Protein Alignment Atet and ABCG4

DIOPT Version :10

• Sequence 1: NP_523471.2
• Gene: Atet / 33636
• FlyBaseID: FBgn0020762
• Length: 832
• Species: Drosophila melanogaster
• Sequence 2: NP_071452.2
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 351/745 - (47%)
• Similarity: 460/745 - (61%)
• Gaps: 132/745 - (17%)

  Fly   104 GLGSNNHALAPKVANNSGGSP---------------NGQKKGTIALSHLPQRPPVDIEFCDISYS 153
            |.|....|:|..|....|..|               ..|:     .||||:|..|||||.::|||
Human    10 GCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQR-----FSHLPKRSAVDIEFVELSYS 69

  Fly   154 VTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINSKER 215
            |.:.   .:||:||:||.:||||...|:..|||||||||||.|||||||:.:.:.|.:|:|.:.|
Human    70 VREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134

  Fly   216 NLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNTL 280
            .||.|||:||||||||:|:.:|||.|||||:|||||.:.  ...|..:|.|||..:||....:|.
Human   135 ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTR 197

  Fly   281 TCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSA 345
            |..|||||||||:|||||||||||||||||||||||::|||::||::|||:|||||:||||||||
Human   198 TALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSA 262

  Fly   346 RLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDA 410
            :|||.||.||:|:||||:::|.|..|:|||..||..||:||||||:::|||||||||..|.|..|
Human   263 KLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRA 327

  Fly   411 VKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDP 475
            |::|.|                               |||    |.:..|.::....|..|.  |
Human   328 VQNGLC-------------------------------AMA----EKKSSPEKNEVPAPCPPC--P 355

  Fly   476 AELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDS 540
            .|:.|                                                         ::|
Human   356 PEVDP---------------------------------------------------------IES 363

  Fly   541 HESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEAS 605
            |.          |.||..|||.||.||:|.:||||.:|||:|..|||::|.:||::|..:|::||
Human   364 HT----------FATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDAS 418

  Fly   606 KIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFS 670
            |:.:|.||:||..||..|.|:|||:||||.||:||:||||||||||||:|.|||:||:|||:|..
Human   419 KVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483

  Fly   671 SVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIGAGMN-IETGVFLGPVTTIPTILF 734
            .||..:||::|.||.|..|..:|..:....:||||||||||||..| ::...|:||||.||.:||
Human   484 VVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLF 548

  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDN 799
            |||||:|.|||.||||.:|:|||||||||.::.||||:|..:.|.:..|.:|.|:..|..:.:::
Human   549 SGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVED 613

  Fly   800 ALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828
            |..::|.:.| |||| |||::||.|||:::
Human   614 AKLYMDFLVL-GIFFLALRLLAYLVLRYRV 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_523471.2	3a01204	137..825	CDD:273361	339/692 (49%)
ABCG4	NP_071452.2	3a01204	44..646	CDD:273361	344/711 (48%)