DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg8

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_080456.1	Gene:	Abcg8 / 67470	MGIID:	1914720	Length:	673	Species:	Mus musculus

Alignment Length:	711	Identity:	167/711 - (23%)
Similarity:	299/711 - (42%)	Gaps:	161/711 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SYSVTDSHRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILA--GYKTAQLSGSVLINSK 213
            |:|..||...|    ::::|.|.|:|::.||:|.||.|:::|::::.  |:.....||.:.||.:
Mouse    78 SHSSQDSCELG----IRNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQ 138

  Fly   214 ERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVN 278
            ....:..||...::.|.|.|:.||||||.:...|.::|.:......:...||:::..:.|::..|
Mouse   139 PSTPQLVRKCVAHVRQHDQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAN 203

  Fly   279 TLTCN-----LSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVC 338
            |...|     :|||:|:|:||.::|:.||.::..|||||||||.|...|::.|..||:|.|.::.
Mouse   204 TRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLAKGNRLVLI 268

  Fly   339 TIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDA 403
            ::|||.:.:|..||.:.|:..|..:|.|..:.:|.|.:|:|:.||.|.||||:.:::.|
Mouse   269 SLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYVDLTS------ 327

  Fly   404 VPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEP 468
                :|.         ..|:..:...:|.              .::|.|.||..:
Mouse   328 ----IDR---------RSKEREVATVEKA--------------QSLAALFLEKVQ---------- 355

  Fly   469 SIPVDD---PAELKPPKLETQQ-----SQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSG 525
              ..||   .||.|.....|..     :|::||                    ||
Mouse   356 --GFDDFLWKAEAKELNTSTHTVSLTLTQDTDC--------------------GT---------- 388

  Fly   526 GPSAVVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRD--KMLTHMRLFSHVI 588
                              .|.||...       .||..|::|......||  .:|.|..  ...:
Mouse   389 ------------------AVELPGMI-------EQFSTLIRRQISNDFRDLPTLLIHGS--EACL 426

  Fly   589 VGAIIGMIYYDVGNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKA 653
            :..|||.:||..|.:....|..|..:|.:.....|..::..:....:|.|:...|..:..|:...
Mouse   427 MSLIIGFLYYGHGAKQLSFMDTAALLFMIGALIPFNVILDVVSKCHSERSMLYYELEDGLYTAGP 491

  Fly   654 FYFAKTIADMPFQIVFSSVYVLVVYYLTS-QPMELERVSMFVLICVLNSLV---AQSLGLLIGAG 714
            ::|||.:.::|....:..:|.:.:|:||: :|:.    .:|:|..:|..||   .:::.|...|
Mouse   492 YFFAKILGELPEHCAYVIIYAMPIYWLTNLRPVP----ELFLLHFLLVWLVVFCCRTMALAASA- 551

  Fly   715 MNIETGVFLGPVTTIPTI---------------LFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGA 764
                         .:||.               |.:||.:|.|.:.....|::.:|::|:.|.|.
Mouse   552 -------------MLPTFHMSSFFCNALYNSFYLTAGFMINLDNLWIVPAWISKLSFLRWCFSGL 603

  Fly   765 MVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFFALRIIAYFVLR 825
            |...:.......|... :....:....:..|.:::...:...:.:|||.:....:.|..|:
Mouse   604 MQIQFNGHLYTTQIGN-FTFSILGDTMISAMDLNSHPLYAIYLIVIGISYGFLFLYYLSLK 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	166/709 (23%)
		ABCG_EPDR	142..366	CDD:213180	75/221 (34%)
		ABC2_membrane	564..767	CDD:279410	49/223 (22%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	75/221 (34%)
		3a01204	89..664	CDD:273361	162/696 (23%)
		ABC2_membrane	402..606	CDD:279410	49/223 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640