DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and SNQ2

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_010294.1	Gene:	SNQ2 / 851574	SGDID:	S000002418	Length:	1501	Species:	Saccharomyces cerevisiae

Alignment Length:	740	Identity:	195/740 - (26%)
Similarity:	313/740 - (42%)	Gaps:	176/740 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 DISYSVTDSHRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINSK 213
            |:.:::  .:..|.:.:|.:|||....|.:||:||.|||||:||:|.||......::|.:|:|.:
Yeast   857 DVCFTI--PYEGGKRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGR 919

  Fly   214 ERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVN 278
            ..: ..|.:.:.|:.|.|:.||.|||||::..:|.::..:::....|:..||:|:..:|::|...
Yeast   920 PID-ASFERRTGYVQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAE 983

  Fly   279 TLT----CNLSGGQRKRLSIALELVNNPP-VMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVC 338
            .|.    |.|:..|||:|||.:|||..|. ::|.|||||||||.:.:.:|.|||.|::.|::|:|
Yeast   984 ALVGEVGCGLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILC 1048

  Fly   339 TIHQPSARLFEKFDHLYLLAQ-GQCVYEGRV----KGLVPYLSSLG-YECPSYHNPADYVLEVAS 397
            |||||||.|||:||.|.||.: ||.||.|.:    ..::.|....| .:|.|..|||:|:||..
Yeast  1049 TIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAI- 1112

  Fly   398 GEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLE 462
                                                        |:||..::        |....
Yeast  1113 --------------------------------------------GAGATASV--------KEDWH 1125

  Fly   463 DRQLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGP 527
            ::.|.              .:|.:|::..           |.|..:..|.:.|::.||..    |
Yeast  1126 EKWLN--------------SVEFEQTKEK-----------VQDLINDLSKQETKSEVGDK----P 1161

  Fly   528 SAVVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAI 592
            |...   ||.......|:       ..||  |.||    ||...|:...||        ::||.:
Yeast  1162 SKYA---TSYAYQFRYVL-------IRTS--TSFW----RSLNYIMSKMML--------MLVGGL 1202

  Fly   593 -IGMIYYDVGNEASKI-MSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVF-VREHLNYWYSLKAF 654
             ||..:::||.  |.: :.||....|:|:..:..||............:| |||..:..:.....
Yeast  1203 YIGFTFFNVGK--SYVGLQNAMFAAFISIILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLV 1265

  Fly   655 YFAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVL-ICVLNSLVAQSLGLLI------G 712
            ...:.::::|:.:.||:::.:..|:......|..|.:::.| .|::..|....|||:|      .
Yeast  1266 LITQYLSELPYHLFFSTIFFVSSYFPLRIFFEASRSAVYFLNYCIMFQLYYVGLGLMILYMSPNL 1330

  Fly   713 AGMNIETGV-------FLGPVTTIPTILFSGFFVNFDTIPGYLQWV------------------- 751
            ...|:..|:       |.|  .|.|..|..||:........|..:|
Yeast  1331 PSANVILGLCLSFMLSFCG--VTQPVSLMPGFWTFMWKASPYTYFVQNLVGIMLHKKPVVCKKKE 1393

  Fly   752 ----------TYVSYVRYGFEGAMVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDNALFWVD- 805
                      |...|::...|.|...|...| |...|  .||.|.|...:|..:|...:..|.:
Yeast  1394 LNYFNPPNGSTCGEYMKPFLEKATGYIENPD-ATSDC--AYCIYEVGDNYLTHISSKYSYLWRNF 1455

  Fly   806 AVALIGIFFALRIIAYFVLRWKLHM 830
            .:..|.|||  .|||...:.:..|:
Yeast  1456 GIFWIYIFF--NIIAMVCVYYLFHV 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	194/733 (26%)
		ABCG_EPDR	142..366	CDD:213180	92/222 (41%)
		ABC2_membrane	564..767	CDD:279410	50/248 (20%)
SNQ2	NP_010294.1	3a01205	103..1480	CDD:273362	195/740 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341523
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	4	3.840