DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abca6

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	846	Identity:	181/846 - (21%)
Similarity:	305/846 - (36%)	Gaps:	226/846 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 PQRP------PVDIEFCDISYSVTDSHR-RGFKTILKSVSGKFR----------NGEITAIMGPS 185
            |:.|      |||.|     |...::.| |..|...|..|||.:          ..:||||:|.|
Mouse   457 PELPSDEYFEPVDPE-----YQGKEAIRIRNIKKEYKGKSGKVKALKGLFLDIYESQITAILGHS 516

  Fly   186 GAGKSTLMNILAGYKTAQLSGSVLINSKE----RNLRRFRKLSCYIMQDDVLIANLTVREAMMVA 246
            |||||:|:|||:|. ....:|||.:.:|.    ::|:..||......|.:|....|||:|.:.:.
Mouse   517 GAGKSSLLNILSGL-YVPTAGSVTVYNKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTLF 580

  Fly   247 ANLKLGKNMISYAKVVVVEEILETIGLKESVNTLTCNLSGGQRKRLSIALELVNNPPVMFFDEPT 311
            |.:   |.::.......|::||..:.::...:.|..:||.||:::|:..:..|.:|.::..||||
Mouse   581 AKI---KGILPQDVEQEVQQILSELDMQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPT 642

  Fly   312 SGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQG--QC----VYEGRVKG 370
            .|||..:..::...|:........:..|.....|.:..  |...|:|.|  :|    |:..|..|
Mouse   643 VGLDPFSRQRIWGFLKERRADHVILFSTQFMDEADILA--DRKVLIANGALKCTGSSVFLKRKWG 705

  Fly   371 LVPYLSSLGYE-CPS--------YHNPADYV-LEVASGEYGDAVPKLVDAVKSGACKKYAHKDYV 425
            |..:||....| |.|        :|.|  |. |:..:.|      |||               |:
Mouse   706 LGYHLSLFMDETCDSERLTSFINHHIP--YAKLKAKTKE------KLV---------------YI 747

  Fly   426 LTLAQKG----CNNDIIKGSGSGA---ENAMA-----ILTLEDE---KPPLEDRQLEPSIPVDDP 475
            |.|.:..    ..:|:.|.||.|.   |.:|:     .|.||.|   |...|.|:........:.
Mouse   748 LPLERTSEFPEFFSDLDKYSGQGLMSYEVSMSTLNDVFLNLEGEPSTKQDFEKRETATDSESLND 812

  Fly   476 AELKPPKLETQQSQNSDCS--------------------------------------VVNMPTNA 502
            .|:..|.|...|...|..|                                      |:....||
Mouse   813 MEVAYPSLSQVQETVSTMSLWRMQVCAIARLRILKLKRERKAFLIILLLLGIALLPLVIEYVANA 877

  Fly   503 ---VDDSCSFSS-----SKGTQNAVGGSGSGGPSAVVGCMTSLLD---------------SHESV 544
               |.::..|.:     |.|             ....|..||||.               .|:::
Mouse   878 LLEVKNNWEFKTDLYFLSPG-------------QLPQGLRTSLLVINNTESNIEDFLQSLKHQNI 929

  Fly   545 V----TLPNKTGFPTSGWTQFWILLKRS----FRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVG 601
            |    ...|:....:..:....|:..|.    |..:...|.|....:..:||...|:.|:.:
Mouse   930 VLEVDDFENRNATNSLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFPILMNVISNGILHMLNH--- 991

  Fly   602 NEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFV----------REHLNYWYS---LKA 653
            .:..:|..:....|.|.::|........||.....:|..:          :.....|.|   ..|
Mouse   992 TQYIRIKEDIFSPFIVLVWTGIQETCLFILCVICSLSPHIAMSSVSDYKKKADSQLWISGLYPSA 1056

  Fly   654 FYFAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIGAGMNIE 718
            ::..:.:.|:.   :||.  :|:..|.||...:|..:.|      .:.:|...:.|.:|...::
Mouse  1057 YWCGQAVVDIS---LFSG--MLLTSYFTSYTSKLLNIDM------TSEIVFSVIVLALGCAASL- 1109

  Fly   719 TGVFLGPV-----------TTIPTILF-SGFFVNFDTIP-GYLQWVTYVSYV----RYGFEGAMV 766
              |||..|           :|:.:|.| ....:.|:.:. |.......:|..    .:...|.:|
Mouse  1110 --VFLTYVISFVFGKRKKNSTLWSICFLLVIAITFEKVANGPFNEALVISATMLVPSFALNGLLV 1172

  Fly   767 AIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFFALRIIAYFVLRWKLHMI 831
            .:      :|:..|.|..:...|..|.  ::|..|..:..:..:...|.||.:.   |::..:::
Mouse  1173 VL------EMRAYQYYIEFEEIKHGLS--AVDLLLCLIPYIHTLLFIFVLRCLE---LKYGKNVV 1226

  Fly   832 R 832
            |
Mouse  1227 R 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	179/837 (21%)
		ABCG_EPDR	142..366	CDD:213180	70/244 (29%)
		ABC2_membrane	564..767	CDD:279410	41/236 (17%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	181/846 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000