DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and abcg2c

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	749	Identity:	202/749 - (26%)
Similarity:	346/749 - (46%)	Gaps:	171/749 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 QKKGTIALSHLP--QRPPVDIEFCDISYSVTDSHRRGF-------KTILKSVSGKFRNGEITAIM 182
            ::..|.|...:|  |.|...:.|..|.|.:.:  |.|.       |.|||.||| ..|..:.|||
Zfish    15 EQSSTDADESVPCFQTPGPTVTFHQIRYRIKE--RLGMFSCQWREKDILKDVSG-IMNPGMNAIM 76

  Fly   183 GPSGAGKSTLMNILAGYKTAQ--LSGSVLINSK--ERNLRRFRKLSCYIMQDDVLIANLTVREAM 243
            ||:|:||::|::::||.|..:  .||.||:::.  ..:|   |..|.|::|:|:|:..|||||.:
Zfish    77 GPTGSGKTSLLDVIAGRKDPKGLKSGQVLVDNTIVTSDL---RLCSAYVVQNDILMGTLTVRENL 138

  Fly   244 MVAANLKLG-KNMISYAKVVVVEEILETIGLKESVNT-----LTCNLSGGQRKRLSIALELVNNP 302
            ..:|||:|. |...|..|.:.|..:::.:|||:..:|     ....:|||::||.||.:||:.:|
Zfish   139 AFSANLRLSLKEYSSSDKEMRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKRCSIGMELITSP 203

  Fly   303 PVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGR 367
            .::|.||||:|||::|...::.||:::::.|:|::.:||||...:|.:||||.|:.:|:.:|.|.
Zfish   204 SLLFLDEPTTGLDANTANSIMELLQNISKKGKTVIFSIHQPRYSIFRQFDHLTLMNKGEIIYAGA 268

  Fly   368 VKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKG 432
            ....:.|...|||:|..::||||:.|:|.:|                            |:....
Zfish   269 ADKAIIYFEDLGYKCEPFNNPADFFLDVTNG----------------------------TIRPHK 305

  Fly   433 CNNDIIKGSGSGA-----ENAMAILTLEDEKPP----LEDRQLEPSIPVDDPAELKPPKLETQQS 488
            .:|:|.:...|..     ||.:|::.   .|.|    |:||
Zfish   306 SSNNISEKCSSSEEMVDNENPLAVMY---RKSPYFTKLKDR------------------------ 343

  Fly   489 QNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTGF 553
                                                         :|.:.|..:..||..:|.|:
Zfish   344 ---------------------------------------------LTEISDGLDPEVTKGDKIGY 363

  Fly   554 PTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASKIMSN-AGCIFFV 617
            .|..:.|..::..|:.|.|||:...::.:||.::..|.::|:|||.:.:...:.:.| .|..||:
Zfish   364 ATPFYYQLLLVSGRTIRNILRNPQTSYAQLFLNIFFGILVGLIYYQIPHTLPEALQNRTGAFFFL 428

  Fly   618 SLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADM-PFQIVFSSVYVLVVYYLT 681
            .:...| ..:..:..|.:|..:|:.|:.:.:|...|::.:|..||: |.:|:...::..:.|::.
Zfish   429 VINMVF-GNLSAVELFVSERELFIHENSSGFYRTSAYFLSKVFADLIPNRILPVFIFSAIPYFMM 492

  Fly   682 SQPMELERVSMFVLICVLNSLV---AQSLGLLIGAGMNIETGVFLGPVTTIPTI---LFSGFFVN 740
            ....|:|   .|.|.||..|:|   |.||..|:.|  ::.:......:..:|.:   :|.||.||
Zfish   493 GLKPEVE---AFFLYCVTMSMVSLSAVSLAFLVSA--SVGSFAMANILIALPYVFMMVFGGFLVN 552

  Fly   741 FDTIPGYLQWVTYVSYVRYGFEGAMVAIYGM------DRAKMQCNQMYCHYRVPKKFLEEMSMDN 799
            .:::...|.|:.:.|..|||:..  :||..:      |........||         |:...:|.
Zfish   553 LNSMLSGLSWLKWASIFRYGYNA--LAINELKDQVFTDNLTRVTGDMY---------LDHQEIDR 606

  Fly   800 AL--FWVDAVALIGIFFALRIIAYFVL----RWK 827
            :.  ||.:.|||.||.|...|:||..|    |||
Zfish   607 SAWGFWENQVALAGIMFVCLILAYVQLCRINRWK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	197/735 (27%)
		ABCG_EPDR	142..366	CDD:213180	88/240 (37%)
		ABC2_membrane	564..767	CDD:279410	54/210 (26%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	88/238 (37%)
		3a01204	37..638	CDD:273361	194/723 (27%)
		ABC2_membrane	377..579	CDD:279410	55/209 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.710