DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and abcg1

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_001103924.1	Gene:	abcg1 / 556979	ZFINID:	ZDB-GENE-070424-84	Length:	673	Species:	Danio rerio

Alignment Length:	767	Identity:	362/767 - (47%)
Similarity:	489/767 - (63%)	Gaps:	135/767 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LTNDLKQNSHG-------------SQNNLCNGGLGSNN----HALAPKVANNSGGSPNGQKKGTI 132
            :||.:..|::|             |.:.:.:..:.|..    ||...||.||   ....|:
Zfish    15 VTNSIIMNTNGPPDLMLDPRTVCVSIDEMMSNHVSSQQTPLLHAHLKKVENN---LTEAQR---- 72

  Fly   133 ALSHLPQRPPVDIEFCDISYSVTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMN 194
             .|:||:||.|:|||.|:||||.:.   .::|:||:||.:||.|..|.:.|||||||||||||||
Zfish    73 -FSYLPRRPAVNIEFKDLSYSVPEGPWWRKKGYKTLLKGISGNFTGGALVAIMGPSGAGKSTLMN 136

  Fly   195 ILAGYKTAQLSGSVLINSKERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYA 259
            |||||:...:.|.:|||...|:||.|||:||||||||:|:.:|||:|||||:|||||.:.  ...
Zfish   137 ILAGYRETGMKGEILINGHPRDLRSFRKVSCYIMQDDMLLPHLTVQEAMMVSANLKLQEK--DEG 199

  Fly   260 KVVVVEEILETIGLKESVNTLTCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLIS 324
            :..:|.|||..:||.|...|.|.:|||||||||:||||||||||||||||||||||||:|||::|
Zfish   200 RREMVREILTALGLLECAKTRTSHLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSSSCFQVVS 264

  Fly   325 LLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPA 389
            |:::||:||||::||||||||::||.||.||:|:||||:|.|:|..|:|||..||..||:|||||
Zfish   265 LMKALAQGGRTVICTIHQPSAKVFELFDKLYVLSQGQCIYRGKVSSLIPYLRDLGLSCPTYHNPA 329

  Fly   390 DYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTL 454
            |:::|||||||||...:||.||:...|:    |||...:            :|:|..|
Zfish   330 DFIMEVASGEYGDQTARLVKAVQEHKCE----KDYKTEM------------NGNGVHN------- 371

  Fly   455 EDEKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAV 519
                |.|..|      |.|:           :.|.:..|.             |||:|
Zfish   372 ----PFLWHR------PSDE-----------ESSSSEGCH-------------SFSAS------- 395

  Fly   520 GGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLF 584
                         |:                        |||.||.||:|.:|:||.:|||:|:.
Zfish   396 -------------CL------------------------TQFCILFKRTFLSIMRDSVLTHLRIM 423

  Fly   585 SHVIVGAIIGMIYYDVGNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWY 649
            ||:.:|.:||::|..:||||.|::||:|.:||..||..|.|:|||:||||.||.||:||||||||
Zfish   424 SHLGIGILIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWY 488

  Fly   650 SLKAFYFAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIG-A 713
            ||||:|.|||:||:||||||...|..:||::||||.:..|..:|:.:..|.|||||||||||| |
Zfish   489 SLKAYYLAKTMADVPFQIVFPVAYCSIVYWMTSQPSDAVRFILFLALGTLTSLVAQSLGLLIGAA 553

  Fly   714 GMNIETGVFLGPVTTIPTILFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQC 778
            ..:::...|:||||.||.:|||||||:|||||.||||::|:|||||||||.:::|||:||..:.|
Zfish   554 STSLQVATFVGPVTAIPVLLFSGFFVSFDTIPKYLQWISYISYVRYGFEGVILSIYGLDREDLHC 618

  Fly   779 NQ-MYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828
            :: ..||::..:..|:|:.:::|..::|.:.| |||| :||:|||||||:|:
Zfish   619 DKDETCHFQKSEAILKELDVEDAKLYMDFIVL-GIFFISLRLIAYFVLRYKI 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	345/693 (50%)
		ABCG_EPDR	142..366	CDD:213180	143/226 (63%)
		ABC2_membrane	564..767	CDD:279410	122/203 (60%)
abcg1	NP_001103924.1	3a01204	67..673	CDD:273361	350/712 (49%)
		ABCG_EPDR	81..306	CDD:213180	143/226 (63%)
		ABC2_membrane	403..605	CDD:279410	122/201 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574353
Domainoid	1	1.000	274	1.000	Domainoid score	I1737
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	699	1.000	Inparanoid score	I653
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm25175
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760