...:.:|:....||  :||.|..|.
Yeast   659 PLFTRENLLRWNNYLKRYCPFLNSQKKNN---KSAITNNDGVCTPKTPIANFSTSSSSVPSVSHQ 720

  Fly   125 --------------NGQKKGTIAL---SHLPQRPPVDIEFCDISYSVTDSHRRGFKTILKSVSGK 172
                          |...|.::|:   .|:       |.:.:|:|::.|      |.::...||.
Yeast   721 YDTDYNIKHPDETVNNHTKESVAMETQKHV-------ISWKNINYTIGD------KKLINDASGY 772

  Fly   173 FRNGEITAIMGPSGAGKSTLMNILA-GYKTAQLSGSVLINSKE-RNLRRFRKLSCYIMQDDVLIA 235
            ..:| :||:||.|||||:||:|:|: ..::..::|.:||:.:. .|:..||:...::.|.||.:.
Yeast   773 ISSG-LTALMGESGAGKTTLLNVLSQRTESGVVTGELLIDGQPLTNIDAFRRSIGFVQQQDVHLE 836

  Fly   236 NLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNTLTCNLSGGQRKRLSIALELVN 300
            .|||||::.::..|: |.....|  :.||..:|.....|     |..:||..|||.|||.:|||.
Yeast   837 LLTVRESLEISCVLR-GDGDRDY--LGVVSNLLRLPSEK-----LVADLSPTQRKLLSIGVELVT 893

  Fly   301 NPP-VMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQ-GQCV 363
            .|. ::|.||||||||:.....::..|:.|:..|:.|:|||||||..:...||::|||.: |:||
Yeast   894 KPSLLLFLDEPTSGLDAEAALTIVQFLKKLSMQGQAILCTIHQPSKSVISYFDNIYLLKRGGECV 958

  Fly   364 YEGRVKGLVPYLSS----LGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDY 424
            |.|.:.....|..:    |.:: ....||||:|::|.
Yeast   959 YFGSLPNACDYFVAHDRRLTFD-REMDNPADFVIDVV---------------------------- 994

  Fly   425 VLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQ 489
                             |||:.|.           |::|.:...|..:|:|....      :||
Yeast   995 -----------------GSGSTNI-----------PMDDAEKPTSSKIDEPVSYH------KQS- 1024

  Fly   490 NSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTG-- 552
                           ||.:::.          .....|..|......||...|:     .|:|
Yeast  1025 ---------------DSINWAE----------LWQSSPEKVRVADDLLLLEEEA-----RKSGVD 1059

  Fly   553 FPTSGWT------QFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASKIMSNA 611
            |.||.|:      |..::.||.:....||......:...:...|..||..::...:..:.:..
Yeast  1060 FTTSVWSPPSYMEQIKLITKRQYICTKRDMTYVFAKYALNAGAGLFIGFSFWRTKHNINGLQD-- 1122

  Fly   612 GCIFFVSLFTTFTAMMPTI-----LTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFSS 671
             .||.  .|.......|.|     ....::.....||..:..|.......|:||.::|..|..|:
Yeast  1123 -AIFL--CFMMLCVSSPLINQVQDKALQSKEVYIAREARSNTYHWTVLLIAQTIVELPLAISSST 1184

  Fly   672 VYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGL-LIGAGMNIET-GVFLGPVTTIPTILF 734
            ::.|..|:............:|.|..:|.|:...|.|| |:.:..:::| .||:..:.:. |..|
Yeast  1185 LFFLCCYFCCGFETSARVAGVFYLNYILFSMYYLSFGLWLLYSAPDLQTAAVFVAFLYSF-TASF 1248

  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDR-------------------------- 773
            .|....:...|.:..::..||...|..| ..|::...||
Yeast  1249 CGVMQPYSLFPRFWTFMYRVSPYTYFIE-TFVSLLLHDREVNCSTSEMVPSQPVMGQTCGQFMKP 1312

  Fly   774 ------AKMQCNQ-----MYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFFALRIIAYFV 823
                  .|:..|.     .||.|.|...||.:.:|.....|.: .....:|....|.|.||
Yeast  1313 FIDEFGGKLHINNTYTVCAYCMYTVGDDFLAQENMSYHHRWRN-FGFEWVFVCFNIAAMFV 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	178/747 (24%)
		ABCG_EPDR	142..366	CDD:213180	84/227 (37%)
		ABC2_membrane	564..767	CDD:279410	42/209 (20%)
PDR11	NP_012252.1	3a01205	56..1381	CDD:273362	198/841 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341533
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	2.930