DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and abcg4a

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_687685.2	Gene:	abcg4a / 564842	ZFINID:	ZDB-GENE-050517-39	Length:	641	Species:	Danio rerio

Alignment Length:	699	Identity:	339/699 - (48%)
Similarity:	455/699 - (65%)	Gaps:	111/699 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SHLPQRPPVDIEFCDISYSVTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNIL 196
            ||||:|..||:||.::||::.:.   .|||||.:||.:||||.:.|:..||||||||||||||||
Zfish    45 SHLPRRSTVDLEFTELSYTIREGPCWRRRGFKALLKCLSGKFCSRELIGIMGPSGAGKSTLMNIL 109

  Fly   197 AGYKTAQLSGSVLINSKERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKV 261
            |||:...:.|.:|:|.:.|:||.|||:||||||||:|:.:||.||||||:|||||.:||  ..|.
Zfish   110 AGYRETGMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTTREAMMVSANLKLNENM--EVKK 172

  Fly   262 VVVEEILETIGLKESVNTLTCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLL 326
            .:|.|||..:||:|...|.|.:|||||.|||:|||||||||||||||||||||||::|||::||:
Zfish   173 ELVNEILTALGLQECAQTRTISLSGGQCKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLM 237

  Fly   327 RSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADY 391
            :|||:|||||:||||||||:|||.||.||:|:||||:|:|.|..|:|||.:||..||:||||||:
Zfish   238 KSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIYKGTVPYLIPYLKNLGLHCPTYHNPADF 302

  Fly   392 VLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLED 456
            ::|||||||||..|.|.:||:.|.|.                                     :|
Zfish   303 IIEVASGEYGDLNPVLFEAVQGGLCS-------------------------------------DD 330

  Fly   457 EKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGG 521
            .|....|:                                |.||.:....|...|
Zfish   331 SKKNSSDK--------------------------------NDPTTSCPSQCYPDS---------- 353

  Fly   522 SGSGGPSAVVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSH 586
                          ..::.|.          |.||..|||.||.||:|.||.||.:|||:|:.||
Zfish   354 --------------GYIEKHT----------FATSTLTQFCILFKRTFITICRDVVLTHLRVMSH 394

  Fly   587 VIVGAIIGMIYYDVGNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSL 651
            :.:|.:||::|.::||:|||:.:|.|.:||..||..|.|:|||:||||.||.||:||||||||||
Zfish   395 LCIGVLIGLLYLNIGNDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLEMGVFIREHLNYWYSL 459

  Fly   652 KAFYFAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIG-AGM 715
            ||:|.|||:||:|||::...:|..:||::|.||.|..|..:|:.:....:||||||||||| |..
Zfish   460 KAYYLAKTMADIPFQVICPIMYCSIVYWMTEQPPEAGRYLLFMALSTSTALVAQSLGLLIGAAST 524

  Fly   716 NIETGVFLGPVTTIPTILFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQ 780
            :::...|:|||:.||.:|||||||||||||.||||.:|||||||||||.:::||||:|::::|..
Zfish   525 SLQVATFVGPVSAIPVLLFSGFFVNFDTIPKYLQWSSYVSYVRYGFEGVILSIYGMNRSELECPG 589

  Fly   781 MYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828
            :.|.::.|::.|:.:.:::|..:||.:.| |:|| .||:..|||||:|:
Zfish   590 IVCKFQKPEEVLQLLDVEDAKLYVDFMVL-GVFFLVLRLATYFVLRYKV 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	334/692 (48%)
		ABCG_EPDR	142..366	CDD:213180	145/226 (64%)
		ABC2_membrane	564..767	CDD:279410	118/203 (58%)
abcg4a	XP_687685.2	3a01204	38..641	CDD:273361	339/699 (48%)
		ABCG_EPDR	53..277	CDD:213180	145/225 (64%)
		ABC2_membrane	372..574	CDD:279410	118/201 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574359
Domainoid	1	1.000	274	1.000	Domainoid score	I1737
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75179
Inparanoid	1	1.050	699	1.000	Inparanoid score	I653
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm25175
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900