DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and abcg2a

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_021325521.1	Gene:	abcg2a / 735312	ZFINID:	ZDB-GENE-050517-35	Length:	644	Species:	Danio rerio

Alignment Length:	758	Identity:	201/758 - (26%)
Similarity:	348/758 - (45%)	Gaps:	162/758 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GGLGSNNHALAPKVANNSGGSPNGQKKGTIALSHLPQRPPVDIEFCDISYSVTDSHRRGF----- 162
            |.|...||.       |:|            :|..|.|....:.|.:|:||:  ..:.||
Zfish    10 GVLDLQNHV-------NTG------------VSSSPSRRGATVSFHNINYSL--KMKSGFCKSKS 53

  Fly   163 --KTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYK-TAQLSGSVLINSKERNLRRFRKLS 224
              |.||..::|..:.| :.||:|.:|:|||:.:::||..| .|.|||.|||:...:. ..|:.||
Zfish    54 TKKNILIGLNGIMKPG-LNAILGATGSGKSSFLDVLAARKDPAGLSGEVLIDGAPQP-PNFKCLS 116

  Fly   225 CYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNT-----LTCNL 284
            .|::||||::..|||||.:..:|.|:|.|::....|...||.:::.:||.:..::     |...:
Zfish   117 GYVVQDDVVMGTLTVRENLRFSAALRLPKSIKQREKDEKVERLIQELGLSKVADSRVGTQLIRGV 181

  Fly   285 SGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFE 349
            |||:|||.:|.:||:.:|||:|.||||:|||:||...::.||:.:...||||:.:||||...::.
Zfish   182 SGGERKRTNIGMELIIDPPVLFLDEPTTGLDASTANSVLMLLKKMGNNGRTIILSIHQPRYSIYR 246

  Fly   350 KFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVP--KLVDAVK 412
            .||.|.||..|:.||.|..:..:.|.|.:||.|..::||||:.|:|.:|: ..||.  ||.:.|
Zfish   247 LFDSLTLLVGGKLVYHGPAQDALSYFSQIGYTCEPHNNPADFFLDVINGD-SSAVTLNKLYEEV- 309

  Fly   413 SGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAE 477
                                .:.|.:..|..|                :|||.:|
Zfish   310 --------------------VDQDQLSSSLKG----------------IEDRLVE---------- 328

  Fly   478 LKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHE 542
                  |.|:|.      :...|:|           ..|..|.|                    :
Zfish   329 ------EYQRSS------IFQQTHA-----------DLQRIVQG--------------------Q 350

  Fly   543 SVVTLPNK--TGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEAS 605
            ...|.|..  ..:.||...||..:|||:||.::.:...:..::...:.:..::|.|::.|...:|
Zfish   351 DYSTRPKSRTITYSTSFCHQFHWVLKRTFRNLMLNPQTSVAQIGVMIFLALVVGAIFFGVAENSS 415

  Fly   606 KIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIAD-MPFQIVF 669
            .|.:..|.:||::....|:::....| |..|..:||.|:::.:|.:..::.:|.::| :..:.:.
Zfish   416 GIQNRMGALFFITTNQCFSSVSAAEL-FIAERKLFVHEYISGYYRVSVYFLSKILSDILTLRTIP 479

  Fly   670 SSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIGAGMNIE--TGVFLGPVTTIPTI 732
            :.::..|.|::.......|...:|:...::.|..|.::.|.|.|...:.  ..:|: .::.:..:
Zfish   480 AVIFSCVAYFMIGLKPAAEAFFIFLFSIIMVSYTATAMTLAISADQTVVAIANIFM-TISFVFMM 543

  Fly   733 LFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQ----MYCHYR------- 786
            :|||..||..::..:|.|:.|.|..|||.            :.:|.|:    .:|..|
Zfish   544 IFSGLLVNLPSVATWLNWLKYFSIPRYGL------------SALQINEFTGLFFCDNRNNSGSVC 596

  Fly   787 -VPKKFLEEMSMDNALF--WVDAVALIGIFFALRIIAYFVLRW 826
             ..::||:|..:|.:.:  |.:.:||..:.|....|||..||:
Zfish   597 SSGEEFLQEQGIDYSAWGLWQNHLALGIMTFIFLCIAYLKLRF 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	192/721 (27%)
		ABCG_EPDR	142..366	CDD:213180	91/236 (39%)
		ABC2_membrane	564..767	CDD:279410	45/205 (22%)
abcg2a	XP_021325521.1	PRK10535	43..638	CDD:333000	186/701 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740